The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Interleukin 12–dependent Interferon γ Production by CD8α+Lymphoid Dendritic Cells
Open accessAbstract
We investigated the role of antigen-presenting cells in early interferon (IFN)-γ production in normal and recombinase activating gene 2–deficient (Rag-2−/−) mice in response to Listeria monocytogenes (LM) infection and interleukin (IL)-12 administration. Levels of serum IFN-γ in Rag-2−/− mice were comparable to those of normal mice upon either LM infection or IL-12 injection. Depletion of natural killer (NK) cells by administration of anti-asialoGM1 antibodies had little effect on IFN-γ levels in the sera of Rag-2−/− mice after LM infection or IL-12 injection. Incubation of splenocytes from NK cell–depleted Rag-2−/− mice with LM resulted in the production of IFN-γ that was completely blocked by addition of anti–IL-12 antibodies. Both dendritic cells (DCs) and monocytes purified from splenocytes were capable of producing IFN-γ when cultured in the presence of IL-12. Intracellular immunofluorescence analysis confirmed the IFN-γ production from DCs. It was further shown that IFN-γ was produced predominantly by CD8α+ lymphoid DCs rather than CD8α− myeloid DCs. Collectively, our data indicated that DCs are potent in producing IFN-γ in response to IL-12 produced by bacterial infection and play an important role in innate immunity and subsequent T helper cell type 1 development in vivo.
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Cites
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Cited by
Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion
Castro, F., Cardoso, A. P., Gonçalves, R. M., Serre, K., & Oliveira, M. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00847 · Cited by 1,224
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Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets
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IFN-γ production by antigen-presenting cells: mechanisms emerge
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Self-citation
Metadata
- Authors
- Ohteki, T., Fukao, T., Suzue, K., Maki, C., Ito, M., Nakamura, M., & Koyasu, S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-06-21
- Volume
- 189
- Issue
- 12
- Pages
- 1981-1986
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1893411048
- Cited by
- 332
- References
- 41
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ohteki, T., Fukao, T., Suzue, K., Maki, C., Ito, M., Nakamura, M., & Koyasu, S. (1999). Interleukin 12–dependent Interferon γ Production by CD8α+Lymphoid Dendritic Cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.189.12.1981
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