The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
Open accessAbstract
The discovery of dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3–grabbing nonintegrin (DC-SIGN) as a DC-specific ICAM-3 binding receptor that enhances HIV-1 infection of T cells in trans has indicated a potentially important role for adhesion molecules in AIDS pathogenesis. A related molecule called DC-SIGNR exhibits 77% amino acid sequence identity with DC-SIGN. The DC-SIGN and DC-SIGNR genes map within a 30-kb region on chromosome 19p13.2-3. Their strong homology and close physical location indicate a recent duplication of the original gene. Messenger RNA and protein expression patterns demonstrate that the DC-SIGN–related molecule is highly expressed on liver sinusoidal cells and in the lymph node but not on DCs, in contrast to DC-SIGN. Therefore, we suggest that a more appropriate name for the DC-SIGN–related molecule is L-SIGN, liver/lymph node–specific ICAM-3–grabbing nonintegrin. We show that in the liver, L-SIGN is expressed by sinusoidal endothelial cells. Functional studies indicate that L-SIGN behaves similarly to DC-SIGN in that it has a high affinity for ICAM-3, captures HIV-1 through gp120 binding, and enhances HIV-1 infection of T cells in trans. We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1.
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Cites
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Cited by
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
Tassaneetrithep, B., Burgess, T. H., Granelli-Piperno, A., Trumpfheller, C., Finke, J., Sun, W., Eller, M. A., Pattanapanyasat, K., Sarasombath, S., Birx, D. L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021840 · Cited by 890
C-type lectin receptors on dendritic cells and langerhans cells
Figdor, C. G., van Kooyk, Y., & Adema, G. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri723 · Cited by 842
Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR
Feinberg, H., Mitchell, D. A., Drickamer, K., & Weis, W. I. (2001) · Science · doi:10.1126/science.1066371 · Cited by 676
Pathology and Pathogenesis of Severe Acute Respiratory Syndrome
Gu, J., & Korteweg, C. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.061088 · Cited by 592
Living in the liver: hepatic infections
Protzer, U., Maini, M. K., & Knolle, P. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3169 · Cited by 560
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Metadata
- Authors
- Bashirova, A. A., Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Eilering, J. B. G., Martin, M. P., Wu, L., Martin, T. D., Viebig, N., Knolle, P. A., KewalRamani, V. N., van Kooyk, Y., & Carrington, M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-03-12
- Volume
- 193
- Issue
- 6
- Pages
- 671-678
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1995332691
- Cited by
- 358
- References
- 18
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection. https://app.cochat.ai/papers/10.1084/jem.193.6.671
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- Bashirova, A. A., Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Eilering, J. B. G., Martin, M. P., Wu, L., Martin, T. D., Viebig, N., Knolle, P. A., KewalRamani, V. N., van Kooyk, Y., & Carrington, M. (2001). A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.193.6.671
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
