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Short-lived and Long-lived Bone Marrow Plasma Cells Are Derived from a Novel Precursor Population
Open accessAbstract
The contribution that long-lived bone marrow (BM) plasma cells (PCs) provide to enduring humoral immunity has been underscored by a number of recent studies. However, little is known about the immediate precursors that give rise to long-lived PCs in the BM of immune individuals. We have identified subsets of antigen-experienced B cells within the immune BM that are precursors to PCs. These PC precursors arise in the BM 14 days after immunization and persist for greater than 9 months. Phenotypically distinct subsets of PC precursors give rise to short-lived or long-lived PCs. The differentiation of PC precursors to PCs occurs in the absence of antigen and requires cell division. The functional significance of these newly identified PC precursors in the persistence and quality of the humoral immune response is discussed.
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Cites
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775
Cited by
Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
Bernasconi, N. L., Traggiai, E., & Lanzavecchia, A. (2002) · Science · doi:10.1126/science.1076071 · Cited by 1,304
Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression
Kallies, A., Hasbold, J., Tarlinton, D. M., Dietrich, W., Corcoran, L. M., Hodgkin, P. D., & Nutt, S. L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040973 · Cited by 531
SAP is required for generating long-term humoral immunity
Crotty, S., Kersh, E. N., Cannons, J., Schwartzberg, P. L., & Ahmed, R. (2003) · Nature · doi:10.1038/nature01318 · Cited by 419
DiLillo, D. J., Hamaguchi, Y., Ueda, Y., Yang, K., Uchida, J., Haas, K. M., Kelsoe, G., & Tedder, T. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.361 · Cited by 385
B Cell Chronic Lymphocytic Leukemia: Lessons Learned from Studies of the B Cell Antigen Receptor
Chiorazzi, N., & Ferrarini, M. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141018 · Cited by 377
Metadata
- Authors
- O'Connor, B. P., Cascalho, M., & Noelle, R. J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-03-18
- Volume
- 195
- Issue
- 6
- Pages
- 737-745
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2119273183
- Cited by
- 159
- References
- 1
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- O'Connor, B. P., Cascalho, M., & Noelle, R. J. (2002). Short-lived and Long-lived Bone Marrow Plasma Cells Are Derived from a Novel Precursor Population. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20011626
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
