The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis.
Open accessAbstract
We investigated the 1 alpha-hydroxylation of vitamin D3 sterols by cultured pulmonary alveolar macrophages (PAM) from patients with sarcoidosis with or without clinically abnormal calcium homeostasis. Like the naturally occurring renal 1 alpha-hydroxylase, the PAM 1 alpha-hydroxylation reaction exhibited a high affinity for 25-hydroxyvitamin D3 (25-OH-D3) and a preference for substrates containing a 25-hydroxyl group in the side chain of the sterol. Unlike the renal enzyme, the PAM 1 alpha-hydroxylating mechanism was not accompanied by 24-hydroxylating activity, even after preincubation with 75 nM 1,25-dihydroxyvitamin D3 [1,25-(OH)2-D3] or exposure to high concentrations of substrate (500 nM 25-OH-D3). The PAM 25-OH-D3-1 alpha-hydroxylation reaction was stimulated by gamma interferon and inhibited by exposure to the glucocorticoid dexamethasone. The characteristics of the PAM hydroxylation process in vitro appear to reflect the efficiency of the extrarenal production of 1,25-(OH)2-D3 and the therapeutic efficacy of glucocorticoids in patients with sarcoidosis and disordered calcium metabolism.
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Cites
Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis.
Adams, J. S., Sharma, O. P., Gacad, M. A., & Singer, F. R. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111147 · Cited by 545
Self-citation1,25-Dihydroxyvitamin D 3 : a Novel Immunoregulatory Hormone
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Crystal, R. G., Bitterman, P. B., Rennard, S. I., Hance, A. J., & Keogh, B. A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198401263100406 · Cited by 463
Regulation of the metabolism of vitamin D.
Fraser, D. R. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.2.551 · Cited by 347
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1, 25-DIHYDROXYCHOLECALCIFEROL IN THE PATHOGENESIS OF THE HYPERCALCÆMIA OF SARCOIDOSIS
Papapoulos, S. E., Fraher, L. J., Sandler, L. M., Clemens, T. L., Lewin, I. G., & O'Riordan, J. L. H. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91076-6 · Cited by 223
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Chapter 6 The Human Alveolar Macrophage
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Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Vitamin D metabolism, mechanism of action, and clinical applications
Bikle, D. D. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.12.016 · Cited by 1,933
Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator
Di Rosa, M., Malaguarnera, M., Nicoletti, F., & Malaguarnera, L. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03482.x · Cited by 447
The Clinical Features of Sarcoidosis: A Comprehensive Review
Judson, M. A. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-014-8450-y · Cited by 281
Vitamin D and the intracrinology of innate immunity
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Metadata
- Authors
- Adams, J. S., & Gacad, M. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1985-04-01
- Volume
- 161
- Issue
- 4
- Pages
- 755-765
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2080076458
- Cited by
- 323
- References
- 11
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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