The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors.
Open accessAbstract
Osteoclasts are terminally differentiated cells derived from hematopoietic stem cells. However, how their precursor cells diverge from macrophagic lineages is not known. We have identified early and late stages of osteoclastogenesis, in which precursor cells sequentially express c-Fms followed by receptor activator of nuclear factor κB (RANK), and have demonstrated that RANK expression in early-stage of precursor cells (c-Fms+RANK−) was stimulated by macrophage colony-stimulating factor (M-CSF). Although M-CSF and RANKL (ligand) induced commitment of late-stage precursor cells (c-Fms+RANK+) into osteoclasts, even late-stage precursors have the potential to differentiate into macrophages without RANKL. Pretreatment of precursors with M-CSF and delayed addition of RANKL showed that timing of RANK expression and subsequent binding of RANKL are critical for osteoclastogenesis. Thus, the RANK–RANKL system determines the osteoclast differentiation of bipotential precursors in the default pathway of macrophagic differentiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Glucocorticoids also stimulate osteoblasts to produce M-CSF (260), which is an important cofactor for osteoclastogenesis (261).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [261]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
Self-citationOPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290
Self-citationYoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Self-citationManolagas, S. C., & Jilka, R. L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320506 · Cited by 1,670
Hsu, H., Lacey, D. L., Dunstan, C. R., Solovyev, I., Colombero, A., Timms, E., Tan, H.-L., Elliott, G., Kelley, M. J., Sarosi, I., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3540 · Cited by 1,636
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint
Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,265
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Roodman, 1996, Advances in bone biologythe osteoclast, Endocr. Rev., 17, 308
Cited by
Sorted by citations
Items 401–500 of 692
Osteoporosis: From osteoscience to neuroscience and beyond
Kwan, P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.02.001 · Cited by 20
Xie, R., Kuijpers‐Jagtman, A. M., & Maltha, J. C. (2008) · Acta Odontologica Scandinavica · doi:10.1080/00016350802317488 · Cited by 20
Lorenzo, J. A., CANALIS, E. M., & Raisz, L. G. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00029-8 · Cited by 20
Cackowski, F. C., & Roodman, G. D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.073 · Cited by 20
Qu, Z., An, H., Feng, M., Huang, W., Wang, D., Zhang, Z., & Yan, L. W. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17467 · Cited by 20
Takemura, K., Sakashita, N., Fujiwara, Y., Komohara, Y., Lei, X., Ohnishi, K., Suzuki, H., Kodama, T., Mizuta, H., & Takeya, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.126 · Cited by 19
Zhao, K., Jia, Y., Peng, J., Pang, C., Zhang, T., Han, W., Jiang, J., Lu, X., Zhu, J., & Qian, Y. (2019) · The FASEB Journal · doi:10.1096/fj.201802575rr · Cited by 20
Chu, B., Chen, S., Zheng, X., Ye, J., Cheng, X., Zhang, L., Guo, D., Wang, P., Hong, D., & Hong, Z. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16055 · Cited by 19
Chen, K., Yuan, Y. J., Wang, Z., Song, D., Zhao, J., Cao, Z., Chen, J., Guo, Q., Chen, L., Tickner, J. C., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27385 · Cited by 20
Yamada, N., Tsujimura, T., Ueda, H., Hayashi, S., Ohyama, H., Okamura, H., & Terada, N. (2005) · Cytokine · doi:10.1016/j.cyto.2005.03.009 · Cited by 19
Human T-Cell Leukemia Virus Type I
Matsuoka, M. (2006) · Elsevier eBooks · doi:10.1016/b978-0-7216-0081-9.50033-9 · Cited by 19
The effects of vasoactive intestinal peptide on RANKL-induced osteoclast formation
Qu, H., Zhuang, Y., Zhu, L., Zhao, Z., & Wang, K. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-7607 · Cited by 18
Xie, R., Kuijpers‐Jagtman, A. M., & Maltha, J. C. (2009) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2008.00588.x · Cited by 18
The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells
Lorenzo, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00009-8 · Cited by 20
Suzuki, T., Katsumata, S.-I., Matsuzaki, H., & Suzuki, K. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-87 · Cited by 18
Disruption of c-Kit Signaling in KitW-sh/W-sh Growing Mice Increases Bone Turnover
Lotinun, S., & Krishnamra, N. (2016) · Scientific Reports · doi:10.1038/srep31515 · Cited by 18
Yang, X., Gao, W., Wang, B., Wang, X., Guo, H., Yuan, X. H., Kong, L., & Hao, D. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26105 · Cited by 19
Pmepa1 induced by RANKL‐p38 MAPK pathway has a novel role in osteoclastogenesis
Funakubo, N., Xu, X., Kukita, T., Nakamura, S., Miyamoto, H., & Kukita, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26147 · Cited by 18
Russo, R., Mallia, S., Zito, F., & Lampiasi, N. (2019) · Cells · doi:10.3390/cells8020131 · Cited by 18
Adapala, N. S., Root, S. H., Lorenzo, J. A., Aguila, H. L., & Sanjay, A. (2019) · Bone Reports · doi:10.1016/j.bonr.2019.100203 · Cited by 18
Rauwel, B., Degboé, Y., Diallo, K., Sayegh, S., Baron, M., Boyer, J., Constantin, A., Cantagrel, A. G., & Davignon, J. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3943 · Cited by 18
Altered Hematopoietic Stem Cell and Osteoclast Precursor Frequency in Cathepsin K Null Mice
Jacome-Galarza, C. E., Soung, D. Y., Adapala, N. S., Pickarski, M., Sanjay, A., Duong, L. T., Lorenzo, J., & Drissi, H. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24801 · Cited by 18
Serum amyloid A inhibits RANKL-induced osteoclast formation
Oh, E., Lee, H. Y., Kim, H. J., Park, Y. J., Seo, J. K., Park, J. S., & Bae, Y. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.83 · Cited by 18
Human scaphoid non‐unions exhibit increased osteoclast activity compared to adjacent cancellous bone
Schira‐Heinen, J., Schulte, M., Döbele, C., Wallner, C., Abraham, S. L., Daigeler, A., Kneser, U., Lehnhardt, M., & Behr, B. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12677 · Cited by 17
Age-related expansion and increased osteoclastogenic potential of myeloid-derived suppressor cells
Li, Z., Zhao, Y., Zhu, C., Katz, J., Michalek, S. M., Li, Y., & Zhang, P. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.07.004 · Cited by 17
Biguetti, C. C., Chandrashekar, B. L., Simionato, G. B., Momesso, N. R., Duarte, M. A. H., Rodrigues, D. C., & Matsumoto, M. A. (2023) · Clinical Oral Investigations · doi:10.1007/s00784-023-05087-y · Cited by 17
Repeke, C. E. P., Cardoso, C. R. D. B., Claudino, M., Silveira, E. M. V., Trombone, A. P. F., Campanelli, A. P., Silva, J. S., Júnior, W. M., & Garlet, G. P. (2012) · Journal of Applied Oral Science · doi:10.1590/s1678-77572012000100020 · Cited by 17
Kitano, M., Ogata, A., Sekiguchi, M., Hamano, T., & Sano, H. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-004-0540-0 · Cited by 17
Caveolin-1 regulates osteoclast differentiation by suppressing cFms degradation
Lee, Y. D., Yoon, S., Ji, E., & Kim, H. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.77 · Cited by 18
Lin, X., Song, F., Zhou, L., Wang, Z., Wei, C., Xu, J., Zhao, J., & Liu, Q. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27495 · Cited by 17
Pang, C., Wen, L., Qin, H., Zhu, B., Lu, X., & Luo, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15404 · Cited by 18
Tran, M. T., Okusha, Y., Feng, Y., Morimatsu, M., Wei, P., Sogawa, C. A., Eguchi, T., Kadowaki, T., Sakai, E., Okamura, H., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249352 · Cited by 17
Osteoclast: Origin and Differentiation
Rubin, J. E., & Greenfield, E. M. (2005) · Springer eBooks · doi:10.1007/1-84628-016-8_1 · Cited by 18
Temporal and Spatial Localization of Osteoclasts in Colonies from Embryonic Stem Cells
Hemmi, H., Okuyama, H., Yamane, T., Nishikawa, S., Nakano, T., Yamazaki, H., Kunisada, T., & Hayashi, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4153 · Cited by 17
The role of Toll-like receptor mediated signalling in the pathogenesis of multiple myeloma
Abdi, J., Engels, F., Garssen, J., & Redegeld, F. A. (2011) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.12.001 · Cited by 16
Lee, B., Jo, S., Kim, S.-M., Cho, M., Park, S., Youn, J., Ji, J. D., & Kim, T. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.09.004 · Cited by 16
Yu, X., Li, K., Wang, Z., Fu, F., Shao, S., Song, F., Zhao, J., Chen, W., Liu, Q., & Xu, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28079 · Cited by 16
Tan, Y., Ke, M., Li, Z., Chen, Y., Zheng, J., Wang, Y., Zhou, X., Huang, G., & Li, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.753240 · Cited by 16
Senba, M., Kawai, K., & Mori, N. (2011) · Leukemia Research and Treatment · doi:10.1155/2012/128617 · Cited by 17
Choudhary, S., Goetjen, A., Estus, T., Jacome-Galarza, C. E., Aguila, H. L., Lorenzo, J. A., & Pilbeam, C. C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.686576 · Cited by 16
Roland, P. B. (2007) · Frontiers in bioscience · doi:10.2741/2728 · Cited by 16
HTLV-1 Infection and Its Associated Diseases
Saito, M., Jain, P., Tsukasaki, K., & Bangham, C. R. M. (2012) · Leukemia Research and Treatment · doi:10.1155/2012/123637 · Cited by 16
Kim, T., Lee, B., Kwon, E., Choi, C. H., Sung, I., Kim, Y.-J., Sohn, J., & Ji, J. D. (2012) · Joint Bone Spine · doi:10.1016/j.jbspin.2012.09.011 · Cited by 16
Wang, R., Wang, H., Mu, J., Yuan, H., Pang, Y., Wang, Y., Du, Y., & Feng, H. (2023) · Journal of Biomedical Research · doi:10.7555/jbr.36.202200266 · Cited by 15
Blümke, A., Ijeoma, E., Simon, J., Wellington, R., Purwaningrum, M., Doulatov, S. R., Leber, E., Scatena, M., & Giachelli, C. M. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03547-6 · Cited by 15
Omar, I., Ram, G. G., Rahat, D., Tabach, Y., Berger, M., & Levaot, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-31428-z · Cited by 15
Park, J., Son, Y., Lee, C. H., Nho, C. W., & Yoo, G. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02914-7 · Cited by 15
Park, H.-J., Gholam-Zadeh, M., Yoon, S.-Y., Suh, J., & Choi, H. (2021) · Antioxidants · doi:10.3390/antiox10040619 · Cited by 16
Inhibition of osteoclastogenesis by RNA interference targeting RANK
Ma, R., Xu, J., Dong, B., Kauther, M. D., Jäger, M., & Wedemeyer, C. (2012) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-13-154 · Cited by 15
Hsiao, H.-B., Wu, J., & Lin, W. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1737-9 · Cited by 15
Martín-Saavedra, F., Crespo, L., Escudero-Duch, C., Saldaña, L., Gómez‐Barrena, E., & Vilaboa, N. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-15036-x · Cited by 15
Kim, E.-J., Lee, H., Kim, M. H., & Yang, W. M. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2331-5 · Cited by 15
RANKL Induces Formation of Avian Osteoclasts from Macrophages but Not from Macrophage Polykaryons
Boissy, P., Destaing, O., & Jurdic, P. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5787 · Cited by 15
Choi, J., Sung, S., Kang, K., Lee, S., Sung, M. K., Park, W.-T., Kim, Y. I., Seo, M., & Lee, G. W. (2023) · Biochemical Genetics · doi:10.1007/s10528-023-10569-5 · Cited by 14
Kang, J., Sim, J.-S., Zheng, T., & Yim, M. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0900-7 · Cited by 14
Yu, A. X., Xiao, J. R., Zhao, S., Kong, X., Kwan, K. K., Zheng, B. Z.-Y., Wu, K. Q., Dong, T. T.-X., & Tsim, K. W. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073540 · Cited by 14
Huang, H., Jiang, W., Hong, K., Cai, J., He, Y., Ma, X., Wu, P., Lang, J., Ma, Y., Huang, C., et al. (2021) · Phytotherapy Research · doi:10.1002/ptr.7088 · Cited by 14
Wang, Q., Chen, D., Wang, Y., Dong, C., Liu, J., Chen, K., Song, F., Wang, C., Yuan, J., Davis, R. A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113622 · Cited by 14
Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells into osteoclasts.
Chakraborty, S., Kloos, B., Roetz, N., Schmidt, S., Eigenbrod, T., Kamitani, S., & Kubatzky, K. F. (2018) · Immunobiology · doi:10.1016/j.imbio.2017.09.001 · Cited by 13
Li, Y., Chen, F., Liu, T., Cai, Z., Chen, K., Tang, G., Huang, J., Liu, X.-G., Huang, J., Wang, P., et al. (2020) · Stem Cells International · doi:10.1155/2020/8829212 · Cited by 14
Kang, H. S., Park, E. K., Kim, K., Park, J. Y., Choi, J., Shin, H., Jun, C., Kang, S., & Kim, S. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)13064-0 · Cited by 14
Kim, J. H., Kim, K., Kim, I., Seong, S., Koh, J., & Kim, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073500 · Cited by 13
Yoshida, S., Ikedo, A., Yanagihara, Y., Sakaue, T., Saeki, N., & Imai, Y. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae015 · Cited by 13
Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts
Kawamata, A., Inoue, A., Miyajima, D., Hemmi, H., Mashima, R., Hayata, T., Ezura, Y., Amagasa, T., Yamanashi, Y., & Noda, M. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22909 · Cited by 13
Zhang, T., Zhao, K., Han, W., Yang, W., Lu, X., Liu, Q., Li, X., & Qian, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27087 · Cited by 13
Extracellular Vesicle-Mediated Bone Remodeling and Bone Metastasis: Implications in Prostate Cancer
Patil, K., & Soekmadji, C. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_12 · Cited by 14
Amano, S., Sekine, K., Bonewald, L. F., & Ohmori, Y. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21827 · Cited by 13
Lee, D., Kim, J. ‐., Choi, S., Cha, J., Bak, E., & Yoo, Y. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12366 · Cited by 13
de Paula, F. J. A., Black, D. M., & Rosen, C. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00029-0 · Cited by 14
Epigenetic mechanisms of myeloid differentiation in the tumor microenvironment
Rodríguez‐Ubreva, J., García-Gómez, A., & Ballestar, E. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.04.008 · Cited by 13
Bae, S., Shin, M. W., Son, T., Lee, H. S., Chae, J. S., Jeon, S., Oh, G. T., & Kim, K. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0201-3 · Cited by 14
Weitzmann, M. N. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-56192-9_12 · Cited by 13
Inhibition of differentiation and function of osteoclasts by dimethyl sulfoxide (DMSO)
Yang, C., Madhu, V., Thomas, C., Yang, X., Du, X., Dighe, A. S., & Cui, Q. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2245-1 · Cited by 13
Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells
Fan, X., Fan, D., Gewant, H. D., Royce, C. L., Nanes, M. S., & Rubin, J. E. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e103 · Cited by 13
Klyucherev, T. O., Peshkova, M., Yurkanova, M. D., Kosheleva, N. V., Svistunov, A. А., Liang, X., & Timashev, P. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125766 · Cited by 12
Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss
Ha, H., Shim, K., Kim, T. S., Lee, C.-J., Park, J. H., Kim, H. S., & Yeul, J. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-352 · Cited by 13
Kitazawa, R., Haraguchi, R., Kohara, Y., & Kitazawa, S. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.07.100 · Cited by 12
Li, G., Sul, O., Yu, R., & Choi, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073697 · Cited by 12
Seta, N., Okazaki, Y., & Kuwana, M. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.4 · Cited by 12
Biomimetic materials for controlling bone cell responses
Drevelle, O. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s378 · Cited by 12
Ceglie, I. D., Blom, A. B., Davar, R., Logie, C., Martens, J. H. A., Habibi, E., Böttcher, L., Roth, J., Vogl, T., Goodyear, C. S., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802691rr · Cited by 12
Vitamin D Inhibition of TRPV5 Expression During Osteoclast Differentiation
Gu, J., Tong, X., Chen, Y., Zhang, C., Ma, T., Li, S., Min, W., Yuan, Y., Liu, X., Bian, J., et al. (2019) · Intern J Endocrinol Metab · doi:10.5812/ijem.91583 · Cited by 12
Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis via suppressing NFATc1 activation
Wang, L., Chen, K., He, J., Kenny, J., Yuan, Y. J., Chen, J., Liu, Q., Tan, R. X., Zhao, J., & Xu, J. (2019) · RSC Advances · doi:10.1039/c9ra07240c · Cited by 12
Wang, L., Qiu, X., Gui, Y., Xu, Y., Gober, H.-J., & Li, D. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s88512 · Cited by 12
Lee, Y., Kim, H. J., Park, C., Kim, W.-S., Lee, Z. H., & Kim, H. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1561 · Cited by 13
CD13 is a critical regulator of cell–cell fusion in osteoclastogenesis
Ghosh, M., Kelava, T., Vrhovac, I., Kalajzić, I., & Shapiro, L. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-90271-x · Cited by 12
Hayashi, S., Tsuneto, M., Yamada, T., Nose, M., Yoshino, M., Shultz, L., & Yamazaki, H. (2004) · Endocrinology · doi:10.1210/en.2004-0172 · Cited by 16
Circulating Osteoclast Precursors: A Mechanism and a Marker of Erosive Arthritis
Xing, L., & Schwarz, E. M. (2005) · Current Rheumatology Reviews · doi:10.2174/1573397052954127 · Cited by 12
Macrophages and osteoclasts: similarity and divergence between bone phagocytes
Halper, J., Dolfi, B., Ivanov, S., Madel, M., & Blin‐Wakkach, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1683872 · Cited by 12
Castro, D. M., Lamana, A., Arribas‐Castaño, P., Gutiérrez‐Cañas, I., Villanueva‐Romero, R., Pérez‐García, S., Martínez, C., Juarranz, Y., de Córdoba‐Oñate, S. F., González‐Álvaro, I., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9121880 · Cited by 11
Osteoimmunology research in rheumatoid arthritis: From single-cell omics approach
Hu, N., Wang, J., Ju, B., Li, Y., Fan, P., Jin, X., Kang, X., & Wu, S. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002678 · Cited by 11
NDR2 is critical for osteoclastogenesis by regulating ULK1-mediated mitophagy
Kong, X., Shan, Z., Zhao, Y., Tao, S., Chen, J., Ji, Z., Jin, J., Liu, J., Lin, W., Wang, X.-J., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.180409 · Cited by 11
Takami, K., Okamoto, K., Etani, Y., Hirao, M., Miyama, A., Okamura, G., Goshima, A., Miura, T., Kurihara, T., Fukuda, Y., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.171962 · Cited by 11
Guo, H., Zhang, J., HAO, S., & Jin, Q. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1416 · Cited by 11
Lafferty, M., Fantry, L., Bryant, J., Jones, O. D., Hammoud, D., Weitzmann, M., Lewis, G., Garzino-Demo, A., & Reid, W. (2014) · Pathogens and Disease · doi:10.1111/2049-632x.12117 · Cited by 12
Human mesenchymal tumour-associated macrophages differentiate into osteoclastic bone-resorbing cells
Yang, T.-M., Sabokbar, A., Gibbons, C. L. M. H., & Athanasou, N. A. (2002) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.84b3.0840452 · Cited by 11
Cytotoxic Signal Transmission Pathways via TNF Family Receptors
Петрович, Б. И., Moshnikova, A., & Prusakova, O. V. (2002) · Biochemistry (Moscow) · doi:10.1023/a:1014884400144 · Cited by 11
Wu, H. C., Yin, G., Pu, X., Wang, J., Liao, X., & Huang, Z. (2021) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0325 · Cited by 10
The Role of Jak/STAT Pathways in Osteoclast Differentiation
Lee, Y., & Kim, H. H. (2011) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2011.19.2.141 · Cited by 10
Fuji, H., Ohmae, S., Noma, N., Takeiri, M., Yasutomi, H., Izumi, K., Ito, M., Toyomoto, M., Iwaki, S., Takemoto, K., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.153 · Cited by 10
Metadata
- Authors
- Arai, F., Miyamoto, T., Ohneda, O., Inada, T., Sudo, T., Brasel, K., Miyata, T., Anderson, D. M., & Suda, T.
- Affiliations
- Meikai University (JP)
- Institute of Molecular Embryology and Genetics, Kumamoto University (JP)
- Toray Industries, Inc. (Japan) (JP)
- dDepartment of Molecular Biology, Immunex Corporation, Seattle, Washington 98101-2936
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-12-20
- Volume
- 190
- Issue
- 12
- Pages
- 1741-1754
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2195707
- OpenAlex
- W2132408993
- Cited by
- 693
- References
- 54
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 20 · 2023: 33 · 2022: 33 · 2021: 32 · 2020: 42 · 2019: 38 · 2018: 31 · 2017: 31 · 2016: 30 · 2015: 40 · 2014: 34 · 2013: 31 · 2012: 38
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- osteoclastogenesis, osteoclast precursor cells, c-fms, RANK, RANKL, macrophage colony-stimulating factor, macrophage differentiation, lineage commitment, hematopoietic stem cells
- MeSH terms
- Animals, Carrier Proteins, Cell Differentiation, Hematopoietic Stem Cells, Ligands, Macrophages, Membrane Glycoproteins, Mice, Inbred C57BL, Osteoclasts, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor, Receptors, Tumor Necrosis Factor, Cell Lineage, Mice, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review