The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Arginase: an emerging key player in the mammalian immune system
Open accessAbstract
The enzyme arginase metabolizes L‐arginine to L‐ornithine and urea. Besides its fundamental role in the hepatic urea cycle, arginase is also expressed the immune system of mice and man. While significant interspecies differences exist regarding expression, subcellular localization and regulation of immune cell arginase, associated pathways of immunopathology are comparable between species. Arginase is induced in murine myeloid cells mainly by Th2 cytokines and inflammatory agents and participates in a variety of inflammatory diseases by down‐regulation of nitric oxide synthesis, induction of fibrosis and tissue regeneration. In humans, arginase I is constitutively expressed in polymorphonuclear neutrophils and is liberated during inflammation. Myeloid cell arginase‐mediated L‐arginine depletion profoundly suppresses T cell immune responses and this has emerged as a fundamental mechanism of inflammation‐associated immunosuppression. Pharmacological interference with L‐arginine metabolism is a novel promising strategy in the treatment of cancer, autoimmunity or unwanted immune deviation.
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Cites
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Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity
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Self-citationFunctional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
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Cited by
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
Rőszer, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/816460 · Cited by 1,762
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Arginase: A Multifaceted Enzyme Important in Health and Disease
Caldwell, R. W., Rodriguez, P. C., Toque, H. A., Narayanan, S. P., & Caldwell, R. B. (2018) · Physiological Reviews · doi:10.1152/physrev.00037.2016 · Cited by 495
Metadata
- Authors
- Munder, M.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2009-10
- Volume
- 158
- Issue
- 3
- Pages
- 638-651
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1581040284
- Cited by
- 694
- References
- 13
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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