Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

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1. Interleukin-18 attracts plasmacytoid dendritic cells (DC2s) and promotes Th1 induction by DC2s through IL-18 receptor expression
   Arthur Kaser, Susanne Kaser, Nicole C. Kaneider, Barbara Enrich, Christian Josef Wiedermann, Herbert Tilg · 2003 · Blood
2. Cytokines regulating osteoclast formation and function
   Sun‐Kyeong Lee, Joseph Lorenzo · 2006 · Current Opinion in Rheumatology
3. Roles of IFN Consensus Sequence Binding Protein and PU.1 in Regulating IL-18 Gene Expression
   Yong-Man Kim, Hyung-Sik Kang, Sang‐Gi Paik, Kwang-Ho Pyun, Karen L. Anderson, Bruce Edward Torbett, Inpyo Choi · 1999 · The Journal of Immunology
4. Interleukin (Il)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13
   Helena Helmby, Kiyoshi Takeda, Shizuo Akira, Richard K. Grencis · 2001 · The Journal of Experimental Medicine
5. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction
   Claire Greenhill, Gareth W Jones, Mari A. Nowell, Zarabeth Newton, Ann K Harvey, Abdul Nazeer Moideen, Fraser L. Collins, Anja C. Bloom, Rebecca C. Coll, Avril A. B. Robertson et al. · 2014 · Arthritis Research & Therapy
6. Osteoblast Responses to Bacterial Pathogens: A Previously Unappreciated Role for Bone-Forming Cells in Host Defense and Disease Progression
   Ian Marriott · 2004 · Immunologic Research
7. Depletion of CD4 and CD8 T Lymphocytes in Mice In Vivo Enhances 1,25-Dihydroxyvitamin D3-Stimulated Osteoclast-Like Cell Formation In Vitro by a Mechanism That Is Dependent on Prostaglandin Synthesis
   Danka Grčević, Sun‐Kyeong Lee, Ana Marušić, Joseph Lorenzo · 2000 · The Journal of Immunology
8. IL-18 Enhances Collagen-Induced Arthritis by Recruiting Neutrophils Via TNF-α and Leukotriene B4
   Claudio A. Cannetti, Bernard P. L. Leung, Shauna Culshaw, Iain B. McInnes, Fernando Q. Cunha, Foo Yew Liew · 2003 · The Journal of Immunology
9. Zinc Finger Protein 467 Is a Novel Regulator of Osteoblast and Adipocyte Commitment
   Julie Quach, Emma C. Walker, Elizabeth H. Allan, Melissa Solano, Atsushi Yokoyama, Shigeaki Kato, Natalie A. Sims, Matthew T. Gillespie, Thomas John Martin · 2010 · Journal of Biological Chemistry
10. Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines
    K-E Kim, Hanjung Song, Tae Soo Kim, Do‐Young Yoon, C-w Kim, Sa Ik Bang, Dae Young Hur, Hyun Park, D-H Cho · 2006 · Oncogene
11. Adenoviral delivery of IL-18 binding protein C ameliorates Collagen-Induced Arthritis in mice
    Ruben L. Smeets, Fons A. J. van de Loo, Onno J. Arntz, Miranda B Bennink, Leo A. B. Joosten, Wim B. van den Berg · 2003 · Gene Therapy
12. The effect of macrophage-colony stimulating factor and other humoral factors (interleukin-1, -3, -6, and -11, tumor necrosis factor-α, and granulocyte macrophage-colony stimulating factor) on human osteoclast formation from circulating cells
    Yosuke Fujikawa, Afsaneh Sabokbar, S D Neale, Ichiro Itonaga, Takehiko Torisu, N A Athanasou · 2001 · Bone
13. Effect of strontium-substituted biphasic calcium phosphate on inflammatory mediators production by human monocytes
    Émilie Buache, Frédéric Velard, E. Bauden, C. Guillaume, Édouard Jallot, Jean‐Marie Nédélec, Dominique Laurent‐Maquin, Patrice Laquerrière · 2012 · Acta Biomaterialia
14. Constitutive and Induced IL-18 Receptor Expression by Various Peripheral Blood Cell Subsets as Determined by Anti-hIL-18R Monoclonal Antibody
    Toshio Kunikata, Kakuji Torigoe, Shimpei Ushio, Takanori Okura, Chie Ushio, Hiroshi Yamauchi, Masao Ikeda, Hakuo Ikegami, Masashi Kurimoto · 1998 · Cellular Immunology
15. Cytokine‐controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: Fibroblast‐mediated pathologic bone resorption
    Miklós Tunyogi-Csapó, Katalin Kis‐Tóth, Marianna Radács, Bálint Farkas, Joshua James Jacobs, Alison Finnegan, Katalin Mikecz, Tibor T. Glant · 2008 · Arthritis & Rheumatism
16. Effects of IL-23 and IL-27 on osteoblasts and osteoclasts: inhibitory effects on osteoclast differentiation
    Sadahiro Kamiya, Chika Nakamura, Takeshi Fukawa, Katsuhiro Ono, Toshiyuki Ohwaki, Takayuki Yoshimoto, Seiki Wada · 2007 · Journal of Bone and Mineral Metabolism
17. Interleukin-18 Up-Regulates Osteoprotegerin Expression in Stromal/Osteoblastic Cells
    Chiaki Makiishi-Shimobayashi, Tohru Tsujimura, Teruo Iwasaki, Naoko Yamada, Ayako Sugihara, Haruki Okamura, Shinichi Hayashi, Nobuyuki Terada · 2001 · Biochemical and Biophysical Research Communications
18. Inhibition of RANKL-induced osteoclast formation in mouse bone marrow cells by IL-12: involvement of IFN-gamma possibly induced from non-T cell population.
    N. Nagata, Hideki Kitaura, N. Yoshida, K. Nakayama · 2003 · Bone
19. Interleukin-18 Induces Rheumatoid Arthritis Synovial Fibroblast CXC Chemokine Production through NFκB Activation
    Jacques Morel, Christy C. Park, Pawan Kumar, Alisa Erika Koch · 2001 · Laboratory Investigation
20. Interleukin-18: Perspectives on the Newest Interleukin
    Matthew T. Gillespie, Nicole J. Horwood · 1998 · Cytokine & Growth Factor Reviews
21. Megakaryocyte-mediated inhibition of osteoclast development
    Melissa A. Kacena, Tracy Nelson, Mary E. Clough, Sun‐Kyeong Lee, Joseph A. Lorenzo, Caren M. Gundberg, Mark C. Horowitz · 2006 · Bone
22. The Pro-atherogenic Cytokine Interleukin-18 Induces CXCL16 Expression in Rat Aortic Smooth Muscle Cells via MyD88, Interleukin-1 Receptor-associated Kinase, Tumor Necrosis Factor Receptor-associated Factor 6, c-Src, Phosphatidylinositol 3-Kinase, Akt, c-Jun N-terminal Kinase, and Activator Protein-1 Signaling
    Bysani Chandrasekar, Srinivas Mummidi, Anthony J. Valente, Devang N. Patel, Steven R. Bailey, Gregory L. Freeman, Masahiko Hatano, Takeshi Tokuhisa, Liselotte E. Jensen · 2005 · Journal of Biological Chemistry
23. Interleukin-18 Promotes Joint Inflammation and Induces Interleukin-1-Driven Cartilage Destruction
    Leo A. B. Joosten, Ruben L. Smeets, Marije I. Koenders, Liduine A. M. van den Bersselaar, Monique M. A. Helsen, Birgitte Oppers‐Walgreen, Erik Lubberts, Yoichiro Iwakura, Fons A. J. van de Loo, Wim B. van den Berg · 2004 · American Journal Of Pathology
24. Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS
    Sugama, Shuei, Cho, Byung Pil, Baker, Harriet, Joh, Tong H, Lucero, Jacinta, Conti, Bruno · 2002 · Brain Research
25. Cytokines in the pathogenesis of osteoporosis
    Evan Romas, T. John Martin · 1997 · Osteoporosis International
26. Interleukin-18 and interleukin-12 synergistically inhibit osteoclastic bone-resorbing activity
    N Yamada, S. Niwa, Tohru Tsujimura, T. Iwasaki, Ayako Sugihara, Hiroyuki Futani, Shinichi Hayashi, Haruki Okamura, Hitoshi Akedo, Nobuyuki Terada · 2002 · Bone
27. Osteoprotegerin Overexpression by Breast Cancer Cells Enhances Orthotopic and Osseous Tumor Growth and Contrasts with That Delivered Therapeutically
    Jane Fisher, Rachel J. Thomas-Mudge, Jan Elliott, Daphne K. Hards, Natalie A. Sims, John Slavin, Thomas John Martin, Matthew T. Gillespie · 2006 · Cancer Research
28. Endogenous interleukin-18 modulates immune escape of murine melanoma cells by regulating the expression of Fas ligand and reactive oxygen intermediates.
    D Cho, H Song, Yong-Man Kim, D Houh, Dae Young Hur, Hyun‐Jeong Park, Do‐Young Yoon, K H Pyun, Woo Jung Lee, Masashi Kurimoto et al. · 2000 · PubMed
29. Counterregulation of Interleukin-18 mRNA and Protein Expression During Cutaneous Wound Repair in Mice
    Heiko Kämpfer, Heiko Mühl, Josef M. Pfeilschifter, Stefan Frank, Uwe Kalina · 1999 · Journal of Investigative Dermatology
30. IFN-γ Up-Regulates IL-18 Gene Expression Via IFN Consensus Sequence-Binding Protein and Activator Protein-1 Elements in Macrophages
    Yong-Man Kim, Joo Young Im, Seung Hyun Han, Hyung Sik Kang, Inpyo Choi · 2000 · The Journal of Immunology
31. Interleukin-33, a Target of Parathyroid Hormone and Oncostatin M, Increases Osteoblastic Matrix Mineral Deposition and Inhibits Osteoclast Formation in Vitro
    Hasnawati Saleh, Damien G. Eeles, Jason M. Hodge, Geoffrey C. Nicholson, Ran Gu, Sueli Pompolo, Matthew T. Gillespie, Julian M.W. Quinn · 2011 · Endocrinology
32. IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation
    Mohd Nizam Mansoori, Priyanka Shukla, Manisha Kakaji, Abdul Malik Tyagi, Kamini Srivastava, Manoj K. Shukla, Manisha Dixit, Jyoti Kureel, Sushil Kumar Gupta, Divya Ramesh Singh · 2016 · Scientific Reports
33. Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation
    Gerald J. Atkins, David R. Haynes, Sean M. Geary, M Loric, Tania N. Crotti, David M. Findlay · 2000 · Bone
34. Clinical importance of serum interleukin‐18 and nitric oxide activities in breast carcinoma patients
    Nazan Günel, Uğur Çoşkun, Banu Sancak, Uǧur Günel, Oğuz Hasdemır, Şükrü Bozkurt · 2002 · Cancer
35. Effect of Cytokines on Osteoclast Formation and Bone Resorption during Mechanical Force Loading of the Periodontal Membrane
    Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Haruki Sugisawa, Haruka Kohara, Masako Yoshimatsu, Teruko Takano‐Yamamoto · 2014 · The Scientific World JOURNAL
36. Prostaglandin E2 Is a Main Mediator in Receptor Activator of Nuclear Factor‐κB Ligand‐Dependent Osteoclastogenesis Induced by Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii
    Bong‐Kyu Choi, Sun‐Young Moon, Jeong‐Heon Cha, K. H. Kim, Yun‐Jung Yoo · 2005 · Journal of Periodontology
37. IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions
    Kohara, Haruka, Kitaura, Hideki, Fujimura, Yuji, Yoshimatsu, Masako, Morita, Yukiko, Eguchi, Toshiko, Masuyama, Ritsuko, Yoshida, Noriaki · 2011 · Immunology Letters
38. Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial ‘human osteoclastology’
    Shigeru Kotake, Toru Yago, Manabu Kawamoto, Yuki Nanke · 2011 · Journal of Bone and Mineral Metabolism
39. Bone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritis.
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40. Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity
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41. The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue
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42. Cultured human periodontal ligament cells constitutively express multiple osteotropic cytokines and growth factors, several of which are responsive to mechanical deformation
    M.N. Pinkerton, David C. Wescott, Benjamin J. Gaffey, Kyle T. Beggs, Trudy J. Milne, Murray C. Meikle · 2007 · Journal of Periodontal Research
43. T-Cells Mediate an Inhibitory Effect of Interleukin-4 on Osteoclastogenesis
    Danijela Mirosavljevic, Julian M.W. Quinn, Jan Elliott, Nicole J. Horwood, Thomas John Martin, Matthew T. Gillespie · 2003 · Journal of Bone and Mineral Research
44. Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus
    Monisha Banerjee · 2014 · World Journal of Diabetes
45. Mechanistic biomarkers for cytotoxic acute kidney injury
    Vishal S. Vaidya, Joseph Vincent Bonventre · 2006 · Expert Opinion on Drug Metabolism & Toxicology
46. TGF-β1 and IFN-γ Direct Macrophage Activation by TNF-α to Osteoclastic or Cytocidal Phenotype
    Simon W. Fox, Karen Fuller, Kathryn E. Bayley, Jenny M. Lean, Timothy John Chambers · 2000 · The Journal of Immunology
47. Interleukin-18 Is a Novel Mitogen of Osteogenic and Chondrogenic Cells
    Jill Cornish, Matthew T. Gillespie, K. E. Callon, Nicole J. Horwood, Jane M. Moseley, Ian R. Reid · 2003 · Endocrinology
48. Induction of Colony-Stimulating Factor Expression followingStaphylococcusorSalmonellaInteraction with Mouse or Human Osteoblasts
    Kenneth L. Bost, Jennifer L. Bento, John Kent Ellington, Ian Marriott, Michael C. Hudson · 2000 · Infection and Immunity
49. Interleukin-18 in Hemophagocytic Lymphohistiocytosis
    Hidetoshi Takada, Akihiko Nomura, Shouichi Ohga, Toshiro Hara · 2001 · Leukemia & lymphoma/Leukemia and lymphoma
50. Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment
    Shuei Sugama, S Wirz, Alasdair M. Barr, Bruno Conti, Tamás Bartfai, T. Shibasaki · 2004 · Neuroscience
51. Commitment and differentiation of stem cells to the osteoclast lineage
    Shin-Ichi Hayashi, Toshiyuki Yamane, Akitomo Miyamoto, Hiroaki Hemmi, Hisashi Tagaya, Yasuko Tanio, Hidenobu Kanda, Hidetoshi Yamazaki, Takahiro Kunisada · 1998 · Biochemistry and Cell Biology
52. Granulocyte/Macrophage Colony-Stimulating Factor and Interleukin-3 Correct Osteopetrosis in Mice with Osteopetrosis Mutation
    Yi Yi Myint, Kazuhisa Miyakawa, Makoto Naito, Leonard D. Shultz, Yuichi Oike, Ken–ichi Yamamura, Kiyoshi Takahashi · 1999 · American Journal Of Pathology
53. Interleukin-18: a therapeutic target in rheumatoid arthritis?
    Iain B. McInnes, Foo Yew Liew, J. Alastair Gracie · 2005 · Arthritis Research
54. Interleukin-18 (IL-18) and infectious diseases, with special emphasis on diseases induced by intracellular pathogens
    Isamu Sugawara · 2000 · Microbes and Infection
55. Interleukin 18
    Susan L. Swain · 2001 · The Journal of Experimental Medicine
56. The immune landscape in apical periodontitis: From mechanism to therapy
    Yuan‐Hao Wen, Yuxiu Lin, Lu Zhou, Lin Chen, Lu Zhang · 2024 · International Endodontic Journal
57. IL‐17 is involved in bone resorption in mouse periapical lesions
    Fumishige Oseko, Toshiro Yamamoto, Yuki Akamatsu, Narisato Kanamura, Yoichiro Iwakura, Jirô Imanishi, Masakazu Kita · 2009 · Microbiology and Immunology
58. The mechanism of osteoclast differentiation from macrophages: possible roles of T lymphocytes in osteoclastogenesis
    Nobuyuki Udagawa · 2003 · Journal of Bone and Mineral Metabolism
59. Plasma interleukin (IL)-18 (interferon-γ-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18
    T INOKUCHI, Y MORIWAKI, Hiroyuki Tsutsui, Ana Cláudia Yamamoto, S TAKAHASHI, Z. Tsutsumi, Tuneyoshhi Ka, K NAKANISHI, T YAMAMOTO · 2006 · Cytokine
60. Detection of the interleukin 18 family in rat brain by RT-PCR
    Rachel D. Wheeler, Aedín C. Culhane, Matthew D. Hall, Stuart M. Pickering-Brown, Nancy Jane Rothwell, Giamal N. Luheshi · 2000 · Molecular Brain Research
61. Unraveling Viral Interleukin-6 Binding to gp130 and Activation of STAT-Signaling Pathways Independently of the Interleukin-6 Receptor
    Nina Adam, Björn Rabe, Jan Suthaus, Joachim Grötzinger, Stefan Rose‐John, Jürgen Scheller · 2009 · Journal of Virology
62. Protein Inhibitor of Activated STAT 3 Modulates Osteoclastogenesis by Down-Regulation of NFATc1 and Osteoclast-Associated Receptor
    Kabsun Kim, Junwon Lee, Jung Ha Kim, Hye Mi Jin, Bin Zhou, Soo Young Lee, Nacksung Kim · 2007 · The Journal of Immunology
63. INTERLEUKIN 18—INTERFERON γ INDUCING FACTOR—A NOVEL PLAYER IN TUMOUR IMMUNOTHERAPY?
    Jakub Gołąb · 2000 · Cytokine
64. Close Association between Pulmonary Disease Manifestation inMycoplasma pneumoniaeInfection and Enhanced Local Production of Interleukin-18 in the Lung, Independent of Gamma Interferon
    Mitsuo Narita, Hiroshi Tanaka, Shosaku Abe, Satoshi Yamada, Mitsuru Kubota, Takehiro Togashi · 2000 · Clinical and Diagnostic Laboratory Immunology
65. Expression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic dermatitis
    Naoyuki Higashi, Borbala Gesser, Seiji Kawana, Kristian Thestrup‐Pedersen · 2001 · Journal of Allergy and Clinical Immunology
66. Gamma Interferon (IFN-γ) and IFN-γ-Inducing Cytokines Interleukin-12 (IL-12) and IL-18 Do Not Augment Infection-Stimulated Bone Resorption In Vivo
    Hajime Sasaki, Khaled Balto, Nobuyuki Kawashima, Jean W. Eastcott, Katsuaki Hoshino, Shizuo Akira, Philip Stashenko · 2004 · Clinical and Vaccine Immunology
67. Cellular targets of interleukin-18 in rheumatoid arthritis
    Sheng‐Ming Dai, Zheng-Zheng Shan, Huji Xu, Kusuki Nishioka · 2007 · Annals of the Rheumatic Diseases
68. IL-18 Inhibits Growth of Murine Orthotopic Prostate Carcinomas via Both Adaptive and Innate Immune Mechanisms
    Brian Wan-Chi Tse, Pamela Joan Russell, Matthias Lochner, Irmgard Förster, Carl Andrew Power · 2011 · PLoS ONE
69. The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro
    Alexia Grandjean-Laquerriere, Patrice Laquerrière, Dominique Laurent‐Maquin, Moncef Guenounou, Terry M. Phillips · 2004 · Biomaterials
70. Osteoclasts and Microgravity
    Smith, John Kelly · 2020 · Life
71. Interleukin-18 Is Regulated by Parathyroid Hormone and Is Required for Its Bone Anabolic Actions
    Liza Jane Raggatt, Ling Qin, Joseph A. Tamasi, Stephen C. Jefcoat, Emi Shimizu, Nagarajan Selvamurugan, Foo Yew Liew, Laura M. Bevelock, Jean H.M. Feyen, Nicola C. Partridge · 2007 · Journal of Biological Chemistry
72. Serum Levels of Interleukin-18 and sICAM-1 in Patients Affected by Breast Cancer: Preliminary Considerations
    R.A. Merendino, Sebastiano Gangemi, Antonella Ruello, A. Bene, Elena Losi, G. Lonbardo, F Purello-D'Ambrosio · 2001 · The International Journal of Biological Markers
73. Pathophysiological roles for IL-18 in inflammatory arthritis
    K. Matsui, H. Tsutsui, K. Nakanishi · 2003 · Expert opinion on therapeutic targets
74. The role of IL-18 in type 1 diabetic nephropathy: The problem and future treatment
    Nehal Mohsen Elsherbiny, Mohammed M.H. Al-Gayyar · 2016 · Cytokine
75. Human Osteoclast-Like Cells Are Formed from Peripheral Blood Mononuclear Cells in a Coculture with SaOS-2 Cells Transfected with the Parathyroid Hormone (PTH)/PTH-Related Protein Receptor Gene
    Kenichiro Matsuzaki, Kazuhiko Katayama, Yasuyuki Takahashi, Ichiro Nakamura, Nobuyuki Udagawa, Taro Tsurukai, Ryuichi Nishinakamura, Yoshiaki Toyama, Yutaka Yabe, Masayuki Hori et al. · 1999 · Endocrinology
76. Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases
    Mathilde Harel, Sébastien Fauteux‐Daniel, Charlotte Girard-Guyonvarc'h, Cem Gabay · 2021 · Cytokine
77. IL-18 Upregulates the Production of Key Regulators of Osteoclastogenesis from Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
    Wei jin Zhang, Xiaoliang Cong, Yanghua Qin, Zhengwen He, Dongyi He, Sheng‐Ming Dai · 2012 · Inflammation
78. Interleukin-18 Induces Retinal Pigment Epithelium Degeneration in Mice
    Ryo Ijima, Hiroki Kaneko, Fuxiang Ye, Yosuke Nagasaka, Kei Takayama, Keiko Kataoka, Shu Kachi, Takeshi Iwase, Hiroko Terasaki · 2014 · Investigative Ophthalmology & Visual Science
79. Interleukin-18 stimulates hematopoietic cytokine and growth factor formation and augments circulating granulocytes in mice
    Takeharu Ogura, Haruyasu Ueda, Katsushi Hosohara, Risa Tsuji, Yuki Nagata, Shin‐ichiro Kashiwamura, Haruki Okamura · 2001 · Blood
80. Modulation of IL-18 Production in the Adrenal Cortex following Acute ACTH or Chronic Corticosterone Treatment
    Bruno Conti, Shuei Sugama, Yoonseong Kim, Cristina Tinti, Hocheol Kim, Harriet A. Baker, Bruce T. Volpe, Barbara Attardi, Tong H. Joh · 2000 · NeuroImmunoModulation
81. Association Between Il-18 Gene Promoter Polymorphisms and Inflammatory Bowel Disease in a Japanese Population
    Tetsuya Takagawa, K Tamura, N Takeda, T Tomita, Yoshio Ohda, K. Fukunaga, Nobuyuki Hida, K Ohnishi, K Hori, T Kosaka et al. · 2005 · Inflammatory Bowel Diseases
82. Bcl6 Is a Transcriptional Repressor for the IL-18 Gene
    Nobue Takeda, Masafumi Arima, Nobuhide Tsuruoka, Seiji Okada, Masahiko Hatano, Akemi Sakamoto, Yoichi Kohno, Takeshi Tokuhisa · 2003 · The Journal of Immunology
83. Raised serum levels of interleukin-8 and interleukin-18 in relation to bone metabolism in endogenous Cushing's syndrome
    Kristo, C, Godang, K, Ueland, T, Lien, E, Aukrust, P, Froland, SS, Bollerslev, J · 2002 · European Journal of Endocrinology
84. Interleukin-18 in multiple myeloma patients: serum levels in relation to response to treatment and survival
    Michael G. Alexandrakis, Freda H. Passam, Katerina Sfiridaki, J. Moschandrea, Constantina A. Pappa, Dimitra Liapi, Elisa Petreli, Parascevi Roussou, D. S. Kyriakou · 2003 · Leukemia Research
85. Tissue-Specific Expression of Rat IL-18 Gene and Response to Adrenocorticotropic Hormone Treatment
    Shuei Sugama, Yoonseong Kim, Harriet A. Baker, Cristina Tinti, Hocheol Kim, Tong H. Joh, Bruno Conti · 2000 · The Journal of Immunology
86. IL‐18 is Present at the Maternal–Fetal Interface and Enhances Cytotoxic Activity of Decidual Lymphocytes
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87. Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor Inhibits Tumor Necrosis Factor (TNF)-α-induced Osteoclast Differentiation by Down-regulation of Expression of TNF Receptors 1 and 2
    S.D. Yogesha, Shruti M. Khapli, Mohan R. Wani · 2005 · Journal of Biological Chemistry
88. Correlation between plasma, synovial fluid and articular cartilage Interleukin-18 with radiographic severity in 33 patients with osteoarthritis of the knee
    Youhua Wang, Dawei Xu, Long Long, Xiaolong Deng, Ran Tao, Guicheng Huang · 2013 · Clinical and Experimental Medicine
89. Expression of cytokines IL-4, IL-12, IL-15, IL-18, and IFNγ and modulation by different growth factors in cultured human osteoblast-like cells
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90. Hormonal Regulation of Osteoclast Function
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91. Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts
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92. Abrogation of Viral Interleukin-6 (vIL-6)-Induced Signaling by Intracellular Retention and Neutralization of vIL-6 with an Anti-vIL-6 Single-Chain Antibody Selected by Phage Display
    Marina Kovaleva, Ingo Bußmeyer, Björn Rabe, Joachim Grötzinger, Enge Sudarman, Jutta Eichler, Udo Conrad, Stefan Rose‐John, Jürgen Scheller · 2006 · Journal of Virology
93. Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-γ, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines
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94. Increased Levels of Serum lnterleukin-18 in Graves' Disease
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95. Effect of T cells on bone
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96. IL-18 Inhibits TNF-α-Induced Osteoclastogenesis Possibly via a T Cell-Independent Mechanism in Synergy with IL-12 In Vivo
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97. Bone Malformations in Interleukin-18 Transgenic Mice
    Yusuke Kawase, Tomoaki Hoshino, Koichi Yokota, Akemi Kuzuhara, Masanori Nakamura, Yu Maeda, Eiji Nishiwaki, Michihisa Zenmyo, Koji Hiraoka, Hisamichi Aizawa et al. · 2003 · Journal of Bone and Mineral Research
98. Expression of interleukin‐18 and its monokine‐directed function in rheumatoid arthritis
    Burkhard Möller, Natasa Kukoc-Zivojnov, U. Kessler, Stefan Rehart, Joachim Peter Kaltwasser, David T. Hoelzer, Uwe Kalina, Oliver Gerhard Ottmann · 2001 · Lara D. Veeken
99. T-cell involvement in osteoclast biology: implications for rheumatoid bone erosion
    Donncha O’Gradaigh, Juliet Elizabeth Compston · 2003 · Rheumatology
100. Exploring the Role of Hormones and Cytokines in Osteoporosis Development
     Egemen Umur, Safiye Betül Bulut, Pelin Yiğit, Emirhan Bayrak, Yaren Arkan, Fahriye Arslan, Engin Baysoy, Gizem Kaleli‐Can, Bugra Ayan · 2024 · Biomedicines