The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation.
Open accessAbstract
Although previous studies using human cytokines in rabbits and rats have provided evidence of the participation of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) in the meningeal inflammatory cascade, the results obtained by several groups of investigators have been discordant or, at times, contradictory. In the present study, homologous cytokines were applied to the rabbit meningitis model. Intracisternal administration of 10(2)-10(5) IU of purified rabbit TNF-alpha (RaTNF-alpha) produced significant cerebrospinal fluid (CSF) inflammation. A similar response was observed after intracisternal inoculation of 5-200 ng of rabbit recombinant IL-1 beta (rrIL-1 beta). Preincubation of these two mediators with their specific antibodies resulted in an almost complete suppression of the CSF inflammatory response. In animals with Haemophilus influenzae type b lipooligosaccharide-induced meningitis, intracisternal administration of anti-rrIL-1 beta, anti-RaTNF-alpha, or both resulted in a significant modulation of meningeal inflammation. Simultaneous administration of 10(3) IU of RaTNF-alpha and 5 ng of rrIL-1 beta resulted in a synergistic inflammatory response manifested by a more rapid and significantly increased influx of white blood cells into the CSF compared with results after each cytokine given alone. These data provide evidence for a seminal role of TNF-alpha and IL-1 beta in the initial events of meningeal inflammation.
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Cites
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Cachectin: More Than a Tumor Necrosis Factor
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Cited by
Interleukin-1 and interleukin-1 antagonism
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Ziebell, J. M., & Morganti-Kossmann, M. C. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2009.10.016 · Cited by 667
Bacterial meningitis in children
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Metadata
- Authors
- Ramilo, O., Sáez-Llorens, X., Mertsola, J., Jafari, H., Olsen, K. D., Hansen, E. J., Yoshinaga, M., Ohkawara, S., Nariuchi, H., & McCracken, G. H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-08-01
- Volume
- 172
- Issue
- 2
- Pages
- 497-507
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2162456014
- Cited by
- 294
- References
- 28
- FWCI
- 20.45
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation. https://app.cochat.ai/papers/10.1084/jem.172.2.497
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- Ramilo, O., Sáez-Llorens, X., Mertsola, J., Jafari, H., Olsen, K. D., Hansen, E. J., Yoshinaga, M., Ohkawara, S., Nariuchi, H., & McCracken, G. H. (1990). Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation. The Journal of experimental medicine. https://doi.org/10.1084/jem.172.2.497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
