The DOI matches its Crossref record.
Induction of classical transplantation tolerance in the adult.
Open accessAbstract
Transplantation tolerance across histoincompatibilities in multiple non-H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cells. Tolerance was associated with partial donor chimerism to various degrees. Tolerance to minor transplantation antigens induced in this manner was restricted to recipient-type MHC. The possibility was raised that tolerance resulted, at least in part, from clonal anergy rather than deletion.
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Citations
Cited by
"Infectious" Transplantation Tolerance
Qin, S., Cobbold, S. P., Pope, H., Elliott, J., Kioussis, D., Davies, J., & Waldmann, H. (1993) · Science · doi:10.1126/science.8094901 · Cited by 871
Self-citationClonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
Ramsdell, F., & Fowlkes, B. J. (1990) · Science · doi:10.1126/science.1972593 · Cited by 366
Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ
Sarvetnick, N., Shizuru, J., Liggitt, D., Martin, L., Mclntyre, B., Gregory, A., Parslow, T., & Stewart, T. (1990) · Nature · doi:10.1038/346844a0 · Cited by 335
A Nondeletional Mechanism of Thymic Self Tolerance
Ramsdell, F., Lantz, T., & Fowlkes, B. J. (1989) · Science · doi:10.1126/science.2511629 · Cited by 314
CD3-specific antibody-induced active tolerance: from bench to bedside
Chatenoud, L. (2003) · Nature Reviews Immunology · doi:10.1038/nri1000 · Cited by 309
Metadata
- Authors
- Qin, S. X., Cobbold, S., Benjamin, R., & Waldmann, H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-03-01
- Volume
- 169
- Issue
- 3
- Pages
- 779-794
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1990046941
- Cited by
- 317
- References
- 0
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Induction of classical transplantation tolerance in the adult. https://app.cochat.ai/papers/10.1084/jem.169.3.779
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- Qin, S. X., Cobbold, S., Benjamin, R., & Waldmann, H. (1989). Induction of classical transplantation tolerance in the adult. The Journal of experimental medicine. https://doi.org/10.1084/jem.169.3.779
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
