Cited by 165Tuberculosis Research and EpidemiologyImmunotherapy and Immune ResponsesT-cell and B-cell Immunology

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Characterization of Human CD8+ T Cells Reactive with Mycobacterium tuberculosis–infected Antigen-presenting Cells

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Lewinsohn, David M., Alderson, Mark R., Briden, Andria L., Riddell, Stanley R., Reed, Steven G., Grabstein, Kenneth H.·1998·The Journal of Experimental Medicine

DOI 10.1084/jem.187.10.1633PMC PMC2212289

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Abstract

Previous studies in murine models, including those using the β2 microglobulin knockout mouse, have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). At present, little is understood about these cells in the human immune response to tuberculosis. This report demonstrates the existence of human Mtb-reactive CD8+ T cells. These cells are present preferentially in persons infected with Mtb and produce interferon γ in response to stimulation with Mtb-infected target cells. Recognition of Mtb-infected cells by these CD8+ T cells is restricted neither by the major histocompatibility complex (MHC) class I A, B, or C alleles nor by CD1, although it is inhibited by anti–MHC class I antibody. The Mtb-specific CD8+ T cells recognize an antigen which is generated in the proteasome, but which does not require transport through the Golgi-ER. The data suggest the possible use of nonpolymorphic MHC class Ib antigen presenting structures other than CD1.

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Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A., & Bloom, B. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2249 · Cited by 2,468
Proliferating dendritic cell progenitors in human blood.
Romani, N., Grüner, S., Brang, D., Kämpgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P. O., Steinman, R. M., & Schuler, G. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.83 · Cited by 1,841
Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice
Flynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schrelber, R., Mak, T. W., & Bloom, B. R. (1995) · Immunity · doi:10.1016/1074-7613(95)90001-2 · Cited by 1,678
Recognition of a lipid antigen by CD1-restricted αβ+ T cells
Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994) · Nature · doi:10.1038/372691a0 · Cited by 977
The global tuberculosis situation and the new control strategy of the World Health Organization
Kochi, A. (1991) · Tubercle · doi:10.1016/0041-3879(91)90017-m · Cited by 849
Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.
Flynn, J. L., Goldstein, M. M., Triebold, K. J., Koller, B. H., & Bloom, B. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12013 · Cited by 793
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
Huygen, K., Content, J., Denis, O., Montgomery, D. L., Yawman, A. M., Deck, R. R., DeWitt, C. M., Orme, I. M., Baldwin, S. L., D'Souza, C. D., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-893 · Cited by 628
Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., & Harding, C. V. (1993) · Nature · doi:10.1038/361359a0 · Cited by 615 · cited 2×
“However, particulate antigens have been shown to gain access to the MHC class I pathway (18, 19), although the efficiency of these pathways remains controversial (20).”
Background
Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.
Kovacsovics-Bankowski, M., Clark, K., Benacerraf, B., & Rock, K. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.4942 · Cited by 601
CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen
Porcelli, S. A., Morita, C. T., & Brenner, M. B. (1992) · Nature · doi:10.1038/360593a0 · Cited by 572

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Authors: Lewinsohn, D. M., Alderson, M. R., Briden, A. L., Riddell, S. R., Reed, S. G., & Grabstein, K. H.
Affiliations: Infectious Disease Research Institute (US)
Corresponding author: Lewinsohn, David M.
ORCID: Lewinsohn, David M.
Alderson, Mark R.
Riddell, Stanley R.
Reed, Steven G.
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 1998-05-18
Volume: 187
Issue: 10
Pages: 1633-1640
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.187.10.1633
PMC: PMC2212289
OpenAlex: W2111354206
Cited by: 165
References: 33
Citations by year: 2026: 2 · 2025: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 6
FWCI: 16.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (5T32 HL-07287, T32HL007287)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: CD8+ T cells, Mycobacterium tuberculosis, tuberculosis, interferon-gamma, MHC class I restriction, MHC class Ib, antigen presentation, human immune response
MeSH terms: Acetylcysteine, Amino Acid Sequence, Animals, Chloroquine, Humans, Lymphocyte Cooperation, Molecular Sequence Data, Mycobacterium tuberculosis, Tuberculosis, Cysteine Proteinase Inhibitors, Antigen Presentation, CD8-Positive T-Lymphocytes, Mice

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Characterization of Human CD8+ T Cells Reactive with Mycobacterium tuberculosis–infected Antigen-presenting Cells

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