The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.
Open accessAbstract
Commitment of T helper 1 (Th1) or Th2 populations developing during an immune response to a pathogen, or an inappropriate immune response to an allergen or autoantigen, may determine the difference between health and chronic disease. We show that strongly polarized Th1 and Th2 populations assessed by immunoassay are heterogeneous using flow cytometry to detect single cells producing interferon gamma (IFN-gamma) and interleukin 4 (IL-4). Th1 populations arising after 1 wk of stimulation in IL-12 plus anti-IL-4 antibodies could convert to Th2 cells when restimulated in IL-4. Th2 populations resulting from stimulation for 1 wk in IL-4 could give rise to Th1 cells upon restimulation in IL-12 plus anti-IL-4. In contrast, the cytokine profiles of long-term Th1 and Th2 populations arising originally from repeated stimulation in IL-12 or IL-4 appeared more homogeneous and were not reversible, although IL-4 dramatically reduced the number of IFN-gamma-producing Th1 cells. This may explain previous reports that Th1 cells can be converted to Th2 cells.
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Cites
Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G., & Lepper, H. (1995) · Nature · doi:10.1038/373255a0 · Cited by 662
Cited by
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Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Plasticity of CD4+ T Cell Lineage Differentiation
Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551
Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., & Stockinger, B. (2008) · Nature Immunology · doi:10.1038/ni.1659 · Cited by 1,213
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
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Microbial lipopeptides induce the production of IL-17 in Th cells
Infante-Duarte, C., Horton, H. F., Byrne, M. C., & Kamradt, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6107 · Cited by 586
Effector T cell plasticity: flexibility in the face of changing circumstances
Murphy, K. M., & Stockinger, B. (2010) · Nature Immunology · doi:10.1038/ni.1899 · Cited by 482
Self-citationLee, H. J., Takemoto, N., Kurata, H., Kamogawa, Y., Miyatake, S., O'Garra, A., & Arai, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.1.105 · Cited by 393
Self-citationCutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells
Zingoni, A., Soto, H., Hedrick, J. A., Stoppacciaro, A., Storlazzi, C. T., Sinigaglia, F., D’Ambrosio, D., O’Garra, A., Robinson, D., Rocchi, M., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.2.547 · Cited by 357
Self-citationRepositioning TH cell polarization from single cytokines to complex help
Tuzlak, S., Dejean, A. S., Iannacone, M., Quintana, F. J., Waisman, A., Ginhoux, F., Korn, T., & Becher, B. (2021) · Nature Immunology · doi:10.1038/s41590-021-01009-w · Cited by 171
IFN Regulatory Factor 4 Regulates the Expression of a Subset of Th2 Cytokines
Ahyi, A.-N. N., Chang, H.-C., Dent, A. L., Nutt, S. L., & Kaplan, M. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803302 · Cited by 137
Gamper, C. J., Agoston, A. T., Nelson, W. G., & Powell, J. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802960 · Cited by 100
De Novo DNA Methylation Is Required to Restrict T Helper Lineage Plasticity
Thomas, R. M., Gamper, C. J., Ladle, B. H., Powell, J. D., & Wells, A. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.312785 · Cited by 79
Overexpression of the transcription factor GATA-3 enhances the development of pulmonary fibrosis
Kimura, T., Ishii, Y., Yoh, K., Morishima, Y., Iizuka, T., Kiwamoto, T., Matsuno, Y., Homma, S., Nomura, A., Sakamoto, T., et al. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051160 · Cited by 55
Th2 Cells: Orchestrating Barrier Immunity
(2004) · Advances in Immunology · doi:10.1016/s0065-2776(04)83005-0 · Cited by 44
Metadata
- Authors
- Murphy, E., Shibuya, K., Hosken, N., Openshaw, P., Maino, V, Davis, K., Murphy, K., & O'Garra, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-03-01
- Volume
- 183
- Issue
- 3
- Pages
- 901-913
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2099918076
- Cited by
- 435
- References
- 1
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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