The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Impaired interleukin 12 production in human immunodeficiency virus-infected patients.
Open accessAbstract
Peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-infected patients, asymptomatic or with acquired immunodeficiency virus, produced 10-fold less interleukin 12 (IL-12) free heavy chain and fivefold less biologically active IL-12 heterodimer than PBMC from uninfected healthy donors when challenged in vitro with the common human pathogen Staphylococcus aureus. In contrast, PBMC from HIV-infected individuals and uninfected control donors produced similar levels of tumor necrosis factor alpha, IL-1 beta, and IL-10, and PBMC from HIV-infected individuals produced three- to fourfold more IL-6 compared with PBMC from uninfected control donors. The defect in IL-12 production is not due to hyperproduction of IL-10, a cytokine exerting an autocrine-negative feedback on IL-12 production, but was directly related to HIV infection, as suggested by the reduced ability of monocytes infected in vitro with HIV to produce IL-12. IL-12 deficiency may be an important component of the immunodeficiency associated with HIV infection.
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Self-citationA TH1→TH2 switch is a critical step in the etiology of HIV infection
Clerici, M., & Shearer, G. M. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90208-3 · Cited by 1,390
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Self-citationD'Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi, J., Kubin, M., Aste, M., Chan, S. H., Kobayashi, M., Young, D., & Nickbarg, E. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.5.1387 · Cited by 1,144
Self-citationInterleukin-12 and its role in the generation of TH1 cells
Trinchieri, G. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90230-i · Cited by 845
Self-citationPathogenesis of human immunodeficiency virus infection
Levy, J. A. (1993) · Microbiological Reviews · doi:10.1128/mr.57.1.183-289.1993 · Cited by 839
Gazzinelli, R. T., Hieny, S., Wynn, T. A., Wolf, S., & Sher, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6115 · Cited by 835
Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy
Fauci, A. S. (1993) · Science · doi:10.1126/science.8235617 · Cited by 776
Recombinant interleukin 12 cures mice infected with Leishmania major.
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Cited by
Functional diversity of helper T lymphocytes
Abbas, A. K., Murphy, K. M., & Sher, A. (1996) · Nature · doi:10.1038/383787a0 · Cited by 4,450
Interleukin-18 Regulates Both Th1 and Th2 Responses
Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,315
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
Trinchieri, G. (1998) · Advances in Immunology · doi:10.1016/s0065-2776(08)60387-9 · Cited by 760
Self-citationThe Th1–Th2 hypothesis of HIV infection: new insights
Clerici, M., & Shearer, G. M. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90220-8 · Cited by 685
Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.
van der Pouw Kraan, T. C., Boeije, L. C., Smeenk, R. J., Wijdenes, J., & Aarden, L. A. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.2.775 · Cited by 666
Metadata
- Authors
- Chehimi, J., Starr, S. E., Frank, I., D'Andrea, A., Ma, X., MacGregor, R. R., Sennelier, J., & Trinchieri, G.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-04-01
- Volume
- 179
- Issue
- 4
- Pages
- 1361-1366
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2154916884
- Cited by
- 419
- References
- 21
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chehimi, J., Starr, S. E., Frank, I., D'Andrea, A., Ma, X., MacGregor, R. R., Sennelier, J., & Trinchieri, G. (1994). Impaired interleukin 12 production in human immunodeficiency virus-infected patients. The Journal of experimental medicine. https://doi.org/10.1084/jem.179.4.1361
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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