The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation
Open accessAbstract
Regulation by transforming growth factor (TGF)-β plays an important role in immune homeostasis. TGF-β inhibits T cell functions by blocking both proliferation and differentiation. Here we show that TGF-β blocks Th1 differentiation by inhibiting the expression of T-bet, the apparent masterregulator of T helper (Th)1 differentiation. Restoration of T-bet expression through retroviral transduction of T-bet into developing Th1 cells abrogated the inhibitory effect of TGF-β. In addition, we show that, contrary to prior suggestions, downregulation of interleukin 12 receptor β2 chain is not key to the TGF-β–mediated effect. Furthermore, we show that the direct inhibitory effect of TGF-β on T cells is responsible, at least in part, for the inability of BALB/c mice to mount a Leishmania-specific Th1 response and to clear Leishmanial infection.
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Cites
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Self-citationREGULATION OF IMMUNE RESPONSES BY TGF-β
Letterio, J. J., & Roberts, A. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.137 · Cited by 1,890
The Regulation of Immunity to Leishmania major
Reiner, S. L. (1995) · Annual Review of Immunology · doi:10.1146/annurev.immunol.13.1.151 · Cited by 1,297
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
Kaplan, M. H., Sun, Y.-L., Hoey, T., & Grusby, M. J. (1996) · Nature · doi:10.1038/382174a0 · Cited by 1,240
Szabo, S. J., Dighe, A. S., Gubler, U., & Murphy, K. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.817 · Cited by 1,005
Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 962
Self-citationRole of T-bet in Commitment of T H 1 Cells Before IL-12-Dependent Selection
Mullen, A. C., High, F. A., Hutchins, A. S., Lee, H. W., Villarino, A. V., Livingston, D. M., Kung, A. L., Cereb, N., Yao, T.-P., Yang, S. Y., et al. (2001) · Science · doi:10.1126/science.1059835 · Cited by 825
Zhang, D.-H., Cohn, L., Ray, P., Bottomly, K., & Ray, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21597 · Cited by 665
Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism
Barral-Netto, M., Barral, A., Brownell, C. E., Skeiky, Y. A. W., Ellingsworth, L. R., Twardzik, D. R., & Reed, S. G. (1992) · Science · doi:10.1126/science.1636092 · Cited by 434
Cited by
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366
Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
Hogg, J. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16900-6 · Cited by 1,294
The immunology of susceptibility and resistance to Leishmania major in mice
Sacks, D., & Noben-Trauth, N. (2002) · Nature Reviews Immunology · doi:10.1038/nri933 · Cited by 1,208
Metadata
- Authors
- Gorelik, L., Constant, S., & Flavell, R. A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-05-28
- Volume
- 195
- Issue
- 11
- Pages
- 1499-1505
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2039992202
- Cited by
- 521
- References
- 24
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
