The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Helicobacter pylori Vacuolating Cytotoxin Inhibits T Lymphocyte Activation
Abstract
Helicobacter pylori ( Hp ) vacuolating cytotoxin VacA induces cellular vacuolation in epithelial cells. We found that VacA could efficiently block proliferation of T cells by inducing a G 1 /S cell cycle arrest. It interfered with the T cell receptor/interleukin-2 (IL-2) signaling pathway at the level of the Ca 2 + -calmodulin–dependent phosphatase calcineurin. Nuclear translocation of nuclear factor of activated T cells (NFAT), a transcription factor acting as a global regulator of immune response genes, was abrogated, resulting in down-regulation of IL-2 transcription. VacA partially mimicked the activity of the immunosuppressive drug FK506 by possibly inducing a local immune suppression, explaining the extraordinary chronicity of Hp infections.
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Transcriptional regulation of the IL-2 gene
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A Bacterial Toxin That Controls Cell Cycle Progression as a Deoxyribonuclease I-Like Protein
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Grb2 Is a Key Mediator of Helicobacter pylori CagA Protein Activities
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Cited by
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Helicobacter pylori: gastric cancer and beyond
Polk, D. B., & Peek, R. M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2857 · Cited by 1,158
Inflammation, atrophy, and gastric cancer
Fox, J. G., & Wang, T. C. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30111 · Cited by 772
Fusobacterium nucleatum and T Cells in Colorectal Carcinoma
Mima, K., Sukawa, Y., Nishihara, R., Qian, Z. R., Yamauchi, M., Inamura, K., Kim, S. A., Masuda, A., Nowak, J. A., Nosho, K., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1377 · Cited by 669
Mechanisms of disease: Helicobacter pylori virulence factors
Yamaoka, Y. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.154 · Cited by 666
Metadata
- Authors
- Gebert, B., Fischer, W., Weiss, E., Hoffmann, R., & Haas, R.
- Venue
- Science
- Published
- 2003-08-22
- Volume
- 301
- Issue
- 5636
- Pages
- 1099-1102
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2154940764
- Cited by
- 567
- References
- 22
- FWCI
- 40.11
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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