Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer.
Open accessAbstract
We report here the role of the CXC chemokine, epithelial neutrophil activating peptide (ENA-78), as an angiogenic factor in human non-small cell lung cancer (NSCLC). In freshly isolated human specimens of NSCLC, elevated levels of ENA-78 were found that strongly correlated with the vascularity of the tumors. In a SCID mouse model of human NSCLC tumorigenesis, expression of ENA-78 in developing tumors correlated with tumor growth in two different NSCLC cell lines. Furthermore, passive immunization of NSCLC tumor-bearing mice with neutralizing anti-ENA-78 antibodies reduced tumor growth, tumor vascularity, and spontaneous metastases, while having no effect on the proliferation of NSCLC cells either in vitro or in vivo. These findings suggest that ENA-78 is an important angiogenic factor in human NSCLC.
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In mouse models, ENA-78/CXCL5 variably affects tumour growth, vascularity and apoptosis.
“in mouse models, ENA-78/CXCL5 variably affects tumour growth, vascularity and apoptosis46.”
From Inflammation and cancer (2002) · cites this paper as [46]
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- Authors
- Arenberg, D. A., Keane, M. P., DiGiovine, B., Kunkel, S. L., Morris, S. B., Xue, Y. Y., Burdick, M. D., Glass, M. C., Iannettoni, M. D., & Strieter, R. M.
- Affiliations
- University of Michigan (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1998-08-01
- Volume
- 102
- Issue
- 3
- Pages
- 465-472
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508906
- OpenAlex
- W2051810280
- Cited by
- 259
- References
- 32
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 14 · 2014: 11 · 2013: 10 · 2012: 9
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- National Institutes of Health (1r01ca066180-01a1, 5k08ca072543-05, 5r01hl050057-05, CA66180, HL35276, CA72543)
- National Heart, Lung, and Blood Institute (HL50057)
- National Cancer Institute (CA66180, CA72543)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- CXCL5, CXC chemokines, angiogenesis, non-small cell lung cancer, tumor vascularity, tumor growth, metastasis, neutralizing antibodies, SCID mouse xenograft
- MeSH terms
- Adenocarcinoma, Animals, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Cell Division, Female, Humans, Immunization, Passive, Lung Neoplasms, Neoplasm Proteins, Neoplasm Transplantation, Neovascularization, Pathologic, Tumor Cells, Cultured, Interleukin-8, Mice, SCID, Apoptosis, Chemokines, CXC, Mice, Rats, Chemokine CXCL5
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