The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Suppression of in vitro cytotoxic response by macrophages due to induced arginase.
Open accessAbstract
Arginine was found to be completely depleted from cell-free supernates of mixed leukocyte cultures suppressed by the addition of excess macrophages. Partial reversal of macrophage-mediated suppression was accomplished by daily addition of a cocktail containing arginine and nonamino acid nutrients. Complete reversal of the suppression was accomplished by the addition of arginine and glucose to the medium and the nonadherent cells after their separation from the adherent macrophages. A marked increase in the enzyme arginase was found in macrophages that had been cultured 24 h in vitro in Eagle's minimum essential medium plus 10% fetal calf serum, in peritoneal cells activated by prior injection of thioglycollate, and in one spleen activated by a graft vs. host reaction.
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Citations
Cites
Amino acid metabolism in Mammalian cell cultures
Eagle, H. (1959) · Science · doi:10.1126/science.130.3373.432 · Cited by 4,011
Cited by
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Nitric oxide: A cytotoxic activated macrophage effector molecule
Hibbs, J. B., Taintor, R. R., Vavrin, Z., & Rachlin, E. M. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80015-9 · Cited by 2,030
Arginase: an emerging key player in the mammalian immune system
Munder, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00291.x · Cited by 694
L-arginine metabolism in myeloid cells controls T-lymphocyte functions
Bronte, V., Serafini, P., Mazzoni, A., Segal, D. M., & Zanovello, P. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00132-7 · Cited by 592
Metadata
- Authors
- Kung, J. T., Brooks, S. B., Jakway, J. P., Leonard, L. L., & Talmage, D. W.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1977-09-01
- Volume
- 146
- Issue
- 3
- Pages
- 665-672
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2146191721
- Cited by
- 188
- References
- 1
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kung, J. T., Brooks, S. B., Jakway, J. P., Leonard, L. L., & Talmage, D. W. (1977). Suppression of in vitro cytotoxic response by macrophages due to induced arginase. The Journal of experimental medicine. https://doi.org/10.1084/jem.146.3.665
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
