The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus.
Open accessAbstract
In vitro infection by the human immunodeficiency virus (HIV) of CD4+ H9 lymphoblasts is inhibited by a mannose-binding protein (MBP) purified from human serum. In addition, MBP is able to selectively bind to HIV-infected H9 cells and HIV-infected cells from the monocyte cell line U937. These results indicate MBP most likely recognizes high mannose glycans known to be present on gp120 in the domain that is recognized by CD4 and thereby inhibits viral entry to susceptible cells. In support of this contention, recombinant gp120 binds directly to MBP; the binding is saturable, mannan inhibitable, removed by N-glycanase treatment, and dependent on divalent cations.
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Cites
Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D., & Gallo, R. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7415 · Cited by 5,043
Cited by
Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense
Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762
Neth, O., Jack, D. L., Dodds, A. W., Holzel, H., Klein, N. J., & Turner, M. W. (2000) · Infection and Immunity · doi:10.1128/iai.68.2.688-693.2000 · Cited by 561
Impact of Mannose-Binding Lectin on Susceptibility to Infectious Diseases
Eisen, D. P., & Minchinton, R. M. (2003) · Clinical Infectious Diseases · doi:10.1086/379324 · Cited by 435
The human mannose-binding protein functions as an opsonin.
Kuhlman, M., Joiner, K., & Ezekowitz, R. A. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.5.1733 · Cited by 434
Self-citationBashirova, A. A., Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Eilering, J. B. G., Martin, M. P., Wu, L., Martin, T. D., Viebig, N., Knolle, P. A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.671 · Cited by 358
Metadata
- Authors
- Ezekowitz, R. A., Kuhlman, M., Groopman, J. E., & Byrn, R. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-01-01
- Volume
- 169
- Issue
- 1
- Pages
- 185-196
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2136212260
- Cited by
- 333
- References
- 1
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ezekowitz, R. A., Kuhlman, M., Groopman, J. E., & Byrn, R. A. (1989). A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus. The Journal of experimental medicine. https://doi.org/10.1084/jem.169.1.185
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
