Cited by 859Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNeurogenesis and neuroplasticity mechanisms

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Interleukin 1 of the central nervous system is produced by ameboid microglia.

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Giulian, D, Baker, T J, Shih, L C, Lachman, L B·1986·The Journal of experimental medicine

DOI 10.1084/jem.164.2.594PMC PMC2188228

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Abstract

By screening specific populations of rat brain cells, we found that ameboid microglia secrete an 18 kD peptide with IL-1 biological activity. The IL-1 activity released by microglia was found to be identical to rat macrophage IL-1 on fractionation by gel filtration and high pressure liquid anion-exchange chromatography, and it was neutralized by an antiserum specific for murine IL-1. When added to astroglia grown in culture, microglial IL-1 increased the cell number of five- to sevenfold, and increased astroglial incorporation of [3H]thymidine by three- to fivefold. We propose that the proliferation of astroglia in specific brain regions may be regulated by the signaled release of IL-1 from activated microglial cells.

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Self-citation
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Authors: Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B.
Venue: The Journal of experimental medicine
Publisher: Rockefeller University Press
Published: 1986-08-01
Volume: 164
Issue: 2
Pages: 594-604
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.164.2.594
PMC: PMC2188228
OpenAlex: W2159746265
Cited by: 859
References: 33
Citations by year: 2026: 3 · 2025: 8 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 10 · 2012: 14
FWCI: 21.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Eye Institute (EY04915)
National Cancer Institute (CA 38043)
National Institute of Neurological Disorders and Stroke (NS2311301)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: interleukin-1, ameboid microglia, microglial activation, astrocyte proliferation, neuroinflammation, rat brain
MeSH terms: Animals, Astrocytes, Brain, Cell Division, Cell Separation, Interleukin-1, Lymphocyte Activation, Nerve Growth Factors, Phagocytes, T-Lymphocytes, Rats

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Interleukin 1 of the central nervous system is produced by ameboid microglia.

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