The DOI matches its Crossref record.
C-reactive protein is protective against Streptococcus pneumoniae infection in mice.
Open accessAbstract
C-reactive protein (CRP) has several properties that suggest that it may function as a bacterial opsonin. CRP shows binding reactivity with pneumococcal C-polysaccharide, the cell wall carbohydrate of Streptococcus pneumoniae. In this study we have demonstrated protection of mice against serotypes 3 and 4 of S. pneumoniae infection by a single prior injection of CRP. This effect was seen both in mice that lacked antibody to phosphocholine and in normal mice. Thus the opsonic properties of CRP previously described may be related to protection against pneumococcal infection.
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Citations
Cited by
Black, S., Kushner, I., & Samols, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400025200 · Cited by 1,844
Function of C-reactive protein
Du Clos, T. W. (2000) · Annals of Medicine · doi:10.3109/07853890009011772 · Cited by 801
Self-citationGriselli, M., Herbert, J., Hutchinson, W. L., Taylor, K. M., Sohail, M., Krausz, T., & Pepys, M. B. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1733 · Cited by 508
The Induction of Meningeal Inflammation by Components of the Pneumococcal Cell Wall
Tuomanen, E., Liu, H., Hengstler, B., Zak, O., & Tomasz, A. (1985) · Journal of Infectious Diseases · doi:10.1093/infdis/151.5.859 · Cited by 355
Regulation of complement activation by C-reactive protein
Mold, C., Gewurz, H., & Du Clos, T. W. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00007-7 · Cited by 326
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Metadata
- Authors
- Mold, C., Nakayama, S., Holzer, T. J., Gewurz, H., & Du Clos, T. W.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1981-11-01
- Volume
- 154
- Issue
- 5
- Pages
- 1703-1708
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2035108061
- Cited by
- 244
- References
- 0
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Mold, C., Nakayama, S., Holzer, T. J., Gewurz, H., & Du Clos, T. W. (1981). C-reactive protein is protective against Streptococcus pneumoniae infection in mice. The Journal of experimental medicine. https://doi.org/10.1084/jem.154.5.1703
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
