The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments
Open accessAbstract
Although recent studies have indicated that the major histocompatibility complex–like, β2-microglobulin–associated CD1 molecules might function to present a novel chemical class of antigens, lipids and glycolipids, to α/β T cells, little is known about the T cell subsets that interact with CD1. A subset of CD1d-autoreactive, natural killer (NK)1.1 receptor–expressing α/β T cells has recently been identified. These cells, which include both CD4−CD8− and CD4+ T cells, preferentially use an invariant Vα14-Jα281 T cell receptor (TCR) α chain paired with a Vβ8 TCR β chain in mice, or the homologous Vα24-JαQ/Vβ11 in humans. This cell subset can explosively release key cytokines such as interleukin (IL)-4 and interferon (IFN)-γ upon TCR engagement and may regulate a variety of infectious and autoimmune conditions. Here, we report the existence of a second subset of CD1d-restricted CD4+ T cells that do not express the NK1.1 receptor or the Vα14 TCR. Like the Vα14+ NK1.1+ T cells, these T cells exhibit a high frequency of autoreactivity to CD1d, use a restricted albeit distinct set of TCR gene families, and contribute to the early burst of IL-4 and IFN-γ induced by intravenous injection of anti-CD3. However, the Vα14+ NK1.1+ and Vα14− NK1.1− T cells differ markedly in their requirements for self-antigen presentation. Antigen presentation to the Vα14+ NK1.1+ cells requires endosomal targeting of CD1d through a tail-encoded tyrosine-based motif, whereas antigen presentation to the Vα14− NK1.1− cells does not. These experiments suggest the existence of two phenotypically different subsets of CD1d-restricted T cells that survey self-antigens loaded in distinct cellular compartments.
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Cites
CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400
MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
Bendelac, A., Rivera, M. N., Park, S.-H., & Roark, J. H. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.535 · Cited by 1,326
Self-citationRequirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M. (1997) · Science · doi:10.1126/science.278.5343.1623 · Cited by 1,237
Lantz, O., & Bendelac, A. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,057
Self-citationRecognition of a lipid antigen by CD1-restricted αβ+ T cells
Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994) · Nature · doi:10.1038/372691a0 · Cited by 978
CD1 Recognition by Mouse NK1 + T Lymphocytes
Bendelac, A., Lantz, O., Quimby, M. E., Yewdell, J. W., Bennink, J. R., & Brutkiewicz, R. R. (1995) · Science · doi:10.1126/science.7538697 · Cited by 914
Self-citationMice lacking MHC class II molecules
Cosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C., & Mathis, D. (1991) · Cell · doi:10.1016/0092-8674(91)90448-8 · Cited by 852
Yoshimoto, T., & Paul, W. E. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1285 · Cited by 841
Porcelli, S., Yockey, C. E., Brenner, M. B., & Balk, S. P. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.1.1 · Cited by 756
CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens
Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., et al. (1995) · Science · doi:10.1126/science.7542404 · Cited by 740
Cited by
Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway
Terabe, M., Matsui, S., Noben-Trauth, N., Chen, H., Watson, C., Donaldson, D. D., Carbone, D. P., Paul, W. E., & Berzofsky, J. A. (2000) · Nature Immunology · doi:10.1038/82771 · Cited by 699
Murine CD1d-Restricted T Cell Recognition of Cellular Lipids
Gumperz, J. E., Roy, C., Makowska, A., Lum, D., Sugita, M., Podrebarac, T., Koezuka, Y., Porcelli, S. A., Cardell, S., Brenner, M. B., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80174-0 · Cited by 469
Dendritic Cells: Immune Regulators in Health and Disease
Lipscomb, M. F., & Masten, B. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00023.2001 · Cited by 465
STEIN-STREILEIN, J., & STREILEIN, J. W. (2002) · International Reviews of Immunology · doi:10.1080/08830180212066 · Cited by 218
Metadata
- Authors
- Chiu, Y.-H., Jayawardena, J., Weiss, A., Lee, D., Park, S.-H., Dautry-Varsat, A., & Bendelac, A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-01-04
- Volume
- 189
- Issue
- 1
- Pages
- 103-110
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2001657366
- Cited by
- 269
- References
- 31
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chiu, Y.-H., Jayawardena, J., Weiss, A., Lee, D., Park, S.-H., Dautry-Varsat, A., & Bendelac, A. (1999). Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.189.1.103
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