Properdin: New roles in pattern recognition and target clearance

Kemper, Claudia; Hourcade, Dennis E.

doi:10.1016/j.molimm.2008.06.034

Cited by 95Complement system in diseasesBiomarkers in Disease MechanismsCoagulation, Bradykinin, Polyphosphates, and Angioedema

Properdin: New roles in pattern recognition and target clearance

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Kemper, Claudia, Hourcade, Dennis E.·2008·Molecular Immunology

DOI 10.1016/j.molimm.2008.06.034PMC PMC2628304

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Abstract

Properdin was first described over 50 years ago by Louis Pillemer and his collaborators as a vital component of an antibody-independent complement activation pathway. In the 1970s properdin was shown to be a stabilizing component of the alternative pathway convertases, the central enzymes of the complement cascade. Recently we have reported that properdin can also bind to target cells and microbes, provide a platform for convertase assembly and function, and promote target phagocytosis. Evidence is emerging that suggests that properdin interacts with a network of target ligands, phagocyte receptors, and serum regulators. Here we review the new findings and their possible implications.

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Neutrophils store properdin, a critical positive regulator of the alternative pathway.
“not only store properdin (60), a critical positive regulator of the alternative pathway (61)”
From Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood (2022) · cites this paper as [61]

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Authors: Kemper, C., & Hourcade, D. E.
Affiliations: King's College London (GB)
Washington University in St. Louis (US)
Corresponding author: Hourcade, Dennis E.
ORCID: Kemper, Claudia
Hourcade, Dennis E.
Venue: Molecular Immunology
Publisher: Elsevier BV
Published: 2008-10
Volume: 45
Issue: 16
Pages: 4048-4056
ISSN: 0161-5890 (ISSN-L)
DOI: 10.1016/j.molimm.2008.06.034
PMC: PMC2628304
OpenAlex: W2067172213
Cited by: 95
References: 97
Citations by year: 2026: 3 · 2025: 1 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 7
FWCI: 0.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01 AI05143, R01AI051436)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Keywords: properdin, alternative complement pathway, pattern recognition, phagocytosis, target cell binding, antibody-independent complement activation
MeSH terms: Animals, Complement System Proteins, Complement Pathway, Alternative, Humans, Properdin, Models, Immunological

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Properdin: New roles in pattern recognition and target clearance

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