The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA
Open accessAbstract
A major virulence factor in the stomach chronic infection by Helicobacter pylori is a protein toxin (VacA), which alters cell membrane trafficking of late endosomal/prelysosomal compartments. Its role in the chronic infection established by H. pylori is unknown. To test the possibility that VacA alters antigen processing taking place in prelysosomal compartments, we have used the well-established model of antigen processing and presentation consisting of tetanus toxoid–specific human (CD4+) T cells stimulated by autologous antigen-pulsed Epstein-Barr virus-transformed B cells. We found that VacA interferes with proteolytic processing of tetanus toxin and toxoid and specifically inhibits the Ii-dependent pathway of antigen presentation mediated by newly synthesized major histocompatibility complex (MHC) class II, while leaving unaffected the presentation pathway dependent on recycling MHC class II. The results presented here suggest that VacA may contribute to the persistence of H. pylori by interfering with protective immunity and that this toxin is a new useful tool in the study of the different pathways of antigen presentation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional diversity of helper T lymphocytes
Abbas, A. K., Murphy, K. M., & Sher, A. (1996) · Nature · doi:10.1038/383787a0 · Cited by 4,450
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Censini, S., Lange, C., Xiang, Z., Crabtree, J. E., Ghiara, P., Borodovsky, M., Rappuoli, R., & Covacci, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14648 · Cited by 1,872
Self-citationAntigen-specific interaction between T and B cells
Lanzavecchia, A. (1985) · Nature · doi:10.1038/314537a0 · Cited by 1,412
Self-citationAn international association between Helicobacter pylori infection and gastric cancer
The EUROGAST Study Group (1993) · The Lancet · doi:10.1016/0140-6736(93)90938-d · Cited by 1,155
Assembly, Transport, and Function of MHC Class II Molecules
Cresswell, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.259 · Cited by 807
CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES
Watts, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.821 · Cited by 763
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.
Peters, P. J., Borst, J., Oorschot, V, Fukuda, M., Krähenbühl, O., Tschopp, J., Slot, J. W., & Geuze, H. J. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.5.1099 · Cited by 713
Kägi, D., Ledermann, B., Bürki, K., Zinkernagel, R. M., & Hengartner, H. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.207 · Cited by 588
Ziegler, H. K., & Unanue, E. R. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.1.175 · Cited by 570
Cited by
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Host-Bacterial Interactions in Helicobacter pylori Infection
Amieva, M. R., & El–Omar, E. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.009 · Cited by 632
THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES
Atherton, J. C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100125 · Cited by 567
Helicobacter pylori Vacuolating Cytotoxin Inhibits T Lymphocyte Activation
Gebert, B., Fischer, W., Weiss, E., Hoffmann, R., & Haas, R. (2003) · Science · doi:10.1126/science.1086871 · Cited by 567
Geographic distribution of vacA allelic types of Helicobacter pylori
Van Doorn, L., Figueiredo, C., Mégraud, F., Pena, S., Midolo, P., De Magalhães Queiroz, D. M., Carneiro, F., Vanderborght, B., Pegado, M. D. G. F., Sanna, R., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70065-x · Cited by 444
Metadata
- Authors
- Molinari, M., Salio, M., Galli, C., Norais, N., Rappuoli, R., Lanzavecchia, A., & Montecucco, C.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-01-05
- Volume
- 187
- Issue
- 1
- Pages
- 135-140
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2063666087
- Cited by
- 288
- References
- 30
- FWCI
- 18.87
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA. https://app.cochat.ai/papers/10.1084/jem.187.1.135
- The paper
- Molinari, M., Salio, M., Galli, C., Norais, N., Rappuoli, R., Lanzavecchia, A., & Montecucco, C. (1998). Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.187.1.135
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
