The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Interleukin 1 of the central nervous system is produced by ameboid microglia.
Open accessAbstract
By screening specific populations of rat brain cells, we found that ameboid microglia secrete an 18 kD peptide with IL-1 biological activity. The IL-1 activity released by microglia was found to be identical to rat macrophage IL-1 on fractionation by gel filtration and high pressure liquid anion-exchange chromatography, and it was neutralized by an antiserum specific for murine IL-1. When added to astroglia grown in culture, microglial IL-1 increased the cell number of five- to sevenfold, and increased astroglial incorporation of [3H]thymidine by three- to fivefold. We propose that the proliferation of astroglia in specific brain regions may be regulated by the signaled release of IL-1 from activated microglial cells.
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“IL-1β is another prominent pro-inflammatory cytokine that is produced primarily by activated microglia and macrophages (Giulian et al., 1986; Sairanen et al., 1997).”
From Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned (2014) · cites this paper as Giulian et al., 1986
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“Furthermore, intraventricular administration of IL-1β was sufficient to induce lipid peroxidation in adult rats, highlighting the causal relationship between inflammatory signaling and metabolic stress, the two major characteristics of aging (Giulian et al, 1986).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Giulian et al, 1986
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Citations
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Metadata
- Authors
- Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-08-01
- Volume
- 164
- Issue
- 2
- Pages
- 594-604
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2188228
- OpenAlex
- W2159746265
- Cited by
- 859
- References
- 33
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 10 · 2012: 14
- FWCI
- 21.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY04915)
- National Cancer Institute (CA 38043)
- National Institute of Neurological Disorders and Stroke (NS2311301)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- interleukin-1, ameboid microglia, microglial activation, astrocyte proliferation, neuroinflammation, rat brain
- MeSH terms
- Animals, Astrocytes, Brain, Cell Division, Cell Separation, Interleukin-1, Lymphocyte Activation, Nerve Growth Factors, Phagocytes, T-Lymphocytes, Rats
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