Cited by 859Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNeurogenesis and neuroplasticity mechanisms

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Interleukin 1 of the central nervous system is produced by ameboid microglia.

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Giulian, D, Baker, T J, Shih, L C, Lachman, L B·1986·The Journal of experimental medicine

DOI 10.1084/jem.164.2.594PMC PMC2188228

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Abstract

By screening specific populations of rat brain cells, we found that ameboid microglia secrete an 18 kD peptide with IL-1 biological activity. The IL-1 activity released by microglia was found to be identical to rat macrophage IL-1 on fractionation by gel filtration and high pressure liquid anion-exchange chromatography, and it was neutralized by an antiserum specific for murine IL-1. When added to astroglia grown in culture, microglial IL-1 increased the cell number of five- to sevenfold, and increased astroglial incorporation of [3H]thymidine by three- to fivefold. We propose that the proliferation of astroglia in specific brain regions may be regulated by the signaled release of IL-1 from activated microglial cells.

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Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.
McCarthy, K. D., & de Vellis, J. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.85.3.890 · Cited by 3,825
Growth of a rat neuroblastoma cell line in serum-free supplemented medium.
Bottenstein, J. E., & SATO, G. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.514 · Cited by 2,268
Interleukin-1
Dinarello, C. A. (1984) · Clinical Infectious Diseases · doi:10.1093/clinids/6.1.51 · Cited by 1,647
Characterization of ameboid microglia isolated from developing mammalian brain
Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300
Self-citation
Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847
Self-citation
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
Lomedico, P. T., Gubler, U., Hellmann, C. P., Dukovich, M., Giri, J. G., Pan, Y. E., Collier, K. J., Semionow, R., Chua, A. O., & Mizel, S. B. (1984) · Nature · doi:10.1038/312458a0 · Cited by 816
Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture
RAFF, M. C., Fields, K. L., Hakomori, S., Mirsky, R., Pruss, R. M., & Winter, J. (1979) · Brain Research · doi:10.1016/0006-8993(79)90851-5 · Cited by 800
Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.
Fontana, A., Kristensen, F., Dubs, R., Gemsa, D., & Weber, E. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.6.2413 · Cited by 752
The functional relationship of the interleukins.
Smith, K. A., Lachman, L. B., Oppenheim, J. J., & Favata, M. F. (1980) · The Journal of Experimental Medicine · doi:10.1084/jem.151.6.1551 · Cited by 653
Self-citation
Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.
Dayer, J., Rochemonteix, B. G.-D., Burrus, B., Demczuk, S., & Dinarello, C. A. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112350 · Cited by 623

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Microglial and neural differentiation in human teratomas
Sangruchi, T., & Sobel, R. A. (1989) · Acta Neuropathologica · doi:10.1007/bf00687755 · Cited by 7
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Culture of neuronal cells from postnatal rat brain: Application to the study of neurotrophic factors
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de Freitas, R. M., Gomes, K. N., & Saldanha, G. B. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00838.x · Cited by 2
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Politis, M. J., & Lindsay, J. (1988) · Acta Neuropathologica · doi:10.1007/bf00687429 · Cited by 2
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Zhang, J., Gao, Y., Shen, Y., & Li, K. (2009) · PubMed · Cited by 2
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Lesnikov, V. A., Ефремов, О. М., Simbirtsev, A. S., Damme, J. V., & Billiau, A. (1994) · International Journal of Neuroscience · doi:10.3109/00207459408986037 · Cited by 1
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Baracchi, F., & Opp, M. R. (2008) · Springer eBooks · doi:10.1007/978-0-387-84851-8_11 · Cited by 1
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Ouassat, M. (1992) · doi:10.31274/rtd-180813-9690 · Cited by 1
Cell interactions in the CNS and their consequences for neuronal apoptosis
Berglund, M. (2005) · Figshare · Cited by 1
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Effects of zinc deficiency on immune functions
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Expression of interleukin-6 gene in human astrocyte cell lineages
Nitta, T., & Sato, K. (1994) · Journal of Clinical Neuroscience · doi:10.1016/0967-5868(94)90011-6 · Cited by 1
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Authors: Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B.
Venue: The Journal of experimental medicine
Publisher: Rockefeller University Press
Published: 1986-08-01
Volume: 164
Issue: 2
Pages: 594-604
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.164.2.594
PMC: PMC2188228
OpenAlex: W2159746265
Cited by: 859
References: 33
Citations by year: 2026: 3 · 2025: 8 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 10 · 2012: 14
FWCI: 21.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Eye Institute (EY04915)
National Cancer Institute (CA 38043)
National Institute of Neurological Disorders and Stroke (NS2311301)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: interleukin-1, ameboid microglia, microglial activation, astrocyte proliferation, neuroinflammation, rat brain
MeSH terms: Animals, Astrocytes, Brain, Cell Division, Cell Separation, Interleukin-1, Lymphocyte Activation, Nerve Growth Factors, Phagocytes, T-Lymphocytes, Rats

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Interleukin 1 of the central nervous system is produced by ameboid microglia.

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