The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Defective Gp130-Mediated Signal Transducer and Activator of Transcription (Stat) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation
Open accessAbstract
The receptor subunit gp130 transduces multiple cell type–specific activities of the leukemia inhibitory factor (LIF)/interleukin (IL)-6 family of cytokines through the signal transducer and activator of transcription (STAT) and src homology 2 domain–bearing protein tyrosine phosphatase (SHP)-2/ras/Erk pathways. To define STAT-dependent physiological responses, we generated mice with a COOH-terminal gp130ΔSTAT “knock-in” mutation which deleted all STAT-binding sites. gp130ΔSTAT mice phenocopyed mice deficient for IL-6 (impaired humoral and mucosal immune and hepatic acute phase responses) and LIF (failure of blastocyst implantation). However, unlike mice with null mutations in any of the components in the gp130 signaling pathway, gp130ΔSTAT mice also displayed gastrointestinal ulceration and a severe joint disease with features of chronic synovitis, cartilaginous metaplasia, and degradation of the articular cartilage. Mitogenic hyperresponsiveness of synovial cells to the LIF/IL-6 family of cyto-kines was caused by sustained gp130-mediated SHP-2/ras/Erk activation due to impaired STAT-mediated induction of suppressor of cytokine signaling (SOCS) proteins which normally limits gp130 signaling. Therefore, the joint pathology in gp130ΔSTAT mice is likely to arise from the disturbance of the otherwise balanced activation of the SHP-2/ras/Erk and STAT signaling cascades emanating from gp130.
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“Similarly, defective STAT3 activation enhances SHP-2–ERK–MAPK activation pathways, most likely through an impaired STAT3-mediated induction of suppressor of cytokine signaling 3 (SOCS3) (111, 112).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [111]
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Cites
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
Self-citationBlastocyst implantation depends on maternal expression of leukaemia inhibitory factor
Stewart, C. L., Kašpar, P., Brunet, L. J., Bhatt, H., Gadi, I. K., Köntgen, F., & Abbondanzo, S. J. (1992) · Nature · doi:10.1038/359076a0 · Cited by 2,033
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.
Dalton, D., Pitts-Meek, S., Keshav, S., Figari, I., Bradley, A., & Stewart, T. (1993) · Science · doi:10.1126/science.8456300 · Cited by 2,015
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 4×
“Since the phenotype of gp130FxxQ/FxxQ mice is somewhat reminiscent of that observed in LIF-R / (10) and CNTF-R / mice (36), but entirely different to that associated with IL-6 / (4, 5) or IL-11R 1 / mice (8, 9), signaling through the heterodimeric LIF-R /gp130 rather than through homodimeric gp130 appears critical aft…”
BackgroundInfluentialSelf-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.Preprint
Niwa, H., Burdon, T., Chambers, I., & Smith, A. G. (1998) · Genes & Development · doi:10.1101/gad.12.13.2048 · Cited by 1,673
Kelley, W. N. (1985) · Virtual Defense Library (Ministerio de Defensa) · Cited by 1,641
gp 130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES
Taga, T., & Kishimoto, T. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.797 · Cited by 1,468
Structure and function of a new STAT-induced STAT inhibitor
Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997) · Nature · doi:10.1038/43219 · Cited by 1,040
Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., & Yancopoulos, G. D. (1995) · Science · doi:10.1126/science.7871433 · Cited by 979
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- Waring, 1997, Leukemia inhibitory factor, 467
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Items 201–228 of 228
Lauber, S. (2012) · MacSphere (McMaster University) · doi:10.71548/15037 · Cited by 2
Starr, R., & Hilton, D. J. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_5 · Cited by 1
(2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/978160805372811201010003 · Cited by 1
STAT/SOCS Family Members in Inflammation and Diseases
Yoshimura, A., Kinjyo, I., Inagaki‐Ohara, K., & Hanada, T. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_34 · Cited by 1
Pagidas, K., & Norwitz, E. R. (2017) · Cambridge University Press eBooks · doi:10.1017/9781139976787.005 · Cited by 1
Leukemia Inhibitory Factor (LIF) Modulation: a Novel, Non-Hormonal Contraceptive Method
Dolin, H. (2020) · McGill Science Undergraduate Research Journal · doi:10.26443/msurj.v15i1.13 · Cited by 1
Mechanisms and Biological Roles of STAT Activation by the IL-6 Family of Cytokines
Kamimura, D., & Hirano, T. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_11 · Cited by 1
Post-translational Modifications in Regulation of Jak-stat Pathway
Ungureanu, D. (2005) · Tampere University Institutional Repository (Tampere University) · Cited by 1
Signal Transducer and Activator of Transcription 3 (STAT3) and Trophoblast Invasion
Js, F., Poehlmann, T. G., Suman, P., Sk, G., Schleußner, E., & Markert, U. R. (2007) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Negative Regulator of Cytokine Signaling (SOCS) Genes in Inflammation
Yasukawa, H., Kinjyo, I., & Yoshimura, A. (2003) · Developments in cardiovascular medicine · doi:10.1007/978-1-4419-9264-2_3
O’Donoghue, R. J. J., Anderson, G. P., Bozinovski, S., Jones, J. E. C., Ernst, M., Knight, D. A., & Mutsaers, S. E. (2005) · Inflammation Research · doi:10.1007/bf03354054
Self-citation[Interosseous muscles of the rat].
DENİZ, E. (1971) · PubMed
The regulation of gp130 surface expression on monocytes : implications in chronic inflammation
Honke, N., Idm, P., Fischer, R., & Tenbrock, K. (2014) · RWTH Publications (RWTH Aachen)
Molecular signalling in embryo–uterine interactions during implantation
Dey, S. K., & Tranguch, S. L. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545207.014
Sasson, I. E., & Norwitz, E. R. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777851.020
Moffett, A., Loke, C., & McLaren, A. L. D. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545207.013
Transgenic models of uterine biology
Bagchi, I. C., & Bagchi, M. K. (2008) · CRC Press eBooks · doi:10.3109/9780203091500-16
Forde, N., & Simintiras, C. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65739-2
Gnotobiotics and Inflammatory Bowel Disease
Schoeb, T. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804561-9.00008-6
Scatizzi, J. C., & Perlman, H. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3285-4.10020-8
Transgenic models of uterine biology
Bagchi, I. C., & Bagchi, M. K. (2008) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9780203091500.011
Polenov, N. I., Yarmolinskaya, M. I., Zakuraeva, K. А., Krutikova, V. Y., Potapova, E., Kogan, I. Y., & Shengelia, N. D. (2023) · Journal of obstetrics and women s diseases · doi:10.17816/jowd120126
Degenerative joint disease following defective cytokine receptor signaling
Cron, R. Q. (2001) · Arthritis Research & Therapy · doi:10.1186/ar-2001-70552
Alternative Splicing in Embryo Implantation
Yu, L., Zhu, S., Bao, H., & Kong, S. (2025) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000272
Luo, X. W., Luo, D., Liu, C., Zhang, H., Long, M., Cao, S., & Liu, Y. (2025) · Medicine · doi:10.1097/md.0000000000045093
Cellules placentaires et infection par coxiella burnetii
Amara, A. B. (2011) · theses.fr (ABES) · doi:10.70675/560a05fczbfbbz4e49zaf9az4c7610eb46e7
An Update Comprehensive Review on Epigenetic Modifications and Therapies in Autoimmune Diseases
Chen, H., Zhou, S., Ji, F., Chen, K., Jian, L., Wang, Y., Yao, H., Yang, M., & Wu, H. (2026) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-026-09133-x
Zhao, H., Zou, Z., & Yang, Y. (2026) · Biology of Reproduction · doi:10.1093/biolre/ioag202
Metadata
- Authors
- Ernst, M., Inglese, M., Waring, P., Campbell, I. K., Bao, S., Clay, F. J., Alexander, W. S., Wicks, I. P., Tarlinton, D. M., Novak, U., Heath, J. K., & Dunn, A. R.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- The University of Sydney (AU)
- The University of Melbourne (AU)
- ORCID
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-07-16
- Volume
- 194
- Issue
- 2
- Pages
- 189-204
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2193459
- OpenAlex
- W2125415295
- Cited by
- 227
- References
- 51
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 1 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 12 · 2012: 6
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- gp130, STAT signaling, interleukin-6, suppressor of cytokine signaling, articular cartilage degeneration, synovitis, gastrointestinal ulceration, embryo implantation, cytokine receptor signaling, knock-in mice
- MeSH terms
- Suppressor of Cytokine Signaling 1 Protein, Animals, Carrier Proteins, DNA-Binding Proteins, Female, Joint Diseases, Male, Membrane Glycoproteins, Mice, Mutant Strains, Embryo Implantation, Peptic Ulcer, Pregnancy, Repressor Proteins, Signal Transduction, Trans-Activators, Antigens, CD, DNA Primers, Mice, Knockout, Mitogen-Activated Protein Kinases, STAT1 Transcription Factor, STAT3 Transcription Factor, Cytokine Receptor gp130, Suppressor of Cytokine Signaling Proteins, Mice
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