The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.
Open accessAbstract
Cloned lines of murine cytotoxic T lymphocytes (CTL) directed to type A influenza virus confer complete protection upon adoptive transfer to syngeneic mice lethally infected by influenza virus. The exquisite specificity exhibited by a subtype-specific cloned CTL in culture is reflected in its capacity to eliminate pulmonary virus and mediate recovery only in those mice infected by the virus subtype recognized by this cloned line in vitro. A cross-reactive CTL cloned line protects mice infected by either of two influenza virus subtypes. In mice dually infected with two virus subtypes, the subtype-specific CTL clone only reduces lung virus levels of the recognized virus subtype and cannot prevent these mice from dying. In contrast, adoptive transfer of the cross-reactive CTL clone into mice simultaneously infected with two virus subtypes results in reduction of pulmonary titers of both subtypes and promotes complete recovery. These results directly implicate CTL as an important antiviral defense mechanism in experimental influenza infection. In addition, these results indicate that both the induction and expression of antiviral effector activity by CTL in vivo is highly specific and therefore favor the concept that CTL express their antiviral effect in vivo by direct cytolysis of infected cells.
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Cites
Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus
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Cited by
Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones
Riddell, S. R., Watanabe, K. S., Goodrich, J. M., Li, C. R., Agha, M. E., & Greenberg, P. D. (1992) · Science · doi:10.1126/science.1352912 · Cited by 1,201
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection
Matloubian, M., Concepcion, R. J., & Ahmed, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8056-8063.1994 · Cited by 1,157
Induction of Protective CTL Responses in Newborn Mice by a Murine Retrovirus
Sarzotti, M., Robbins, D. S., & Hoffman, P. M. (1996) · Science · doi:10.1126/science.271.5256.1726 · Cited by 446
Effector CD4+ and CD8+ T‐cell mechanisms in the control of respiratory virus infections
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Reddehase, M. J., Weiland, F., Münch, K., Jonjic, S., Lüske, A., & Koszinowski, U. H. (1985) · Journal of Virology · doi:10.1128/jvi.55.2.264-273.1985 · Cited by 403
Metadata
- Authors
- Lukacher, A. E., Braciale, V. L., & Braciale, T. J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1984-09-01
- Volume
- 160
- Issue
- 3
- Pages
- 814-826
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2162336526
- Cited by
- 434
- References
- 15
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
