The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.
Open accessAbstract
Hematopoietic stem cells (HSCs) are defined in mice by three activities: they must rescue lethally irradiated mice (radioprotection), they must self-renew, and they must restore all blood cell lineages permanently. We initially demonstrated that HSCs were contained in a rare (approximately 0.05%) subset of bone marrow cells with the following surface marker profile: Thy-1.1lo Lin- Sca-1+. These cells were capable of long-term, multi-lineage reconstitution and radioprotection of lethally irradiated mice with an enrichment that mirrors their representation in bone marrow, namely, 1,000-2,000-fold. However, the experiments reported did not exclude the possibility that stem cell activity may also reside in populations that are Thy-1.1-, Sca-1-, or Lin+. In this article stem cell activity was determined by measuring: (a) radioprotection provided by sorted cells; (b) long-term, multi-lineage reconstitution of these surviving mice; and (c) long-term, multi-lineage reconstitution by donor cells when radioprotection is provided by coinjection of congenic host bone marrow cells. Here we demonstrate that HSC activity was detected in Thy-1.1+, Sca-1+, and Lin- fractions, but not Thy-1.1-, Sca-1-, or Lin+ bone marrow cells. We conclude that Thy-1.1lo Lin- Sca-1+ cells comprise the only adult C57BL/Ka-Thy-1.1 mouse bone marrow subset that contains pluripotent HSCs.
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Cites
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Cited by
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
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Self-citationIdentification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
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Self-citationA role for Wnt signalling in self-renewal of haematopoietic stem cells
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Self-citationGeneration of a functional mammary gland from a single stem cell
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Metadata
- Authors
- Uchida, N., & Weissman, I. L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1992-01-01
- Volume
- 175
- Issue
- 1
- Pages
- 175-184
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2154992787
- Cited by
- 359
- References
- 19
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. https://app.cochat.ai/papers/10.1084/jem.175.1.175
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- Uchida, N., & Weissman, I. L. (1992). Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. The Journal of experimental medicine. https://doi.org/10.1084/jem.175.1.175
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