Molecular mechanisms of UV-induced apoptosis
Open accessAbstract
Sunburn cells, single standing cells with typical morphologic features occurring in UV‐exposed skin, have been recognized as keratinocytes undergoing apoptosis following UV irradiation. Induction of apoptosis following UV exposure appears to be a protective mechanism, getting rid off severely damaged cells that bear the risk of malignant transformation. UV‐mediated apoptosis is a highly complex process in which different molecular pathways are involved. These include DNA damage, activation of the tumor suppressor gene p53, triggering of cell death receptors either directly by UV or by autocrine release of death ligands, mitochondrial damage and cytochrome C release. Detailed knowledge about the interplay between these pathways will increase our understanding of photocarcinogenesis. This review briefly discusses recent findings concerning the molecular mechanisms underlying UV‐induced apoptosis.
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UV rays first encounter the uppermost epidermal keratinocytes and cause apoptosis.
“UV rays first encounter the uppermost epidermal keratinocytes causing apoptosis.”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [22]
The Abstract identifies sunburn cells in UV-exposed skin as keratinocytes undergoing apoptosis after UV irradiation, and the Conclusion likewise discusses UV-induced keratinocyte apoptosis. Our copy does not say that UV rays first encounter the uppermost epidermal keratinocytes or locate the apoptotic cells specifically in that layer. Page numbers are unavailable in the indexed passages. (LLM, conf=0.83)
Experimental — accuracy not yet measuredA prototype of UV-induced apoptosis of keratinocytes is the formation of epidermal sunburn cells that are destined to apoptosis after sun exposure.
“A prototype of UV-induced apoptosis of keratinocytes is the formation of epidermal sunburn cells that are destined to apoptosis after sun exposure [22].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [22]
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Cites
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., & Fusenig, N. E. (1988) · The Journal of cell biology · doi:10.1083/jcb.106.3.761 · Cited by 4,170 · see citing works
Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
Stege, H., Roza, L., Vink, A. A., Grewe, M., Ruzicka, T., Grether-Beck, S., & Krutmann, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030528897 · Cited by 292 · see citing works
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Nitric oxide and wound repair: role of cytokines?
Schwentker, A., Vodovotz, Y., Weller, R., & Billiar, T. R. (2002) · Nitric Oxide · doi:10.1016/s1089-8603(02)00002-2 · Cited by 386 · see citing works
Nutritional protection against skin damage from sunlight
Sies, H., & Stahl, W. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132320 · Cited by 307 · see citing works
Caspase-14 protects against epidermal UVB photodamage and water loss
Denecker, G., Hoste, E., Gilbert, B., Hochepied, T., Ovaere, P., Lippens, S., Van den Broecke, C., Van Damme, P., D'Herde, K., Hachem, J.-P., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1597 · Cited by 298 · see citing works
Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works
Hseu, Y.-C., Chou, C.-W., Senthil Kumar, K. J., Fu, K.-T., Wang, H.-M., Hsu, L.-S., Kuo, Y.-H., Wu, C.-R., Chen, S.-C., & Yang, H.-L. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.02.020 · Cited by 239 · see citing works
Gentile, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg675 · Cited by 185 · see citing works
Subedi, L., Lee, T. H., Wahedi, H. M., Baek, S.-H., & Kim, S. Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8379539 · Cited by 174 · see citing works
Carotenoids and Flavonoids Contribute to Nutritional Protection against Skin Damage from Sunlight
Stahl, W., & Sies, H. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0051-z · Cited by 170 · see citing works
Sies, H., & Stahl, W. (2004) · Photochemical & Photobiological Sciences · doi:10.1039/b316082c · Cited by 113 · see citing works
Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer
Jans, J., Garinis, G. A., Schul, W., van Oudenaren, A., Moorhouse, M., Smid, M., Sert, Y.-G., van der Velde, A., Rijksen, Y., de Gruijl, F. R., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00807-06 · Cited by 56 · see citing works
Petruk, G., Raiola, A., Del Giudice, R., Barone, A., Frusciante, L., Rigano, M. M., & Monti, D. M. (2016) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2016.08.047 · Cited by 55 · see citing works
Petruk, G., Illiano, A., Del Giudice, R., Raiola, A., Amoresano, A., Rigano, M. M., Piccoli, R., & Monti, D. M. (2017) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2017.05.013 · Cited by 50 · see citing works
Petruk, G., Di Lorenzo, F., Imbimbo, P., Silipo, A., Bonina, A., Rizza, L., Piccoli, R., Monti, D. M., & Lanzetta, R. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.10.043 · Cited by 45 · see citing works
Lee, H.-J., Lee, J.-Y., Song, K.-C., Kim, J.-H., Park, J.-H., Chun, K.-H., & Hwang, G.-S. (2012) · Journal of Ginseng Research · doi:10.5142/jgr.2012.36.1.68 · Cited by 40 · see citing works
Mechanisms and Therapeutic Roles of Medicinal Plants in Skin Photoaging
Lei, X. (2025) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s538326 · Cited by 9 · see citing works
Dorr, M. M., & Rochette, P. J. (2023) · PLOS ONE · doi:10.1371/journal.pone.0283572 · Cited by 6 · see citing works
- Authors
- Kulms, D., & Schwarz, T.
- Affiliations
- University of Münster (DE)
- ORCID
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 2000-10
- Volume
- 16
- Issue
- 5
- Pages
- 195-201
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W2066711970
- Cited by
- 319
- References
- 2
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 11 · 2018: 11 · 2017: 15 · 2016: 19 · 2015: 19 · 2014: 12 · 2013: 12 · 2012: 17
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (07UVB63A/5)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- UV-induced apoptosis, sunburn cells, keratinocytes, DNA damage, p53, tumor suppressor, death ligands, mitochondrial damage, cytochrome c release, photocarcinogenesis, malignant transformation
- MeSH terms
- DNA Damage, Humans, Ultraviolet Rays, Keratinocytes, Apoptosis, Receptors, Tumor Necrosis Factor, Proto-Oncogene Proteins c-bcl-2
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