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Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy
Open accessAbstract
Ultraviolet A (UVA) irradiation is effectively used to treat patients with atopic dermatitis and other T cell mediated, inflammatory skin diseases. In the present study, successful phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis in skin-infiltrating T helper cells, leading to T cell depletion from eczematous skin. In vitro, UVA radiation-induced human T helper cell apoptosis was mediated through the FAS/FAS-ligand system, which was activated in irradiated T cells as a consequence of singlet oxygen generation. These studies demonstrate that singlet oxygen is a potent trigger for the induction of human T cell apoptosis. They also identify singlet oxygen generation as a fundamental mechanism of action operative in phototherapy.
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Citations
Cited by
Wollenberg, A., Barbarot, S., Bieber, T., Christen‐Zaech, S., Deleuran, M., Fink‐Wagner, A., Gieler, U., Girolomoni, G., Lau, S., Muraro, A., et al. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14891 · Cited by 1,181
Self-citationLight-Emitting Diodes (LEDs) in Dermatology
Barolet, D. (2008) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2008.08.003 · Cited by 435
Symposium‐in‐Print: Singlet Oxygen Invited Review
Redmond, R. W., & Kochevar, I. E. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-04-14-ir-874 · Cited by 421
Molecular mechanisms of UV-induced apoptosis
Kulms, D., & Schwarz, T. (2000) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2000.160501.x · Cited by 319
Ozawa, M., Ferenczi, K., Kikuchi, T., Cardinale, I., Austin, L. M., Coven, T. R., Burack, L. H., & Krueger, J. G. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.711 · Cited by 298
Metadata
- Authors
- Morita, A., Werfel, T., Stege, H., Ahrens, C., Karmann, K., Grewe, M., Grether-Beck, S., Ruzicka, T., Kapp, A., Klotz, L.-O., Sies, H., & Krutmann, J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-11-17
- Volume
- 186
- Issue
- 10
- Pages
- 1763-1768
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2109266458
- Cited by
- 280
- References
- 0
- FWCI
- 20.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy. https://app.cochat.ai/papers/10.1084/jem.186.10.1763
- The paper
- Morita, A., Werfel, T., Stege, H., Ahrens, C., Karmann, K., Grewe, M., Grether-Beck, S., Ruzicka, T., Kapp, A., Klotz, L.-O., Sies, H., & Krutmann, J. (1997). Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.186.10.1763
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
