The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets
Open accessAbstract
Dendritic cells (DC) not only stimulate T cells effectively but are also producers of cytokines that have important immune regulatory functions. In this study we have extended information on the functional differences between DC subpopulations to include differences in the production of the major immune-directing cytokines IL-12, IFN-α, and IFN-γ. Splenic CD4−8+ DC were identified as the major IL-12 producers in response to microbiological or T cell stimuli when compared with splenic CD4−8− or CD4+8− DC; however, all three subsets of DC showed similar IL-12 regulation and responded with increased IL-12 p70 production if IL-4 was present during stimulation. High level CD8 expression also correlated with extent of IL-12 production for DC isolated from thymus and lymph nodes. By using gene knockout mice we ruled out any role for CD8α itself, or of priming by T cells, on the superior IL-12-producing capacity of the CD8+ DC. Additionally, CD8+ DC were identified as the major producers of IFN-α compared with the two CD8− DC subsets, a finding that suggests similarity to the human plasmacytoid DC lineage. In contrast, the CD4−8− DC produced much more IFN-γ than the CD4−8+ or the CD4+8− DC under all conditions tested.
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Cites
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Distinct dendritic cell subsets differentially regulate the class of immune response invivo
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CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen
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Cited by
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Self-citationMerad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Kolumam, G. A., Thomas, S., Thompson, L. J., Sprent, J., & Murali-Krishna, K. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050821 · Cited by 965
Signals required for programming effector and memory development by CD8+ T cells
Mescher, M. F., Curtsinger, J. M., Agarwal, P., Casey, K. A., Gerner, M., Hammerbeck, C. D., Popescu, F., & Xiao, Z. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00382.x · Cited by 601
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells
Luber, C. A., Cox, J., Lauterbach, H., Fancke, B., Selbach, M., Tschopp, J., Akira, S., Wiegand, M., Hochrein, H., O'Keeffe, M., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.013 · Cited by 576
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Metadata
- Authors
- Hochrein, H., Shortman, K., Vremec, D., Scott, B., Hertzog, P., & O’Keeffe, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-05-01
- Volume
- 166
- Issue
- 9
- Pages
- 5448-5455
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2100313593
- Cited by
- 490
- References
- 43
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hochrein, H., Shortman, K., Vremec, D., Scott, B., Hertzog, P., & O’Keeffe, M. (2001). Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.9.5448
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