The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts.
Open accessAbstract
Conditioned media obtained from fibroblasts cultured from rheumatoid and certain other inflammatory synovia were observed to stimulate [3H]thymidine incorporation in an indicator murine fibroblast line. Synovial fibroblasts derived from the joints of patients with osteoarthritis did not display this property. This effect persisted in culture for many weeks and occurred in the absence of co-stimulatory immune cells. Antibody neutralization studies implicated a role for basic fibroblast growth factor (bFGF), transforming growth factor beta (TGF-beta), granulocyte/macrophage colony-stimulating factor (GM-CSF), and interleukin 1 beta (IL-1 beta) in the increased proliferative activity of synovial fibroblast-conditioned media. Synovial cell synthesis of bFGF, TGF beta 1, GM-CSF, IL-1 beta, and IL-6 was confirmed by 35S-methionine labeling and immunoprecipitation. The constitutive production of inflammatory and mitogenic cytokines by synovial fibroblasts may represent the result of long-term, phenotypic changes that occurred in vivo. Persistent cytokine production by synovial fibroblasts may play an important role in the continued recruitment and activation of inflammatory cells in chronic arthritis and in the formation of rheumatoid pannus.
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Folkman, J., & Klagsbrun, M. (1987) · Science · doi:10.1126/science.2432664 · Cited by 3,491
Transforming growth factor beta
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Self-citationNucleotide sequence of human monocyte interleukin 1 precursor cDNA.
Auron, P. E., Webb, A. C., Rosenwasser, L. J., Mucci, S. F., Rich, A., Wolff, S. M., & Dinarello, C. A. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.24.7907 · Cited by 1,042
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Interleukin 1, a potential regulator of fibroblast proliferation.
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Isolation and structure of urogastrone and its relationship to epidermal growth factor
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Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization
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Cited by
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
Bucala, R., Spiegel, L. A., Chesney, J., Hogan, M., & Cerami, A. (1994) · Molecular Medicine · doi:10.1007/bf03403533 · Cited by 1,308
Self-citationCancer associated fibroblasts (CAFs) in tumor microenvironment
Xing, F. (2010) · Frontiers in Bioscience · doi:10.2741/3613 · Cited by 682
Crofford, L. J., Wilder, R. L., Ristimäki, A. P., Sano, H., Remmers, E. F., Epps, H. R., & Hla, T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117060 · Cited by 655
Firestein, G. S. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780391103 · Cited by 591
Ben-Av, P., Crofford, L. J., Wilder, R. L., & Hla, T. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00956-a · Cited by 566
Metadata
- Authors
- Bucala, R., Ritchlin, C., Winchester, R., & Cerami, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-03-01
- Volume
- 173
- Issue
- 3
- Pages
- 569-574
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2065018137
- Cited by
- 261
- References
- 23
- FWCI
- 14.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bucala, R., Ritchlin, C., Winchester, R., & Cerami, A. (1991). Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts. The Journal of experimental medicine. https://doi.org/10.1084/jem.173.3.569
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
