The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy
Abstract
The immunopathogenic mechanisms underlying human immunodeficiency virus (HIV) disease are extremely complex; the disease process is multifactorial with multiple overlapping phases. Viral burden is substantial and viral replication occurs throughout the entire course of HIV infection. Inappropriate immune activation and elevated secretion of certain cytokines compound the pathogenic process. Profound immunosuppression ultimately occurs together with a disruption of the microenvironment of the immune system, which is probably unable to regenerate spontaneously. Thus, therapeutic strategies in HIV disease must not be unidimensional, but rather must be linked to the complex pathogenic components of the disease and must address where feasible each of the recognized pathogenic processes for the possibility of therapeutic intervention.
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Citations
Cites
Poli, G., Kinter, A., Justement, J. S., Kehrl, J. H., Bressler, P., Stanley, S., & Fauci, A. S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.782 · Cited by 457
Self-citation
Cited by
Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein
Li, C. J., Friedman, D. J., Wang, C., Metelev, V., & Pardee, A. B. (1995) · Science · doi:10.1126/science.7716549 · Cited by 580
Induction of HIV-1 Replication in Latently Infected CD4+ T Cells Using a Combination of Cytokines
Chun, T.-W., Engel, D., Mizell, S. B., Ehler, L. A., & Fauci, A. S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.83 · Cited by 359
Self-citationHIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells
Oswald-Richter, K., Grill, S. M., Shariat, N., Leelawong, M., Sundrud, M. S., Haas, D. W., & Unutmaz, D. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020198 · Cited by 301
Pantaleo, G., Cohen, O. J., Schacker, T., Vaccarezza, M., Graziosi, C., Rizzardi, G. P., Kahn, J., Fox, C. H., Schnittman, S. M., Schwartz, D. H., et al. (1998) · Nature Medicine · doi:10.1038/nm0398-341 · Cited by 132
Self-citationRücker, E., Grivel, J.-C., Münch, J., Kirchhoff, F., & Margolis, L. (2004) · Journal of Virology · doi:10.1128/jvi.78.22.12689-12693.2004 · Cited by 48
Metadata
- Authors
- Fauci, A. S.
- Venue
- Science
- Published
- 1993-11-12
- Volume
- 262
- Issue
- 5136
- Pages
- 1011-1018
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970622835
- Cited by
- 776
- References
- 1
- FWCI
- 32.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fauci, A. S. (1993). Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy. Science. https://doi.org/10.1126/science.8235617
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
