The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Fas ligand mediates activation-induced cell death in human T lymphocytes.
Open accessAbstract
A significant proportion of previously activated human T cells undergo apoptosis when triggered through the CD3/T cell receptor complex, a process termed activation-induced cell death (AICD). Ligation of Fas on activated T cells by either Fas antibodies or recombinant human Fas-ligand (Fas-L) also results in cytolysis. We demonstrate that these two pathways of apoptosis are causally related. Stimulation of previously activated T cells resulted in the expression of Fas-L mRNA and lysis of Fas-positive target cells. Fas-L antagonists inhibited AICD of T cell clones and staphylococcus enterotoxin B (SEB)-specific T cell lines. The data indicate AICD in previously stimulated T cells is mediated by Fas/Fas-L interactions.
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Cites
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Cited by
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Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Self-citationTumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
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The many roles of FAS receptor signaling in the immune system
Strasser, A., Jost, P. J., & Nagata, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.001 · Cited by 968
Metadata
- Authors
- Alderson, M. R., Tough, T. W., Davis-Smith, T., Braddy, S., Falk, B., Schooley, K. A., Goodwin, R. G., Smith, C. A., Ramsdell, F., & Lynch, D. H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-01-01
- Volume
- 181
- Issue
- 1
- Pages
- 71-77
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2129971278
- Cited by
- 934
- References
- 36
- FWCI
- 29.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Alderson, M. R., Tough, T. W., Davis-Smith, T., Braddy, S., Falk, B., Schooley, K. A., Goodwin, R. G., Smith, C. A., Ramsdell, F., & Lynch, D. H. (1995). Fas ligand mediates activation-induced cell death in human T lymphocytes. The Journal of experimental medicine. https://doi.org/10.1084/jem.181.1.71
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