The DOI matches its Crossref record.
Generation of Memory B Cells and Plasma Cells in Vitro
Abstract
After germinal center B cells undergo somatic mutation and antigen selection, they become either memory B cells or plasma cells, but the signal requirements that control entry into either pathway have been unclear. When purified human germinal center cells were cultured with interleukin-2, interleukin-10, and cells expressing CD40 ligand, cells with characteristics of memory B cells were generated. Removal of CD40 ligand from the system resulted in terminal differentiation of germinal center B cells into cells with the characteristics of plasma cells. These results indicate that CD40 ligand directs the differentiation of germinal center B cells toward memory B cells rather than toward plasma cells.
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Citations
Cited by
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Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141
Jenks, S. A., Cashman, K. S., Zumaquero, E., Marigorta, U. M., Patel, A. V., Wang, X., Tomar, D., Woodruff, M. C., Simon, Z., Bugrovsky, R., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.015 · Cited by 1,078
Jego, G., Palucka, A. K., Blanck, J.-P., Chalouni, C., Pascual, V., & Banchereau, J. (2003) · Immunity · doi:10.1016/s1074-7613(03)00208-5 · Cited by 1,067
Self-citationDetecting shared pathogenesis from the shared genetics of immune-related diseases
Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551
Metadata
- Authors
- Arpin, C., Déchanet, J., Van Kooten, C., Merville, P., Grouard, G., Brière, F., Banchereau, J., & Liu, Y.-J.
- Venue
- Science
- Published
- 1995-05-05
- Volume
- 268
- Issue
- 5211
- Pages
- 720-722
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026549568
- Cited by
- 571
- References
- 0
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arpin, C., Déchanet, J., Van Kooten, C., Merville, P., Grouard, G., Brière, F., Banchereau, J., & Liu, Y.-J. (1995). Generation of Memory B Cells and Plasma Cells in Vitro. Science. https://doi.org/10.1126/science.7537388
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
