The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Protective Heterologous Antiviral Immunity and Enhanced Immunopathogenesis Mediated by Memory T Cell Populations
Open accessAbstract
A basic principle of immunology is that prior immunity results in complete protection against a homologous agent. In this study, we show that memory T cells specific to unrelated viruses may alter the host's primary immune response to a second virus. Studies with a panel of heterologous viruses, including lymphocytic choriomeningitis (LCMV), Pichinde (PV), vaccinia (VV), and murine cytomegalo (MCMV) viruses showed that prior immunity with one of these viruses in many cases enhanced clearance of a second unrelated virus early in infection. Such protective immunity was common, but it depended on the virus sequence and was not necessarily reciprocal. Cell transfer studies showed that both CD4 and CD8 T cell populations from LCMV-immune mice were required to transfer protective immunity to naive hosts challenged with PV or VV. In the case of LCMV-immune versus naive mice challenged with VV, there was an enhanced early recruitment of memory phenotype interferon (IFN) γ–secreting CD4+ and CD8+ cells into the peritoneal cavity and increased IFN-γ levels in this initial site of virus replication. Studies with IFN-γ receptor knockout mice confirmed a role for IFN-γ in mediating the protective effect by LCMV-immune T cell populations when mice were challenged with VV but not PV. In some virus sequences memory cell populations, although clearing the challenge virus more rapidly, elicited enhanced IFN-γ–dependent immunopathogenesis in the form of acute fatty necrosis. These results indicate that how a host responds to an infectious agent is a function of its history of previous infections and their influence on the memory T cell pool.
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Cites
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Cited by
Epstein-Barr virus: exploiting the immune system
Thorley-Lawson, D. A. (2001) · Nature Reviews Immunology · doi:10.1038/35095584 · Cited by 939
Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, A. B., Williams, M. A., Jones, T. R., Shirasugi, N., Durham, M. M., Kaech, S. M., Wherry, E. J., Onami, T., Lanier, J. G., Kokko, K. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317477 · Cited by 616
Selin, L. K., Lin, M. Y., Kraemer, K. A., Pardoll, D. M., Schneck, J. P., Varga, S. M., Santolucito, P. A., Pinto, A. K., & Welsh, R. M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80147-8 · Cited by 275
Self-citationMemory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung
Chen, H. D., Fraire, A. E., Joris, I., Brehm, M. A., Welsh, R. M., & Selin, L. K. (2001) · Nature Immunology · doi:10.1038/ni727 · Cited by 259
Self-citationT Cell Responses in Dengue Hemorrhagic Fever: Are Cross-Reactive T Cells Suboptimal?
Mongkolsapaya, J., Duangchinda, T., Dejnirattisai, W., Vasanawathana, S., Avirutnan, P., Jairungsri, A., Khemnu, N., Tangthawornchaikul, N., Chotiyarnwong, P., Sae-Jang, K., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3821 · Cited by 258
Metadata
- Authors
- Selin, L. K., Varga, S. M., Wong, I. C., & Welsh, R. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-11-02
- Volume
- 188
- Issue
- 9
- Pages
- 1705-1715
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2026973139
- Cited by
- 273
- References
- 46
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Selin, L. K., Varga, S. M., Wong, I. C., & Welsh, R. M. (1998). Protective Heterologous Antiviral Immunity and Enhanced Immunopathogenesis Mediated by Memory T Cell Populations. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.188.9.1705
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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