The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation
Open accessAbstract
Limited information is available on the surface molecules that are involved in natural killer (NK) cell triggering. In this study, we selected the BAB281 monoclonal antibody (mAb) on the basis of its ability to trigger NK-mediated target cell lysis. BAB281 identified a novel NK cell–specific surface molecule of 46 kD (p46) that is expressed by all resting or activated NK cells. Importantly, unlike the NK cell antigens identified so far, the expression of p46 was strictly confined to NK cells. Upon mAb-mediated cross-linking, p46 molecules induced strong cell triggering leading to [Ca2+]i increases, lymphokine production, and cytolytic activity both in resting NK cells and NK cell clones. The p46-mediated induction of Ca2+ increases or triggering of cytolytic activity was downregulated by the simultaneous engagement of inhibitory receptors including p58, p70, and CD94/NKG2A. Both the unique cellular distribution and functional capability of p46 molecules suggest a possible role in the mechanisms of non-major histocompatibility complex–restricted cytolysis mediated by human NK cells.
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Cites
1 retracted
Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity
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RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS
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Self-citationColonna, M., & Samaridis, J. (1995) · Science · doi:10.1126/science.7716543 · Cited by 736
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Self-citationMHC Class I Deficiency: Susceptibility to Natural Killer (NK) Cells and Impaired NK Activity
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Cited by
Caligiuri, M. A. (2008) · Blood · doi:10.1182/blood-2007-09-077438 · Cited by 1,905
REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
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Targeting natural killer cells and natural killer T cells in cancer
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Metadata
- Authors
- Sivori, S., Vitale, M., Morelli, L., Sanseverino, L., Augugliaro, R., Bottino, C., Moretta, L., & Moretta, A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-10-06
- Volume
- 186
- Issue
- 7
- Pages
- 1129-1136
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2058522060
- Cited by
- 554
- References
- 32
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Sivori, S., Vitale, M., Morelli, L., Sanseverino, L., Augugliaro, R., Bottino, C., Moretta, L., & Moretta, A. (1997). p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.186.7.1129
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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