Defective Gp130-Mediated Signal Transducer and Activator of Transcription (Stat) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation
Ernst, Matthias, Inglese, Melissa, Waring, Paul, Campbell, Ian K., Bao, Shisan, Clay, Fiona J., Alexander, Warren S., Wicks, Ian P., Tarlinton, David M., Novak, Ulrike, Heath, Joan K., Dunn, Ashley R.·2001·The Journal of Experimental Medicine
Cited by (228)
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- Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligationIsao Nozaki, John G. Lunz, Susan M. Specht, Donna Beer Stolz, Kenichi Taguchi, Vladimir M. Subbotin, Noriko Murase, Anthony Jake Demetris · 2004 · Laboratory Investigation
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- TNF-α Induces Tyrosine Phosphorylation and Recruitment of the Src Homology Protein-Tyrosine Phosphatase 2 to the gp130 Signal-Transducing Subunit of the IL-6 Receptor ComplexJohannes Georg Bode, Jens Schweigart, Jan Kehrmann, Christian Ehlting, Fred Schaper, Peter Claus Heinrich, Dieter Häussinger · 2003 · The Journal of Immunology
- Molecular dissection of gp130-dependent pathways in hepatocytes during liver regenerationDierssen, Uta, Beraza, Naiara, Lutz, Holger H., Liedtke, Christian, Ernst, Matthias, Wasmuth, Hermann E., Trautwein, Christian · 2008 · Journal of Biological Chemistry
- Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behaviorMaría Erta, Mercedes Giralt, Flavia Lorena Esposito, Olaya Fernández‐Gayol, Juan Hidalgo · 2015 · Hormones and Behavior
- Differential expression and activation of Stat3 during mouse embryo implantation and decidualizationChun‐Bo Teng, Honglu Diao, Xinghong Ma, Li‐Bin Xu, Zeng‐Ming Yang · 2004 · Molecular Reproduction and Development
- Regulation and Function of Trefoil Factor Family 3 Expression in the Biliary TreeIsao Nozaki, John G. Lunz, Susan M. Specht, Jong‐In Park, Andrew S. Giraud, Noriko Murase, Anthony Jake Demetris · 2004 · American Journal Of Pathology
- gp130 signaling in bone cell biology: Multiple roles revealed by analysis of genetically altered miceNatalie A. Sims · 2008 · Molecular and Cellular Endocrinology
- Negative regulation of cytokine signaling and inflammatory diseasesK Inagaki-Ohara · 2003 · Current Opinion in Pharmacology
- Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms ExpressionJenkins, Brendan J., Grail, Dianne, Inglese, Melissa, Quilici, Cathy, Bozinovski, Steven, Wong, Peter, Ernst, Matthias · 2004 · Molecular and Cellular Biology
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- Progesterone Regulation of the Mammalian Ortholog of Methylcitrate Dehydratase (Immune Response Gene 1) in the Uterine Epithelium during Implantation through the Protein Kinase C PathwayBo Chen, Damin Zhang, Jeffrey W. Pollard · 2003 · Molecular Endocrinology
- The immediate early genes Fos and Egr1 become STAT1 transcriptional targets in the absence of STAT3Davide Schiavone, Lidia Avalle, Sarah Dewilde, Valeria Poli · 2011 · FEBS Letters
- Histopathological and immunological changes induced by magnetite nanoparticles in the spleen, liver and genital tract of mice following intravaginal instillationAziz Awaad · 2015 · The Journal of Basic and Applied Zoology
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- Minimal role for STAT1 in interleukin‐6 signaling and actions in the murine brainElisenda Sanz, Markus J. Hofer, Mercedes Unzeta, Iain Leslie Campbell · 2007 · Glia
- An update on the pathogenic role of IL-6 in rheumatic diseasesYuko Kaneko, Tsutomu Takeuchi · 2021 · Cytokine
- Monoclonal anti-leukemia inhibitory factor antibody inhibits blastocyst implantation in the rhesus monkeyJayasree Sengupta, Parameswaran Grace Lalitkumar, Najwa Abdur Rashid, Debabrata Ghosh · 2006 · Contraception
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- STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced ColitisLokman Pang, Jennifer Huynh, Mariah Alorro, Xia Li, Matthias Ernst, Ashwini L. Chand · 2021 · Biomedicines
- Mechanisms Underlying Bone Loss Associated with Gut InflammationKe Ke, Manoj Arra, Yousef Abu‐Amer · 2019 · International Journal of Molecular Sciences
- Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1.Ze-junTIAN, WeiCui, Yong-junLI, Yu-mingHAO, JunDU, FanLIU, HuiZhang, Xiu-guangZU, Su-yunLIU, Li Chen et al. · 2004 · PubMed
- Effect of single post-ovulatory administration of levonorgestrel on gene expression profile during the receptive period of the human endometriumManuel Frías Vargas, Alejandro Tapia-Pizarro, Soledad Henríquez, M Quezada, A.M. Salvatierra, Noé G, David J. Munroe, Luís Velásquez, H.B. Croxatto · 2011 · Journal of Molecular Endocrinology
- Identification of the Leukemia Inhibitory Factor Cell Targets Within the Rat TestisIsabelle Dorval, Jean‐Guy Delcros, Harri H. Hakovirta, Jorma Toppari, Bernard Jégou, Claire Piquet‐Pellorce · 2004 · Biology of Reproduction
- SOCS3 negatively regulates LIF signaling in neural precursor cellsEmery, B., Merson, T.D., Snell, C., Young, K.M., Ernst, M., Kilpatrick, T.J. · 2006 · Molecular and Cellular Neuroscience
- Identification of Sites of STAT3 Action in the Female Reproductive Tract through Conditional Gene DeletionRebecca L. Robker, Laura N. Watson, Sarah Anne Robertson, Kylie R. Dunning, Eileen A. McLaughlin, Darryl Lyndon Russell · 2014 · PLoS ONE
- Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in MiceChunxiao Wang, Yong Song, Xin Wang, Ruijun Mao, Lijun Song · 2018 · Medical Science Monitor
- Temporal expression profiling of the uterine luminal epithelium of the pseudo-pregnant mouse suggests receptivity to the fertilized egg is associated with complex transcriptional changesE.A. Campbell, Laura O’Hara, Rob D. Catalano, Andrew Sharkey, Tom C. Freeman, Martin H. Johnson · 2006 · Human Reproduction
- The Role of Steroid Hormone Receptors in the Establishment of Pregnancy in RodentsNyssa R. Adams, Francesco John DeMayo · 2015 · Advances in anatomy, embryology and cell biology
- Pleiotropy and Redundancy of STAT Proteins in Early PregnancyTomasz Maj, Anna Chełmońska‐Soyta · 2007 · Reproduction in Domestic Animals
- Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signalingBrendan John Jenkins, Cathy Quilici, Andrew Warwick Roberts, Dianne Grail, Ashley R. Dunn, Matthias Ernst · 2002 · Experimental Hematology
- Signal transducer and activator of transcription 3 (Stat3) expression and activation in rat uterus during early pregnancyChun‐Bo Teng, Honglu Diao, Hong Ma, Jing Cong, Hao Yu, Xinghong Ma, Libin Xu, Zeng‐Ming Yang · 2004 · Reproduction
- From Bound Cells Comes a Sound Mind: The Role of Neuronal Growth Regulator 1 in Psychiatric DisordersKyungchul Noh, Jung-Cheol Park, Jung‐Soo Han, Sung Joong Lee · 2020 · Experimental Neurobiology
- Immunohistochemical localization of leukemia inhibitory factor, interleukins 1 and 6 at the primary implantation site in the rhesus monkeyJayasree Sengupta, Latika Dhawan, Debabrata Ghosh · 2003 · Cytokine
- Joint disease caused by defective gp130-mediated STAT signalingTetsuji Naka, Tadamitsu Kishimoto · 2002 · Arthritis Research & Therapy
- Interleukin 1 beta is induced by interleukin 11 during decidualization of human endometrial stromal cells, but is not released in a bioactive formChristine A. White, Evdokia Dimitriadis, Andrew Sharkey, Chelsea J. Stoikos, Lois A. Salamonsen · 2006 · Journal of Reproductive Immunology
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- Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed ratsMohd Fahami Nur Azlina, Hj Mohd Saad Qodriyah, Kien Hui Chua, Yusof Kamisah · 2017 · World Journal of Gastroenterology
- Target-oriented anti-implantation approaches for pregnancy interception: Experiences in the rhesus monkey modelDebabrata Ghosh, Jayasree Sengupta · 2005 · Contraception
- Junctional Adhesion Molecule 2 Mediates the Interaction between Hatched Blastocyst and Luminal Epithelium: Induction by Progesterone and LIFRen‐Wei Su, Bo Jia, Hua Ni, Wei Lei, Yue Shun-li, Xuhui Feng, Weng-Bo Deng, Ji‐Long Liu, Zhen‐Ao Zhao, Tong-Song Wang et al. · 2012 · PLoS ONE
- Suppressor of Cytokine Signaling 1 Regulates Embryonic Myelopoiesis Independently of Its Effects on T Cell DevelopmentLynda A. O’Sullivan, Suzita Mohd Noor, Monique C. Trengove, Rowena S. Lewis, Clifford Liongue, Naomi S. Sprigg, Sandra E. Nicholson, Alister C. Ward · 2011 · The Journal of Immunology
- Implantation failure in rats with subclinical hypothyroidism is associated with LIF/STAT3 signalingLing Shan, Yingying Zhou, Shiqiao Peng, Xinyi Wang, Zhongyan Shan, Weiping Teng · 2019 · Endocrine Connections
- Endocrine and paracrine correlates of endometrial receptivity to blastocyst implantation in the human.Debabrata Ghosh, Jayasree Sengupta · 2004 · PubMed
- The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activityPeike Wang, Shuailin Du, Chuanhui Guo, Zhangli Ni, Ziying Huang, Na Deng, Haili Bao, Wenbo Deng, Jinhua Lu, Shuangbo Kong et al. · 2023 · Autophagy
- Exploring the black box of human reproduction: endometrial organoids and assembloids - generation, implantation modeling, and future clinical perspectivesMária Kleinová, Ivan Varga, Michaela Čeháková, Martin Valent, Martin Klein · 2024 · Frontiers in Cell and Developmental Biology
- Relationship between Cytokine Concentration in Serum and Preovulatory Follicular Fluid and in vitro Fertilization/Intracytoplasmic Sperm Injection OutcomeMohamad Eid Hammadeh, C. Fischer‐Hammadeh, Ahmed Samy Soliman Amer, Peter Rosenbaum, Werner Schmidt · 2005 · KARGER eBooks
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- Gastrointestinal Perforations Associated With JAK Inhibitors: A Disproportionality Analysis of the FDA Adverse Event Reporting SystemAdam Goldman, Emanuel Raschi, Amit Druyan, Κassem Sharif, Adi Lahat, Ilan Ben‐Zvi, Shomron Ben‐Horin · 2024 · United European Gastroenterology Journal
- TNF-&agr;-Mediated Stress-Induced Early Pregnancy Loss:A Possible Role of Leukemia Inhibitory FactorArkady M. Torchinsky, Udo Rudolf Markert, Vladimir Toder · 2005 · KARGER eBooks
- Expression of CD73/ecto‐5′‐nucleotidase on human gingival fibroblasts and contribution to the inhibition of interleukin‐1α‐induced granulocyte‐macrophage colony stimulating factor productionEiji Nemoto, Ryotaro Kunii, Hiroyuki Tada, 泰介 鍔原, Hiroshi Ishihata, Hidetoshi Shimauchi · 2003 · Journal of Periodontal Research
- Increased Expression of Suppressor of Cytokine Signaling 1 mRNA in Patients With Rheumatoid ArthritisHua‐Chen Chan, Liang‐Yin Ke, Ching‐Ching Liu, Lin‐Li Chang, Wen‐Chan Tsai, Hong‐Wen Liu, Jeng‐Hsien Yen · 2010 · The Kaohsiung Journal of Medical Sciences
- Immunosuppression with tacrolimus improved implantation and rescued expression of uterine progesterone receptor and its co-regulators FKBP52 and PIASy at nidation in the obese and diabetic mice: Comparative studies with metforminAhmad J. H. Albaghdadi, Frederick W. K. Kan · 2017 · Molecular and Cellular Endocrinology
- Interleukin-6 (IL-6)Tadamitsu Kishimoto · 2003 · Elsevier eBooks
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- Targeting the Glycoprotein 130 Receptor Subunit to Control Pain and InflammationJ. Jazayeri, A. Upadhyay, A. Vernallis, G. Carroll · 2010 · Journal of Interferon and Cytokine Research
- Inflammatory bowel disease: recent advances on genetics and innate immunity.Theodoros Karantanos, Maria Gazouli · 2011 · Europe PMC (PubMed Central)
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- The Structure, Function, and Evaluation of the Female Reproductive TractBruce A. Lessey, Steven L. Young · 2013 · Elsevier eBooks
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- The transcription co-repressor TLE1 interacted with the intracellular region of gp130 through its Q domainFei Liu, Yin Liu, Demin Li, Yong Hong Zhu, Weiming Ouyang, Xin Xie, Boquan Jin · 2002 · Molecular and Cellular Biochemistry
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- ImplantationS DEY, H LIM · 2006 · Elsevier eBooks
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- Implantation and PlacentationSusana M. Chuva de Sousa Lopes, Christine L. Mummery, Sólveig Þorsteinsdóttir · 2005
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- Role of the intracellular receptor domain of gp130 (exon 17) in human inflammatory bowel diseaseC.J. Auernhammer · 2005 · World Journal of Gastroenterology
- Localization of Interleukin-6 Receptor mRNA in the Pregnant and Non-pregnant Mouse UterusEiichi Hondo, Keiji Kokubu, K Kato, Yasuo Kiso · 2005 · Journal of Reproduction and Development
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