The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.
Open accessAbstract
A function of P in the alternative complement pathway is to prolong the first order decay of the hemolytic sites on EAC43B in a dose-dependent manner. As the number of initial convertase sites is not changed, even when activated properdin (P) increases the t1/2 10-fold or more, P acts to stabilize rather than to uncover additional sites. P binds to EAC43 to generate EAC43P in a reaction that proceeds slightly more rapidly at 15 degrees C than at 0 degrees C, but reaches the same plateau and does not require divalent cations. The presence of P on EAC43P not only stabilizes the convertase subsequently formed on that cell, but, alternatively, permits transfer to convertase sites on other cells with the stability of the recipient intermediate being dependent on the P available for transfer. The capacity of P to bind to C3b and stabilize C3B contrasts with the inhibitory effect of the C3b inactivator on formation of this amplification convertase.
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Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Pillemer, L., Blum, L., Lepow, I. H., Ross, O. A., Todd, E. W., & Wardlaw, A. C. (1954) · Science · doi:10.1126/science.120.3112.279 · Cited by 938
Nilsson, U. R., & Müller-Eberhard, H. J. (1965) · The Journal of Experimental Medicine · doi:10.1084/jem.122.2.277 · Cited by 412
C3 PROACTIVATOR CONVERTASE AND ITS MODE OF ACTION
Müller-Eberhard, H. J., & Götze, O. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.135.4.1003 · Cited by 324
Borsos, T., & Rapp, H. J. (1967) · The Journal of Immunology · doi:10.4049/jimmunol.99.2.263 · Cited by 220
Fearon, D. T., Austen, K. F., & Ruddy, S. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.138.6.1305 · Cited by 178
Self-citationPROPERDIN FACTOR D: CHARACTERIZATION OF ITS ACTIVE SITE AND ISOLATION OF THE PRECURSOR FORM
Fearon, D. T., Austen, K. F., & Ruddy, S. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.2.355 · Cited by 118
Self-citationInactivator of the Third Component of Complement as an Inhibitor in the Properdin Pathway
Alper, C. A., Rosen, F. S., & Lachmann, P. J. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.10.2910 · Cited by 103
Cited by
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
“and allowing de novo convertase assembly, and by stabilizing C3 convertase complexes (C3bBbP”
BackgroundComplement System Part I – Molecular Mechanisms of Activation and Regulation
Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00262 · Cited by 1,620
Molecular Biology and Chemistry of the Alternative Pathway of Complement
Müller-Eberhard, H. J., & Schreiber, R. D. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60042-5 · Cited by 408
Properdin: New roles in pattern recognition and target clearance
Kemper, C., & Hourcade, D. E. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.06.034 · Cited by 95
Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins
Shende, R., Wong, S. S. W., Rapole, S., Beau, R., Ibrahim-Granet, O., Monod, M., Gührs, K.-H., Pal, J. K., Latgé, J.-P., Madan, T., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001476 · Cited by 49
“We show that Mep1p blocks the alternative complement pathway (AP) by two different ways: 1) by generating C3b-like fragment in the fluid phase, facilitating its degradation by FH and FI; and 2) by cleaving properdin, which is a positive regulator of the AP C3-convertase (C3bBb) capable of stabilizing AP C3-convertase…”
Background
Metadata
- Authors
- Fearon, D. T., & Austen, K. F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1975-10-01
- Volume
- 142
- Issue
- 4
- Pages
- 856-863
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2014513484
- Cited by
- 481
- References
- 8
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fearon, D. T., & Austen, K. F. (1975). Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase. The Journal of experimental medicine. https://doi.org/10.1084/jem.142.4.856
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
