The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
Open accessAbstract
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6−/−RM). Lymphogenesis in primary lymphoid tissues of Bcl6−/−RM is normal, and Bcl6−/−RM produced control levels of primary IgG1 antibodies specific to T cell–dependent antigens. However, GCs were not found in these mice. This defect was mainly due to the abnormalities of B cells. Therefore, Bcl6 is essential for the differentiation of GC B cells.
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Cites
RAG-1-deficient mice have no mature B and T lymphocytes
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Cited by
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
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DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES
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Metadata
- Authors
- Fukuda, T., Yoshida, T., Okada, S., Hatano, M., Miki, T., Ishibashi, K., Okabe, S., Koseki, H., Hirosawa, S., Taniguchi, M., Miyasaka, N., & Tokuhisa, T.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-08-04
- Volume
- 186
- Issue
- 3
- Pages
- 439-448
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2128243696
- Cited by
- 356
- References
- 54
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Fukuda, T., Yoshida, T., Okada, S., Hatano, M., Miki, T., Ishibashi, K., Okabe, S., Koseki, H., Hirosawa, S., Taniguchi, M., Miyasaka, N., & Tokuhisa, T. (1997). Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.186.3.439
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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