Suda, Toshio

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine

Hematopoietic Stem Cell TransplantationRedox biology and oxidative stress

Cited by 1,362

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 1,175

Metabolic requirements for the maintenance of self-renewing stem cells

Ito, K., & Suda, T. (2014) · Nature Reviews Molecular Cell Biology

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 1,014

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 891

DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells

Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., et al. (2005) · The Journal of Experimental Medicine

Bone Metabolism and DiseasesPhagocytosis and Immune Regulation

Cited by 890

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

Suda, T., Takubo, K., & Semenza, G. L. (2011) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 844

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism

Bone Metabolism and DiseasesAxon Guidance and Neuronal Signaling

Cited by 777

Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors.

Arai, F., Miyamoto, T., Ohneda, O., Inada, T., Sudo, T., Brasel, K., Miyata, T., Anderson, D. M., & Suda, T. (1999) · The Journal of Experimental Medicine

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 693

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S.-I., Juang, Y.-C., O’Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., et al. (2010) · Nature

Ubiquitin and proteasome pathwaysDNA Repair Mechanisms

Cited by 357

Angiogenic Role of LYVE-1–Positive Macrophages in Adipose Tissue

Cho, C.-H., Jun Koh, Y., Han, J., Sung, H.-K., Jong Lee, H., Morisada, T., Schwendener, R. A., Brekken, R. A., Kang, G., Oike, Y., et al. (2007) · Circulation Research

Angiogenesis and VEGF in CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 309

p57Kip2 and p27Kip1 Cooperate to Maintain Hematopoietic Stem Cell Quiescence through Interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I., & Suda, T. (2011) · Cell stem cell

Hematopoietic Stem Cell TransplantationHeat shock proteins research

Cited by 289

Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo

Uchiba, M., Okajima, K., Oike, Y., Ito, Y., Fukudome, K., Isobe, H., & Suda, T. (2004) · Circulation Research

Blood Coagulation and Thrombosis MechanismsAngiogenesis and VEGF in Cancer

Cited by 162

Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis

Oike, Y., Yasunaga, K., & Suda, T. (2004) · International Journal of Hematology

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 160

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T., & Kubota, Y. (2012) · Nature Medicine

Angiogenesis and VEGF in CancerRedox biology and oxidative stress

Cited by 152

C/EBPβ and GATA-1 Synergistically Regulate Activity of the Eosinophil Granule Major Basic Protein Promoter: Implication for C/EBPβ Activity in Eosinophil Gene Expression

Yamaguchi, Y., Nishio, H., Kishi, K., Ackerman, S. J., & Suda, T. (1999) · Blood

Asthma and respiratory diseasesGenomics and Chromatin Dynamics

Cited by 65

Mechanisms of Transcription in Eosinophils: GATA-1, but not GATA-2, Transactivates the Promoter of the Eosinophil Granule Major Basic Protein Gene

Yamaguchi, Y., Ackerman, S. J., Minegishi, N., Takiguchi, M., Yamamoto, M., & Suda, T. (1998) · Blood

Genomics and Chromatin DynamicsAsthma and respiratory diseases

Cited by 64

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes

Sera, Y., Nakata, Y., Ueda, T., Yamasaki, N., Koide, S., Kobayashi, H., Ikeda, K.-I., Kobatake, K., Iwasaki, M., Oda, H., et al. (2021) · Blood

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 42

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., et al. (2007) · Cell stem cell

Hematopoietic Stem Cell TransplantationFOXO transcription factor regulation

Cited by 41

Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation

Shima, H., Takubo, K., Tago, N., Iwasaki, H., Arai, F., Takahashi, T., & Suda, T. (2010) · Experimental Hematology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 35

Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal

Arai, F., Stumpf, P. S., Ikushima, Y. M., Hosokawa, K., Roch, A., Lutolf, M. P., Suda, T., & MacArthur, B. D. (2020) · Cell Systems

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 19