The DOI matches its Crossref record.
Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled.
Open accessAbstract
Virus-immune cytotoxic T cells can inhibit effectively growth of vaccinia virus in acutely infected target cells in vitro by destroying infected target cells before infectious virus progeny is assembled. Together with the fact that virus-specific T cells are demonstrable after 3 days, very early during infection, and with strong circumstantial evidence from adoptive transfer models in vivo, these data suggest that in some virus infections T cells may in fact act cytolytically in vivo to prevent virus growth and spread and be an important early antiviral effector mechanism.
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Citations
Cited by
Lymphocyte-Mediated Cytotoxicity
Russell, J. H., & Ley, T. J. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100201.131730 · Cited by 1,122
Duration of antiviral immunity after smallpox vaccination
Hammarlund, E., Lewis, M. W., Hansen, S. G., Strelow, L. I., Nelson, J. A., Sexton, G. J., Hanifin, J. M., & Slifka, M. K. (2003) · Nature Medicine · doi:10.1038/nm917 · Cited by 946
Alexander-Miller, M. A., Leggatt, G. R., & Berzofsky, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4102 · Cited by 501
Buller, R. M. L., & Palumbo, G. J. (1991) · Microbiological Reviews · doi:10.1128/mmbr.55.1.80-122.1991 · Cited by 452
Lukacher, A. E., Braciale, V. L., & Braciale, T. J. (1984) · The Journal of experimental medicine · doi:10.1084/jem.160.3.814 · Cited by 434
Metadata
- Authors
- Zinkernagel, R. M., & Althage, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1977-03-01
- Volume
- 145
- Issue
- 3
- Pages
- 644-651
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2131328157
- Cited by
- 159
- References
- 0
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Zinkernagel, R. M., & Althage, A. (1977). Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled. The Journal of experimental medicine. https://doi.org/10.1084/jem.145.3.644
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
