The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.
Open accessAbstract
We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased quantities of IL-8 were detected in tumor tissue as compared with normal lung tissue. Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. Functional studies that used tissue homogenates of tumors demonstrated the induction of both in vitro endothelial cell chemotaxis and in vivo corneal neovascularization. It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific attenuation of these responses. Our observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies.
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Cites
Interleukin-8 as a macrophage-derived mediator of angiogenesis
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Self-citationNeutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.
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Self-citationInduction of angiogenesis during the transition from hyperplasia to neoplasia
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Self-citationEndothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β
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Self-citationBazzoni, F., Cassatella, M. A., Rossi, F., Ceska, M., Dewald, B., & Baggiolini, M. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.3.771 · Cited by 436
Relation of vascular proliferation to tumor growth.
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Cited by
Gerard, C., & Rollins, B. J. (2001) · Nature Immunology · doi:10.1038/84209 · Cited by 1,357
The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis
Strieter, R. M., Polverini, P. J., Kunkel, S. L., Arenberg, D. A., Burdick, M. D., Kasper, J., Dzuiba, J., Van Damme, J., Walz, A., Marriott, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27348 · Cited by 1,222
Self-citationRas-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, A., & Bar-Sagi, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.028 · Cited by 851
Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects
Battegay, E. J. (1995) · Journal of Molecular Medicine · doi:10.1007/bf00192885 · Cited by 537
Phillips, R. J., Burdick, M. D., Lutz, M., Belperio, J. A., Keane, M. P., & Strieter, R. M. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200301-071oc · Cited by 455
Self-citation
Metadata
- Authors
- Smith, D. R., Polverini, P. J., Kunkel, S. L., Orringer, M. B., Whyte, R. I., Burdick, M. D., Wilke, C. A., & Strieter, R. M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-05-01
- Volume
- 179
- Issue
- 5
- Pages
- 1409-1415
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2145921423
- Cited by
- 373
- References
- 25
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. https://app.cochat.ai/papers/10.1084/jem.179.5.1409
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- Smith, D. R., Polverini, P. J., Kunkel, S. L., Orringer, M. B., Whyte, R. I., Burdick, M. D., Wilke, C. A., & Strieter, R. M. (1994). Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. The Journal of experimental medicine. https://doi.org/10.1084/jem.179.5.1409
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
