The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Contribution of Receptor Editing to the Antibody Repertoire
Abstract
Receptor editing, clonal deletion, and anergy are the mechanisms by which B cells maintain tolerance to self antigens. To determine the extent to which receptor editing shapes the normal antibody repertoire, we generated an immunoglobulin κ polymorphism that facilitates the detection of editing of immunoglobulin light chains in vivo. We found that B cells are targeted for editing during a 2-hour delay in development at the pre-BII cell stage, and that about 25% of all antibody molecules are produced by gene replacement. These results suggest that receptor editing represents a major force in shaping the antibody repertoire.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The clonal selection theory of acquired immunity
Burnet, F. M. (1959) · Vanderbilt University Press eBooks · doi:10.5962/bhl.title.8281 · Cited by 2,619
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,601
Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T. B., Smith-Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., et al. (1988) · Nature · doi:10.1038/334676a0 · Cited by 1,565
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
Nemazee, D. A., & Bürki, K. (1989) · Nature · doi:10.1038/337562a0 · Cited by 1,016
Self-citationReceptor editing: an approach by autoreactive B cells to escape tolerance.
Gay, D., Saunders, T., Camper, S., & Weigert, M. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.4.999 · Cited by 920
Receptor editing in self-reactive bone marrow B cells.
Tiegs, S. L., Russell, D. M., & Nemazee, D. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.4.1009 · Cited by 766
Self-citationHartley, S. B., Cooke, M. P., Fulcher, D. A., Harris, A. W., Cory, S., Basten, A., & Goodnow, C. C. (1993) · Cell · doi:10.1016/0092-8674(93)90111-3 · Cited by 509
Allman, D. M., Ferguson, S. E., Lentz, V. M., & Cancro, M. P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.4431 · Cited by 408
Grawunder, U., Leu, T. M. J., Schatz, D. G., Werner, A., Rolink, A. G., Melchers, F., & Winkler, T. H. (1995) · Immunity · doi:10.1016/1074-7613(95)90131-0 · Cited by 378
Coleclough, C., Perry, R. P., Karjalainen, K., & Weigert, M. (1981) · Nature · doi:10.1038/290372a0 · Cited by 308
Cited by
Positive and negative selection of T cells
Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141107 · Cited by 1,601
Phospholipase Cγ2 Contributes to Light-Chain Gene Activation and Receptor Editing
Bai, L., Chen, Y., He, Y., Dai, X., Lin, X., Wen, R., & Wang, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02273-06 · Cited by 22
Metadata
- Authors
- Casellas, R., Shih, T.-A. Y., Kleinewietfeld, M., Rakonjac, J., Nemazee, D., Rajewsky, K., & Nussenzweig, M. C.
- Venue
- Science
- Published
- 2001-02-23
- Volume
- 291
- Issue
- 5508
- Pages
- 1541-1544
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060489436
- Cited by
- 313
- References
- 29
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Contribution of Receptor Editing to the Antibody Repertoire. https://app.cochat.ai/papers/10.1126/science.1056600
- The paper
- Casellas, R., Shih, T.-A. Y., Kleinewietfeld, M., Rakonjac, J., Nemazee, D., Rajewsky, K., & Nussenzweig, M. C. (2001). Contribution of Receptor Editing to the Antibody Repertoire. Science. https://doi.org/10.1126/science.1056600
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
