The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.
Open accessAbstract
Growth and differentiation of thymocytes and mature T lymphocytes is regulated by cellular interactions that are in part mediated by soluble factors. We identify IL-6, formerly called B cell stimulating factor (BSF-2). IFN-beta 2, or hybridoma-plasmacytoma growth factor (HPGF) as a novel T cell costimulant rIL-6 induced a six-to seven-fold increase in proliferation of human thymocytes stimulated with suboptimal doses of PHA. A similar effect with added IL-6 could be observed using peripheral blood T lymphocytes, but only if the cultures were first rigorously depleted of monocytes that release high levels of IL-6. Analysis of the mechanism of the IL-6 effect on thymocytes and T lymphocytes showed that IL-6 did not lead to an increase in IL-2-R expression. Concentrations of antibody to IL-2-R inhibiting IL-2 effects did not block the IL-6-induced proliferation, indicating that the IL-6 effect was relatively IL-2 independent. These results identify IL-6 as a novel costimulant of human thymocytes and mature T lymphocytes, and suggest that IL-6 is also an important regulatory of cellular immunity.
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Cites
Gauldie, J., Richards, C., Harnish, D., Lansdorp, P., & Baumann, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7251 · Cited by 1,635
Kohase, M., Henriksen-DeStefano, D., May, L. T., Vilček, J., & Sehgal, P. B. (1986) · Cell · doi:10.1016/0092-8674(86)90780-4 · Cited by 567
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.
Yasukawa, K., Hirano, T., Watanabe, Y., Muratani, K., Matsuda, T., Nakai, S., & Kishimoto, T. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02598.x · Cited by 503
Self-citationHirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, A., Tsunasawa, S., & Sakiyama, F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.228 · Cited by 351
Self-citationGarman, R. D., Jacobs, K. A., Clark, S. C., & Raulet, D. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7629 · Cited by 349
Taga, T., Kawanishi, Y., Hardy, R. R., Hirano, T., & Kishimoto, T. (1987) · The Journal of experimental medicine · doi:10.1084/jem.166.4.967 · Cited by 310
Self-citationEarly Events In T-Cell Maturation
Adkins, B. (1987) · Annual Review of Immunology · doi:10.1146/annurev.immunol.5.1.325 · Cited by 240
Human β 2 Interferon and B-Cell Differentiation Factor BSF-2 Are Identical
Sehgal, P. B., May, L. T., Tamm, I., & Vilček, J. (1987) · Science · doi:10.1126/science.3492764 · Cited by 195
Activation of resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes.
Tsoukas, C. D., Landgraf, B. E., Bentin, J., Valentine, M. A., Lotz, M., Vaughan, J. H., & Carson, D. A. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.3.1719 · Cited by 128
Self-citationKishimoto, T. (1987) · Journal of Clinical Immunology · doi:10.1007/bf00917012 · Cited by 94
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Cited by
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Van Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768
Self-citationInterleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
Self-citationAge-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282
Metadata
- Authors
- Lotz, M., Jirik, F., Kabouridis, P., Tsoukas, C., Hirano, T., Kishimoto, T., & Carson, D. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-03-01
- Volume
- 167
- Issue
- 3
- Pages
- 1253-1258
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2022881613
- Cited by
- 527
- References
- 11
- FWCI
- 22.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lotz, M., Jirik, F., Kabouridis, P., Tsoukas, C., Hirano, T., Kishimoto, T., & Carson, D. A. (1988). B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. The Journal of experimental medicine. https://doi.org/10.1084/jem.167.3.1253
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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