CoChat
Sign Up
Cited by 334Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune responses and vaccinations

TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo

Open access
Josien, Régis, Li, Hong-Li, Ingulli, Elizabeth, Sarma, Supria, R.Wong, Brian, Vologodskaia, Maria, Steinman, Ralph M., Choi, Yongwon·2000·The Journal of Experimental Medicine
DOI 10.1084/jem.191.3.495PMC PMC2195824
Open this paper in CoChat — free accountOpen PDF

Abstract

Mature dendritic cells (DCs) are powerful antigen presenting cells that have the unique capacity to migrate to the T cell zone of draining lymph nodes after subcutaneous injection. Here we report that treatment of antigen-pulsed mature DCs with tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE), a TNF family member, before immunization enhances their adjuvant capacity and elicits improved T cell priming in vivo, such that both primary and memory T cell immune responses are enhanced. By enumerating migratory DCs in the draining lymph nodes and by studying their function in stimulating naive T cells, we show that one of the underlying mechanisms for enhanced T cell responses is an increase in the number of ex vivo antigen-pulsed DCs that are found in the T cell areas of lymph nodes. These results suggest that the longevity and abundance of mature DCs at the site of T cell priming influence the strength of the DC-initiated T cell immunity in situ. Our findings have the potential to improve DC-based immunotherapy; i.e., the active immunization of humans with autologous DCs that have been pulsed with clinically significant antigens ex vivo.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1084/jem.191.3.495

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • RANK activation of Langerhans cells by UV can induce pro-survival and anti-apoptotic signals due to upregulation of Bcl-xL, leading to generation of regulatory T cells.

    “Intriguingly, receptor activator of NF-κB (RANK) activation of LCs by UV can induce the pro-survival and anti-apoptotic signals due to the upregulation of Bcl-xL, leading to the generation of regulatory T cells.”

    From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [69]

    The Introduction (page unavailable) says TRANCE promotes survival of mature dendritic cells, most likely by upregulating Bcl-XL. The paper does not establish that UV activates RANK in Langerhans cells or that this pathway generates regulatory T cells; it instead examines TRANCE-treated dendritic cells and antigen-specific T-cell responses. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • A well-characterized consequence of RANK activation on Langerhans cells is an anti-apoptotic signal caused by the upregulation of Bcl-xL.

    “A well-characterized consequence of RANK activation on LCs is an anti-apoptotic signal caused by the upregulation of Bcl-xL [67–69].”

    From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [69]

    The Introduction (page unavailable) says TRANCE promotes survival of mature dendritic cells, most likely by upregulating Bcl-XL. It does not establish this mechanism specifically in Langerhans cells, and its mechanistic wording is less certain than the claim’s “caused by.” (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

No references could be resolved yet.

Research works printed but not linked: 33

  1. Hart D.N. Dendritic cellsunique leukocyte populations which control the primary immune response Blood. 90 1997 3245 3287 9345009
  2. Banchereau J. Steinman R.M. Dendritic cells and the control of immunity Nature. 392 1998 245 252 9521319
  3. Inaba K. Metlay J.P. Crowley M.T. Steinman R.M. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ J. Exp. Med. 172 1990 631 640 2373994 PMC2188342
  4. Kupiec-Weglinski J.W. Austyn J.M. Morris P.J. Migration patterns of dendritic cells in the mousetraffic from the blood, and T cell–dependent and –independent entry to lymphoid tissues J. Exp. Med. 167 1988 632 645 3258009 PMC2188851
  5. Ingulli E. Mondino A. Khoruts A. Jenkins M.K. In vivo detection of dendritic cell antigen presentation to CD4+ T cells J. Exp. Med. 185 1997 2133 2141 9182685 PMC2196354
  6. Fossum S. Lymph-borne dendritic leukocytes do not recirculate, but enter the lymph node paracortex to become interdigitating cells Scand. J. Immunol 27 1988 97 105 3340823
  7. Pugh C.W. MacPherson G.G. Steer H.W. Characterization of nonlymphoid cells derived from rat peripheral lymph J. Exp. Med. 157 1983 1758 1779 6854208 PMC2187049
  8. Wong B.R. Josien R. Lee S.Y. Sauter B. Li H.-L. Steinman R.M. Choi Y. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell–specific survival factor J. Exp. Med. 186 1997 2075 2080 9396779 PMC2199171
  9. Wong B.R. Rho J. Arron J.R. Robinson E. Orlinick J. Chao M. Kalachikov S. Cayani E. Bartlett F.S. III Frankel W.N. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells J. Biol. Chem. 272 1997 25190 25194 9312132
  10. Wong B.R. Josien R. Choi Y. TRANCE is a TNF family member that regulates dendritic cell and osteoclast function J. Leukoc. Biol. 65 1999 715 724 10380891
  11. Josien R. Wong B.R. Li H.L. Steinman R.M. Choi Y. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells J. Immunol. 162 1999 2562 2568 10072496
  12. Anderson D.M. Maraskovsky E. Billingsley W.L. Dougall W.C. Tometsko M.E. Roux E.R. Teepe M.C. DuBose R.F. Cosman D. Galibert L.A. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function Nature. 390 1997 175 179 9367155
  13. Bachmann M.F. Wong B.R. Josien R. Steinman R.M. Oxenius A. Choi Y. TRANCE, a tumor necrosis factor family member critical for CD40 ligand–independent T helper cell activation J. Exp. Med. 189 1999 1025 1031 10190893 PMC2193017
  14. Inaba K. Inaba M. Naito M. Steinman R.M. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guérin organisms, and sensitize mice to mycobacterial antigens in vivo J. Exp. Med. 178 1993 479 488 7688024 PMC2191128
  15. Inaba K. Inaba M. Romani N. Aya H. Deguchi M. Ikehara S. Muramatsu S. Steinman R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor J. Exp. Med. 176 1992 1693 1702 1460426 PMC2119469
  16. Pierre P. Turley S.J. Gatti E. Hull M. Meltzer J. Mirza A. Inaba K. Steinman R.M. Mellman I. Developmental regulation of MHC class II transport in mouse dendritic cells Nature. 388 1997 787 792 9285592
  17. Inaba K. Pack M. Inaba M. Sakuta H. Isdell F. Steinman R.M. High levels of a major histocompatibility complex II–self peptide complex on dendritic cells from the T cell areas of lymph nodes J. Exp. Med. 186 1997 665 672 9271582 PMC2199017
  18. Metlay J.P. Witmer-Pack M.D. Agger R. Crowley M.T. Lawless D. Steinman R.M. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies J. Exp. Med. 171 1980 1753 1772 2185332 PMC2187889
  19. Witmer-Pack M.D. Crowley M.T. Inaba K. Steinman R.M. Macrophages, but not dendritic cells, accumulate colloidal carbon following administration in situ J. Cell Sci. 105 1993 965 973 7693737
  20. Murphy K.M. Heimberger A.B. Loh D.Y. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo Science. 250 1990 1720 1723 2125367
  21. Zhang X. Sun S. Hwang I. Tough D.F. Sprent J. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15 Immunity. 8 1998 591 599 9620680
  22. Macatonia S.E. Hosken N.A. Litton M. Vieira P. Hsieh C.S. Culpepper J.A. Wysocka M. Trinchieri G. Murphy K.M. O'Garra A. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells J. Immunol. 154 1995 5071 5079 7730613
  23. Yanagihara S. Komura E. Nagafune J. Watarai H. Yamaguchi Y. EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation J. Immunol. 161 1998 3096 3102 9743376
  24. Sallusto F. Schaerli P. Loetscher P. Schaniel C. Lenig D. Mackay C.R. Qin S. Lanzavecchia A. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation Eur. J. Immunol. 28 1998 2760 2769 9754563
  25. Lanzavecchia A. Lezzi G. Viola A. From TCR engagement to T cell activationa kinetic view of T cell behavior Cell. 96 1999 1 4 9989490
  26. Mackey M.F. Gunn J.R. Maliszewsky C. Kikutani H. Noelle R.J. Barth R.J. Jr. Dendritic cells require maturation via CD40 to generate protective antitumor immunity J. Immunol. 161 1998 2094 2098 9725199
  27. Ridge J.P. Di Rosa F. Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer Nature. 393 1998 474 478 9624003
  28. Schoenberger S.P. Toes R.E. van der Voort E.I. Offringa R. Melief C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions Nature. 393 1998 480 483 9624005
  29. Bennett S.R. Carbone F.R. Karamalis F. Flavell R.A. Miller J.F. Heath W.R. Help for cytotoxic-T-cell responses is mediated by CD40 signalling Nature. 393 1998 478 480 9624004
  30. Fernandez N. Duffour M.T. Perricaudet M. Lotze M.T. Tursz T. Zitvogel L. Active specific T-cell–based immunotherapy for cancernucleic acids, peptides, whole native proteins, recombinant viruses, with dendritic cell adjuvants or whole tumor cell-based vaccines. Principles and future prospects Cytokines Cell. Mol. Ther. 4 1998 53 65 9557217
  31. Schuler G. Steinman R.M. Dendritic cells as adjuvants for immune-mediated resistance to tumors J. Exp. Med. 186 1997 1183 1187 9379142 PMC2199101
  32. Dhodapkar M.V. Steinman R.M. Sapp M. Desai H. Fossella C. Krasovsky J. Donahoe S.M. Dunbar P.R. Cerundolo V. Nixon D.F. Bhardwaj N. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells J. Clin. Invest. 104 1999 173 180 10411546 PMC408478
  33. Morse M.A. Coleman R.E. Akabani G. Niehaus N. Coleman D. Lyerly H.K. Migration of human dendritic cells after injection in patients with metastatic malignancies Cancer Res. 59 1999 56 58 9892184

Cited by

Sorted by citations

Authors
Josien, R., Li, H.-L., Ingulli, E., Sarma, S., R.Wong, B., Vologodskaia, M., Steinman, R. M., & Choi, Y.
Affiliations
  • Rockefeller University (US)
  • aFrom the Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021
  • University of Minnesota (US)
  • Howard Hughes Medical Institute (US)
ORCID
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2000-02-07
Volume
191
Issue
3
Pages
495-502
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.191.3.495
PMC
PMC2195824
OpenAlex
W2106433656
Cited by
334
References
0
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 9 · 2014: 7 · 2013: 9 · 2012: 7
FWCI
12.41
Type
journal article
Language
en
Open access
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (R01AI013013, AI13013, R01AI044264, AI44264)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK39672)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
trance, CCL17, dendritic cells, tumor necrosis factor family, adjuvant effect, T cell priming, memory T cells, dendritic cell migration, draining lymph nodes, antigen-pulsed dendritic cells, DC-based immunotherapy, T cell immunity
MeSH terms
Adjuvants, Immunologic, Animals, Carrier Proteins, Cell Count, Cells, Cultured, Dendritic Cells, Fluoresceins, Fluorescent Dyes, Immunization, Lymph Nodes, Lymphocyte Activation, Membrane Glycoproteins, T-Lymphocytes, Time Factors, Tuberculin, Tumor Necrosis Factor-alpha, Granulocyte-Macrophage Colony-Stimulating Factor, Cytokines, CD40 Ligand, Mice, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review