The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
T Cell Responses in Dengue Hemorrhagic Fever: Are Cross-Reactive T Cells Suboptimal?
Abstract
Dengue virus infection poses a growing public health and economic burden in a number of tropical and subtropical countries. Dengue circulates as a number of quasispecies, which can be divided by serology into four groups or serotypes. An interesting feature of Dengue, recognized over five decades ago, is that most severe cases that show hemorrhagic fever are not suffering from a primary infection. Instead, they are reinfected with a virus of different serotype. This observation poses considerable problems in vaccine design, and it is therefore imperative to gain a full understanding of the mechanisms underlying this immunological enhancement of disease. In this study, we examined a T cell epitope restricted by HLA-A*24, a major MHC class I allele, in Southeast Asia in a cohort of children admitted to a hospital with acute Dengue infection. The cytokine profiles and the degranulation capacity of T cells generated to this epitope are defined and compared across different viral serotypes. Cross-reactive Dengue-specific T cells seem to show suboptimal degranulation but high cytokine production, which may contribute to the development of the vascular leak characteristic of Dengue hemorrhagic fever.
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Citations
Cites
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Cited by
Global Spread and Persistence of Dengue
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Dengue virus life cycle: viral and host factors modulating infectivity
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Pathogenesis of vascular leak in dengue virus infection
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Immune-mediated cytokine storm and its role in severe dengue
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Metadata
- Authors
- Mongkolsapaya, J., Duangchinda, T., Dejnirattisai, W., Vasanawathana, S., Avirutnan, P., Jairungsri, A., Khemnu, N., Tangthawornchaikul, N., Chotiyarnwong, P., Sae-Jang, K., Koch, M., Jones, Y., McMichael, A., Xu, X., Malasit, P., & Screaton, G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03
- Volume
- 176
- Issue
- 6
- Pages
- 3821-3829
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1482072302
- Cited by
- 258
- References
- 25
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mongkolsapaya, J., Duangchinda, T., Dejnirattisai, W., Vasanawathana, S., Avirutnan, P., Jairungsri, A., Khemnu, N., Tangthawornchaikul, N., Chotiyarnwong, P., Sae-Jang, K., Koch, M., Jones, Y., McMichael, A., Xu, X., Malasit, P., & Screaton, G. (2006). T Cell Responses in Dengue Hemorrhagic Fever: Are Cross-Reactive T Cells Suboptimal? The Journal of Immunology. https://doi.org/10.4049/jimmunol.176.6.3821
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
