The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
A Nondeletional Mechanism of Thymic Self Tolerance
Abstract
T cells become tolerant of self antigens during their development in the thymus. Clonal deletion of thymocytes bearing self-reactive T cell receptors is a major mechanism for generating tolerance and occurs readily for antigens expressed by bone marrow-derived cells. Tolerance to antigens expressed on the radioresistant thymic stromal elements is demonstrated here to occur via a nondeletional mechanism. For minor lymphocyte stimulatory (Mls-1 a ) and major histocompatibility complex (MHC) antigens, this alternate form of tolerance induction results in clonal anergy.
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Citations
Cites
T cell tolerance by clonal elimination in the thymus
Kappler, J. W., Roehm, N., & Marrack, P. (1987) · Cell · doi:10.1016/0092-8674(87)90568-x · Cited by 2,211
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
Kisielow, P., Blüthmann, H., Staerz, U. D., Steinmetz, M., & von Boehmer, H. (1988) · Nature · doi:10.1038/333742a0 · Cited by 1,682
Kappler, J. W., Staerz, U., White, J., & Marrack, P. C. (1988) · Nature · doi:10.1038/332035a0 · Cited by 1,004
T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens
MacDonald, H. R., Schneider, R., Lees, R. K., Howe, R. C., Acha-Orbea, H., Festenstein, H., Zinkernagel, R. M., & Hengartner, H. (1988) · Nature · doi:10.1038/332040a0 · Cited by 888
Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.
Kubo, R. T., Born, W., Kappler, J. W., Marrack, P., & Pigeon, M. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.8.2736 · Cited by 747
Positive and negative selection of an antigen receptor on T cells in transgenic mice
Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russell, J. H., & Loh, D. Y. (1988) · Nature · doi:10.1038/336073a0 · Cited by 743
A monoclonal antibody discriminating between subsets of T and B cells.
Bruce, J., Symington, F. W., McKearn, T. J., & Sprent, J. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.6.2496 · Cited by 542
In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells
BEVAN, M. J. (1977) · Nature · doi:10.1038/269417a0 · Cited by 534
The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens
Pullen, A. M., Marrack, P., & Kappler, J. W. (1988) · Nature · doi:10.1038/335796a0 · Cited by 482
Rammensee, H.-G., Kroschewski, R., & Frangoulis, B. (1989) · Nature · doi:10.1038/339541a0 · Cited by 449
Cited by
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,820
A cell culture model for T lymphocyte clonal anergy
Schwartz, R. H. (1990) · Science · doi:10.1126/science.2113314 · Cited by 1,857
Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487
Liu, Y.-J., Soumelis, V., Watanabe, N., Ito, T., Wang, Y.-H., de Waal Malefyt, R., Omori, M., Zhou, B., & Ziegler, S. F. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141718 · Cited by 659
Evidence for the Effects of a Superantigen in Rheumatoid Arthritis
Paliard, X., West, S. G., Lafferty, J. A., Clements, J. R., Kappler, J. W., Marrack, P., & Kotzin, B. L. (1991) · Science · doi:10.1126/science.1857971 · Cited by 630
Metadata
- Authors
- Ramsdell, F., Lantz, T., & Fowlkes, B. J.
- Venue
- Science
- Published
- 1989-11-24
- Volume
- 246
- Issue
- 4933
- Pages
- 1038-1041
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016878829
- Cited by
- 314
- References
- 22
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
