The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell–deficient Mice
Open accessAbstract
Mast cells are the main effector cells of immediate hypersensitivity and anaphylaxis. Their role in the development of allergen-induced airway hyperresponsiveness (AHR) is controversial and based on indirect evidence. To address these issues, mast cell–deficient mice (W/W v) and their congenic littermates were sensitized to ovalbumin (OVA) by intraperitoneal injection and subsequently challenged with OVA via the airways. Comparison of OVA-specific immunoglobulin E (IgE) levels in the serum and numbers of eosinophils in bronchoalveolar lavage fluid or lung digests showed no differences between the two groups of mice. Further, measurements of airway resistance and dynamic compliance at baseline and after inhalation of methacholine were similar. These data indicate that mast cells or IgE–mast cell activation is not required for the development of eosinophilic inflammation and AHR in mice sensitized to allergen via the intraperitoneal route and challenged via the airways.
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Cites
Allergy: Principles and Practice.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-817_10 · Cited by 1,696
Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores
Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P., & Paul, W. E. (1989) · Nature · doi:10.1038/339064a0 · Cited by 1,170
New Concepts about the Mast Cell
Flier, J. S., Underhill, L. H., & Galli, S. J. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301283280408 · Cited by 990
The Receptor with High Affinity for Immunoglobulin E
Metzger, H. (1986) · Annual Review of Immunology · doi:10.1146/annurev.immunol.4.1.419 · Cited by 543
Attenuation of allergic airway inflammation in IL‐4 deficient mice
BRUSSELLE, G. G., KIPS, J. C., TAVERNIER, J. H., VAN DER HEYDEN, J. G., CUVELIER, C. A., PAUWELS, R. A., & BLUETHMANN, H. (1994) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1994.tb00920.x · Cited by 431
Sorting out the cytokines of asthma.
Drazen, J. M., Arm, J. P., & Austen, K. F. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.1.1 · Cited by 375
The alpha 1-fetoprotein test in hepatocellular carcinoma.
Fox, H., Kondi, A., Linsell, C. A., PARKER, A. M., & Sizaret, P.-Y. (1970) · PubMed · Cited by 290
Mediators of immediate hypersensitivity
Wasserman, S. I. (1983) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(83)90512-2 · Cited by 288
Hamelmann, E., Oshiba, A., Loader, J., Larsen, G. L., Gleich, G., Lee, J., & Gelfand, E. W. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.3.9117011 · Cited by 260
Self-citationAllergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice
Korsgren, M., ält, J. S. E., Korsgren, O., Sundler, F., & Persson, C. G. A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.885 · Cited by 253
Cited by
MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,017
Williams, C. M. M., & Galli, S. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.455 · Cited by 400
Humbles, A. A., Lu, B., Friend, D. S., Okinaga, S., Lora, J., Al-garawi, A., Martin, T. R., Gerard, N. P., & Gerard, C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261462598 · Cited by 388
The diverse potential effector and immunoregulatory roles of mast cells in allergic disease
Williams, C. M. M., & Galli, S. J. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106485 · Cited by 355
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcεRI signals
Ho, L. H., Ohno, T., Oboki, K., Kajiwara, N., Suto, H., Iikura, M., Okayama, Y., Akira, S., Saito, H., Galli, S. J., et al. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407200 · Cited by 285
Metadata
- Authors
- Takeda, K., Hamelmann, E., Joetham, A., Shultz, L. D., Larsen, G. L., Irvin, C. G., & Gelfand, E. W.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-08-04
- Volume
- 186
- Issue
- 3
- Pages
- 449-454
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2124714277
- Cited by
- 395
- References
- 27
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Takeda, K., Hamelmann, E., Joetham, A., Shultz, L. D., Larsen, G. L., Irvin, C. G., & Gelfand, E. W. (1997). Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell–deficient Mice. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.186.3.449
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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