The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.
Open accessAbstract
During human immunodeficiency virus infection and allergic diseases, characterized by a dominant T helper (Th) 2 response, overproduction of prostaglandin E2 (PGE2) is observed. In this paper we studied the effect of PGE2 on interleukin (IL)-12 synthesis, because this cytokine has been described to be essential in induction of Th1 responses. IL-12 synthesis was induced in monocytes that were stimulated with Neisseria meningitidis-derived lipopolysaccharide in whole blood cultures. PGE2 almost completely inhibited lipopolysaccharide induced IL-12 production, whereas IL-6 production was only partially inhibited by PGE2. In contrast, the production of IL-10 was approximately twofold enhanced at these conditions. The effects of PGE2 were due to its cAMP-inducing capacity, since they could be mimicked by other cAMP inducers. Recombinant human IL-10 also inhibited IL-12 and IL-6 production. However, the inhibitory effect of PGE2 on IL-12 production was independent of IL-10 since neutralizing anti-IL-10 antibodies were unable to reverse this inhibition. These results suggest that the capacity of an antigen to induce PGE2 synthesis may play a crucial role in the development of either a Th1 or Th2 response.
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Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
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Self-citationHuman TH1 and TH2 subsets: doubt no more
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Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252
IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS
Wills-Karp, M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.255 · Cited by 1,020
Type 1/Type 2 Immunity in Infectious Diseases
Spellberg, B., & Edwards, J. E. (2001) · Clinical Infectious Diseases · doi:10.1086/317537 · Cited by 911
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Metadata
- Authors
- van der Pouw Kraan, T. C., Boeije, L. C., Smeenk, R. J., Wijdenes, J., & Aarden, L. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-02-01
- Volume
- 181
- Issue
- 2
- Pages
- 775-779
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2126043069
- Cited by
- 666
- References
- 28
- FWCI
- 33.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van der Pouw Kraan, T. C., Boeije, L. C., Smeenk, R. J., Wijdenes, J., & Aarden, L. A. (1995). Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. The Journal of experimental medicine. https://doi.org/10.1084/jem.181.2.775
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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