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Absence of Respiratory Burst in X-linked Chronic Granulomatous Disease Mice Leads to Abnormalities in Both Host Defense and Inflammatory Response to Aspergillus fumigatus
Open accessAbstract
Mice with X-linked chronic granulomatous disease (CGD) generated by targeted disruption of the gp91phox subunit of the NADPH-oxidase complex (X-CGD mice) were examined for their response to respiratory challenge with Aspergillus fumigatus. This opportunistic fungal pathogen causes infection in CGD patients due to the deficient generation of neutrophil respiratory burst oxidants important for damaging A. fumigatus hyphae. Alveolar macrophages from X-CGD mice were found to kill A. fumigatus conidia in vitro as effectively as alveolar macrophages from wild-type mice. Pulmonary disease in X-CGD mice was observed after administration of doses ranging from 10(5) to 48 spores, none of which produced disease in wild-type mice. Higher doses produced a rapidly fatal bronchopneumonia in X-CGD mice, whereas progression of disease was slower at lower doses, with development of chronic inflammatory lesions. Marked differences were also observed in the response of X-CGD mice to the administration of sterilized Aspergillus hyphae into the lung. Within 24 hours of administration, X-CGD mice had significantly higher numbers of alveolar neutrophils and increased expression of the proinflammatory cytokines IL-1 beta and TNF-alpha relative to the responses seen in wild-type mice. By one week after administration, pulmonary inflammation was resolving in wild-type mice, whereas X-CGD mice developed chronic granulomatous lesions that persisted for at least six weeks. This is the first experimental evidence that chronic inflammation in CGD does not always result from persistent infection, and suggests that the clinical manifestations of this disorder reflect both impaired microbial killing as well as other abnormalities in the inflammatory response in the absence of a respiratory burst.
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“Although killing of Aspergillus conidia by AMs is undoubtedly dependent on both oxidative and nonoxidative mechanisms (240, 241)”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [240]
In the citing paper
“much of the discrepancy in the literature is related to differences in study endpoints (e.g., inhibition of growth versus killing), methodology of killing assessment (e.g., CFU plating versus conidial germination), moiety of infection, infection time points, NADPH oxidase knockout mouse strains, and method of immunosuppression used (203, 240–245).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [240]
In the citing paper
“Unlike the neutropenic mouse model, extensive signs of chronic inflammation remained evident in the X-CGD mice post-day 14, consistent with previously reported results in these animals [45].”
From A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus (2008) · cites this paper as [45]
In the citing paper
“These mice exhibit a hyper-inflammatory response when exposed to A. fumigatus and other Aspergillus species.”
From A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus (2008) · cites this paper as [45]
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Citations
Cites
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,793
Tissue Destruction by Neutrophils
(1989) · New England Journal of Medicine · doi:10.1056/nejm198908033210513 · Cited by 3,634
Staal, F. J. T., Roederer, M., Herzenberg, L. A., & Herzenberg, L. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9943 · Cited by 956
Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics · doi:10.1038/ng0295-202 · Cited by 921
Self-citationHuman monocyte chemoattractant protein-1 (MCP-1)
Leonard, E. J., & Yoshimura, T. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90035-8 · Cited by 662
Schaffner, A., Douglas, H., & Braude, A. I. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110489 · Cited by 618
Yoshimura, T., Yuhki, N., Moore, S. K., Appella, E., Lerman, M. I., & Leonard, E. J. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80590-3 · Cited by 589
The p47phox mouse knock-out model of chronic granulomatous disease.
Jackson, S. H., Gallin, J. I., & Holland, S. M. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.751 · Cited by 484
The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH
Segal, A. W., Geisow, M. J., Garcia, R. C., Harper, A., & Miller, R. F. (1981) · Nature · doi:10.1038/290406a0 · Cited by 422
Doerschuk, C. M., Winn, R. K., Coxson, H. O., & Harlan, J. M. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.6.2327 · Cited by 408
Self-citationRegulation of interleukin 8 gene expression by oxidant stress.
DeForge, L. E., Preston, A. M., Takeuchi, E., Kenney, J., Boxer, L. A., & Remick, D. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74429-9 · Cited by 389
Chemokine binding and activities mediated by the mouse IL-8 receptor
Lee, J., Cacalano, G., Camerato, T. R., Toy, K. J., Moore, M. W., & Wood, W. I. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.4.2158 · Cited by 348
Expression and biologic characterization of the murine chemokine KC.
Bozic, C. R., Kolakowski, L. F., Gerard, N. P., Garcia-Rodriguez, C., von Uexkull-Guldenband, C., Conklyn, M. J., Breslow, R., Showell, H. J., & Gerard, C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.11.6048 · Cited by 294
Human monocytes/macrophages: NO or no NO?
Denis, M. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.5.682 · Cited by 274
Ulich, T. R., Yin, S., Guo, K., Yi, E. S., Remick, D. G., & del Castillo, J. M. G. (1991) · PubMed Central · Cited by 241
Recent Advances in Chronic Granulomatous Disease
Gallin, J. I., BUESCHER, E. S., SELIGMANN, B. E., NATH, J., GAITHER, T., & KATZ, P. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-5-657 · Cited by 232
Mouse neutrophils lack defensins
Eisenhauer, P. B., & Lehrer, R. (1992) · Infection and Immunity · doi:10.1128/iai.60.8.3446-3447.1992 · Cited by 227
Schaffner, A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112166 · Cited by 206
Diamond, R. D., KRZESICKI, R. F., Epstein, B., & Jao, W. (1978) · PubMed Central · Cited by 205
Diamond, R. D., & Clark, R. A. (1982) · Infection and Immunity · doi:10.1128/iai.38.2.487-495.1982 · Cited by 192
Endemic and Epidemic Aspergillosis Associated with In-Hospital Replication of Aspergillus Organisms
Arnow, P. M., Sadigh, M., Costas, C., Weil, D., & Chudy, R. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/164.5.998 · Cited by 163
THIRTEEN BOYS WITH PROGRESSIVE SEPTIC GRANULOMATOSIS
Carson, M. J., Chadwick, D. L., Brubaker, C. A., Cleland, R. S., & Landing, B. H. (1965) · PEDIATRICS · doi:10.1542/peds.35.3.405 · Cited by 147
Chemotactic Factor Inactivation by the Myeloperoxidase-Hydrogen Peroxide-Halide System
Clark, R. A., & Klebanoff, S. J. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109557 · Cited by 139
Endogenous Reactive Oxygen Intermediates Activate Tyrosine Kinases in Human Neutrophils
Brumell, J. H., Burkhardt, A. L., Bolen, J. B., & Grinstein, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1455 · Cited by 138
The Respiratory Burst Oxidase and the Molecular Genetics of Chronic Granulomatous Disease
Dinauer, M. C., & Newburger, P. E. (1993) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369309082591 · Cited by 130
Self-citationThe NADPH oxidase and chronic granulomatous disease
Segal, A. W. (1996) · Molecular Medicine Today · doi:10.1016/1357-4310(96)88723-5 · Cited by 130
Killing of Aspergillus spores depends on the anatomical source of the macrophage
Schaffner, A., Douglas, H., Braude, A. I., & Davis, C. E. L. B. (1983) · Infection and Immunity · doi:10.1128/iai.42.3.1109-1115.1983 · Cited by 128
Lehmann, P. F., & White, L. O. (1975) · Infection and Immunity · doi:10.1128/iai.12.5.987-992.1975 · Cited by 125
Protecting Effect of Chitin and Chitosan on Experimentally Induced Murine Candidiasis
Suzuki, K., Okawa, Y., Hashimoto, K., Suzuki, S., & Suzuki, M. (1984) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1984.tb00746.x · Cited by 112
Fungus dose-dependent primary pulmonary aspergillosis in immunosuppressed mice
Dixon, D. M., Polak, A., & Walsh, T. J. (1989) · Infection and Immunity · doi:10.1128/iai.57.5.1452-1456.1989 · Cited by 107
Boros, D. L. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000401230 · Cited by 106
Washburn, R. G., Gallin, J. I., & Bennett, J. E. (1987) · Infection and Immunity · doi:10.1128/iai.55.9.2088-2092.1987 · Cited by 98
Mechanisms of Destruction of Aspergillus fumigatus Hyphae Mediated by Human Monocytes
Diamond, R. D., Huber, E., & Haudenschild, C. C. (1983) · The Journal of Infectious Diseases · doi:10.1093/infdis/147.3.474 · Cited by 87
Chronic Familial Granulomatosis
Johnston, R. B. (1967) · American journal of diseases of children · doi:10.1001/archpedi.1967.02090250068002 · Cited by 86
Chemotactic factor inactivation by myeloperoxidase-mediated oxidation of methionine.
Clark, R. A., Szot, S., Venkatasubramanian, K., & Schiffmann, E. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.4.2020 · Cited by 79
Interaction of Aspergillus fumigatus Spores with Human Leukocytes and Serum
Lehrer, R. I., & Jan, R. G. (1970) · Infection and Immunity · doi:10.1128/iai.1.4.345-350.1970 · Cited by 68
Gallin, J. I., & Buescher, E. S. (1983) · Inflammation · doi:10.1007/bf00917259 · Cited by 62
Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase.
Kubo, H., Morgenstern, D. E., Quinian, W. M., Ward, P. A., Dinauer, M. C., & Doerschuk, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118718 · Cited by 60
Self-citationResistance of spores of Aspergillus fumigatus to ingestion by phagocytic cells.
Robertson, M. D., Seaton, A., Milne, L. J. R., & Raeburn, J. A. (1987) · Thorax · doi:10.1136/thx.42.6.466 · Cited by 59
Surgical Pathology of the Lung in Chronic Granulomatous Disease
Moskaluk, C. A., Pogrebniak, H. W., Pass, H. I., Gallin, J. I., & Travis, W. D. (1994) · American Journal of Clinical Pathology · doi:10.1093/ajcp/102.5.684 · Cited by 52
Chemical components of the cell wall of Aspergillus species
Ruíz-Herrera, J. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90130-0 · Cited by 50
EXPERIMENTAL PULMONARY ASPERGILLOSIS.
Sidransky, H., Verney, E., & Beede, H. (1965) · PubMed · Cited by 43
In Vitro Tumoricidal Activity of Resting and Glucan-Activated Kupffer Cells
Sherwood, E. R., Williams, D. L., McNamee, R. B., Jones, E. L., Browder, I. W., & Luzio, N. R. D. (1987) · Journal of Leukocyte Biology · doi:10.1002/jlb.42.1.69 · Cited by 42
Corticosteroids for chronic granulomatous disease
Quie, P. G., & Belani, K. (1987) · The Journal of Pediatrics · doi:10.1016/s0022-3476(87)80460-2 · Cited by 31
Environmental Aerobiological Studies in Allergic Bronchopulmonary Aspergillosis
Beaumont, F., Kauffman, H. F., Sluiter, H., & de Vries, K. (1984) · Allergy · doi:10.1111/j.1398-9995.1984.tb02623.x · Cited by 25
Wilkes, D. S., Heidler, K. M., Bowen, L. K., Quinlan, W. M., Doyle, N. A., Cummings, O. W., & Doerschuk, C. M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.5.2775 · Cited by 21
Self-citation[Chronic familial granulomatosis].
Bastin, R., Vildé, J., Renou, P., Vilde, F., & Zribi, A. (1970) · PubMed · Cited by 14
Experi-mental Pulmonary Aspergillosis
Sawasaki, H., Horie, K., NAITO, Y., Watabe, S., Tajima, G., Mizutani, Y., & Jo, K. (1960) · Japanese Journal of Medical Mycology · doi:10.3314/jjmm1960.1.3_258 · Cited by 5
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2 of the 51 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Pollock, 1995, Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocytes superoxide production, Nat Genet, 9, 202, 10.1038/ng0295-202 · DOI · Paper page
Cited by
Sorted by citations
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Aspergillus fumigatus and Aspergillosis
Latgé, J.-P. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.2.310 · Cited by 2,307
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
Metadata
- Authors
- Morgenstern, D. E., Gifford, M. A. C., Li, L. L., Doerschuk, C. M., & Dinauer, M. C.
- Affiliations
- Riley Hospital for Children (US)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-01-20
- Volume
- 185
- Issue
- 2
- Pages
- 207-218
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2196125
- OpenAlex
- W2138396364
- Cited by
- 370
- References
- 51
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 13 · 2020: 7 · 2019: 11 · 2018: 11 · 2017: 18 · 2016: 12 · 2015: 11 · 2014: 22 · 2013: 18 · 2012: 17
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by-nc-sa)
- UNC Libraries
- Funders
- Arthritis Foundation
- National Institutes of Health (5r01hl052565-05)
- National Heart, Lung, and Blood Institute (R01 HL52565)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- X-linked chronic granulomatous disease, Aspergillus fumigatus, respiratory burst, NADPH oxidase, gp91phox, alveolar macrophages, neutrophils, lung inflammation, IL-1β, TNF-α, fungal infection, bronchopneumonia
- MeSH terms
- NADPH Oxidase 2, Animals, Aspergillus fumigatus, Granulomatous Disease, Chronic, Inflammation, Genetic Linkage, Lung Diseases, Membrane Glycoproteins, Phagocytosis, X Chromosome, Cytokines, Macrophages, Alveolar, Respiratory Burst, NADPH Oxidases, Mice
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